公开(公告)号：US07848801B2

公开(公告)日：2010-12-07

申请号：US11618558

申请日：2006-12-29

申请人： Darrick Carter ,  Gregory A. Smith

发明人： Darrick Carter ,  Gregory A. Smith

IPC分类号： A61N1/30

CPC分类号： A61N1/30 ,  A61N1/0436 ,  A61N1/0444 ,  A61N1/0448

摘要： A transdermal delivery device to passively deliver active agents to a biological interface includes an active agent reservoir comprising a first active agent of a first polarity; an outer active agent membrane taking the form of an ion-exchange membrane of a second polarity, an interfacial layer having a plurality of freely diffusible monovalent co-ions of the first polarity and having a first side adjacent to the outer active agent membrane and a second side configured to contact a biological interface.

摘要翻译： 将活性剂被动地递送到生物界面的透皮递送装置包括活性剂储存器，其包括第一极性的第一活性剂; 采取第二极性的离子交换膜形式的外部活性剂膜，界面层具有第一极性的多个自由扩散的一价共价离子，并且具有与外部活性剂膜相邻的第一侧和 第二侧构造成接触生物界面。

公开(公告)号：US20100069877A1

公开(公告)日：2010-03-18

申请号：US12556668

申请日：2009-09-10

申请人： Gregory A. Smith ,  Dale Kalamasz ,  Tyler D.J. Westcott ,  Robert P. Kinsey ,  Darrick Carter ,  Paul Sleath

发明人： Gregory A. Smith ,  Dale Kalamasz ,  Tyler D.J. Westcott ,  Robert P. Kinsey ,  Darrick Carter ,  Paul Sleath

IPC分类号： A61M5/00 ,  A61K31/167 ,  A61P23/02

CPC分类号： A61K31/137 ,  A61J3/00 ,  A61K9/08 ,  A61K31/00 ,  A61K31/167 ,  A61K47/38 ,  A61N1/0448 ,  A61K2300/00

摘要： Systems and methods are provided for dispensing compositions comprising sols, sol-forming compounds, or highly viscous compositions into porous substrates. In some embodiments, the porous substrates are elements of transdermal delivery devices. In some embodiments, the highly viscous compositions comprise alkylcellulose ethers, or derivatives thereof, in particular, hydroxypropyl cellulose. Such may be useful in continuous web-based manufacturing processes.

摘要翻译： 提供了用于将包含溶胶，溶胶形成化合物或高粘度组合物的组合物分配到多孔基材中的系统和方法。 在一些实施方案中，多孔底物是透皮递送装置的元件。 在一些实施方案中，高粘度组合物包含烷基纤维素醚或其衍生物，特别是羟丙基纤维素。 这在连续的基于web的制造过程中可能是有用的。

公开(公告)号：US20140037691A1

公开(公告)日：2014-02-06

申请号：US13930953

申请日：2013-06-28

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/0011 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K45/06 ,  A61K2039/55511 ,  A61K2039/55572 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/491

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US20120039994A1

公开(公告)日：2012-02-16

申请号：US13277919

申请日：2011-10-20

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61P37/04 ,  A61K9/127

CPC分类号： A61K39/39 ,  A61K39/0005 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  Y02A50/41 ,  Y02A50/412

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

摘要翻译： 基于在基本上均匀形式提供的合成的吡喃葡萄糖基脂质佐剂（GLA）中发现有用的免疫佐剂性质，公开了组合物和方法，包括用于诱导或增强免疫应答的疫苗和药物组合物。 在化学上，合成的GLA提供了从批次到批次的一致的疫苗组分，而不会损害天然产物佐剂的污染物或活性的波动。 还提供了疫苗和药物组合物，其包括GLA和抗原，Toll样受体（TLR）激动剂，辅助佐剂和载体如药物载体中的一种或多种。

公开(公告)号：US08062783B2

公开(公告)日：2011-11-22

申请号：US11947667

申请日：2007-11-29

申请人： Darrick Carter ,  Joshua K. Hoyt ,  James Thorne ,  Forrest Seitz

发明人： Darrick Carter ,  Joshua K. Hoyt ,  James Thorne ,  Forrest Seitz

IPC分类号： H01M6/00 ,  A61N1/30 ,  H01F7/20

CPC分类号： A61N1/303 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/08 ,  A61N1/306 ,  A61N1/325 ,  H01M2/1038 ,  H01M10/42 ,  H01M10/4257 ,  H01M2200/00 ,  H02J5/005 ,  H02J7/025 ,  H02J50/05 ,  H02J50/10

摘要： Systems, devices, and methods for powering and/or controlling electrically powered devices. A power supply system is operable to provide a voltage across at the active and the counter electrode assemblies of a transdermal delivery device. The system includes a power source and a magnetic coupling element.

摘要翻译： 用于为电力设备供电和/或控制的系统，设备和方法。 电源系统可操作以在透皮递送装置的活性和对电极组件处提供电压。 该系统包括电源和磁耦合元件。

公开(公告)号：US20070213652A1

公开(公告)日：2007-09-13

申请号：US11617609

申请日：2006-12-28

申请人： Darrick Carter

发明人： Darrick Carter

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/37252 ,  G06F19/3418 ,  G06F19/3456 ,  H04L9/32 ,  H04L63/0428 ,  H04L63/10 ,  H04L2209/88

摘要： The present invention comprises an active agent reservoir that stores a quantity of an active agent, an active electrode element operable to apply an electrical potential of a first polarity to deliver at least a portion of the active agent to a biological interface from the iontophoresis device, and a communications port providing a communications path between the iontophoresis device and a remote device. A method of the invention comprises operating an interface system to remotely interact with iontophoresis devices useful in delivery of active agents to biological interfaces including providing a user interface at a location remote from at least some of the iontophoresis devices, communicating with at least two of the iontophoresis devices, and providing information about the iontophoresis devices via the user interface.

摘要翻译： 本发明包括存储一定量的活性剂的活性剂储存器，可操作以施加第一极性的电势以将至少一部分活性剂递送至离子电渗疗法装置的生物界面的活性电极元件， 以及提供离子渗透装置和远程装置之间的通信路径的通信端口。 本发明的方法包括操作界面系统以远程与离子电渗装置相互作用，所述离子电渗装置可用于将活性剂递送到生物界面，包括在远离至少一些离子渗透装置的位置提供用户界面，与至少两个 离子渗透装置，以及通过用户界面提供关于离子电渗装置的信息。

公开(公告)号：US06800746B2

公开(公告)日：2004-10-05

申请号：US09759143

申请日：2001-01-12

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C12Q168

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06512094B1

公开(公告)日：2003-01-28

申请号：US09593793

申请日：2000-06-13

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07K100

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06504010B1

公开(公告)日：2003-01-07

申请号：US09702705

申请日：2000-10-30

申请人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

发明人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US08722064B2

公开(公告)日：2014-05-13

申请号：US12794336

申请日：2010-06-04

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/00 ,  A61K31/70 ,  C07H15/00

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K31/665 ,  A61K31/7016 ,  A61K39/00 ,  A61K39/04 ,  A61K39/21 ,  A61K39/235 ,  A61K39/245 ,  A61K39/275 ,  A61K2039/525 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575 ,  C07H15/04 ,  C07H15/12 ,  C07H15/20

摘要： Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1, Y2, Y3, Y4, R1, R2, R3, R4, R5, R6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.

摘要翻译： 提供具有以下结构（I）的化合物，特别是具有下列结构（I）的吡喃葡萄糖基脂质佐剂（GLA）化合物或其药学上可接受的盐，其中L1，L2，L3，L4，L5，L6，L7，L8，L9，L10， Y1，Y2，Y3，Y4，R1，R2，R3，R4，R5，R6如本文所定义。 还提供了用于诱导或增强免疫应答的药物组合物，疫苗组合物和相关方法。