摘要:
This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要:
There is described a cartridge mounting for locating a cartridge in a printer adjacent a print drum for receiving a charge image from the cartridge. The cartridge includes a spine and has a longitudinal axis substantially parallel to the axis of rotation of the print drum and an inner face adjacent the image receiving portion of the drum surface. The mounting has provision for locating the cartridge radially in relation to the axis of rotation of the drum and for biasing the cartridge towards the drum surface. Further provision is made for locating the cartridge tangentially in opposition to the direction of travel of the drum surface. Spacers extend from the inner face of the cartridge to abut the drum surface at a sliding contact, thus spacing the cartridge a predetermined distance from the surface.
摘要:
The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyses. The invented devices consist of a sensor array formed on an electrode module, the sensor array being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is an element consisting of a plastic card-like body with fluidic conduits and a sealed fluid reservoir contained in a foil-lined cavity.
摘要:
Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.
摘要:
A toner system for delivering powder toner from a storage hopper to an element carrying an electrostatic pattern of charge to be toned before transfer to a receptor such as paper includes a scavenger which, when coupled to the toner system can be actuated to develop a slight negative pressure in the toner system sufficient to entrap flow enhancers such as zinc stearate and to remove the non-magnetic zinc stearate from the toner system. The scavenger includes baffles for collecting particles and means for developing the negative pressure in the toner system.The toner system also includes a pair of magnetic clips for positioning on the metering blade of the toner system to define the width of the toner path being transfered from the toner system to the electrostatic image on the dielectric surface and a cleaning device which periodically moves along the metering blade to clean the front of the metering blade of any accumulated toner.
摘要:
Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.
摘要:
The present invention relates to planar electrochemical sensors with membrane coatings used to perform chemical analyses. The object of this invention is to provide unit-use disposable sensors of very simple and economical construction, preferably with only a single membrane coating on an electrode. The invented devices are potentiometric salt-bridge reference electrodes constructed with a heterogeneous membrane coating of a conductor. The heterogeneous membrane is a formulation that concurrently supports non-volatile species transport through an electrolyte compartment and gas transport through a hydrophobic compartment.
摘要:
The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyses. The invented devices consist of a sensor array formed on an electrode module, the sensor array being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is an element consisting of a plastic card-like body with fluidic conduits and a sealed fluid reservoir contained in a foil-lined cavity.
摘要:
This invention provides an electrostatic printing apparatus comprising a rotatable electrostatically chargeable drum and ion deposition means for forming an electrostatic image on the electrostatically chargeable drum, the improvement comprising means for discharging a flow of air along the path of flow extending between the periphery of the electrostatically chargeable drum and the ion discharge means.