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    Process for preparing glyoxylic acid/dialkyl aminomethylphosphonate mixtures
    2.
    发明授权
    Process for preparing glyoxylic acid/dialkyl aminomethylphosphonate mixtures 失效
    制备乙醛酸/二烷基氨基甲基膦酸酯混合物的方法

    公开(公告)号：US5559020A

    公开(公告)日：1996-09-24

    申请号：US385260

    申请日：1995-02-08

    申请人： David L. Anton ,  Robert Dicosimo

    发明人： David L. Anton ,  Robert Dicosimo

    IPC分类号： C07F9/38 ,  C12N1/19 ,  C12P7/40 ,  C12P13/04 ,  C12R1/78 ,  C12R1/84 ,  C07F9/22 ,  C12P7/42 ,  C12P13/00

    CPC分类号： C12P13/04 ,  C07F9/3813 ,  C12P7/40

    摘要： The invention provides a process for producing mixtures of glyoxylate and a dialkyl aminomethylphosphonate and the subsequent production of N-(phosphonomethyl)glycine, also known as glyphosate. The process comprises preparing in situ a mixture of glyoxylate and a dialkyl aminomethylphosphonate (DEAMPA) by enzymatically reacting glycolic acid (glycolate) and oxygen in an aqueous solution in the presence of a dialkyl aminomethylphosphonate and catalysts consisting of glycolate oxidase and catalase. The resulting mixture can be hydrogenated and then subjected to hydrolysis to produce N-(phosphonomethyl)glycine, a post-emergent phytotoxicant and herbicide.

    摘要翻译： 本发明提供了一种生产乙醛酸盐和氨基甲基膦酸二烷基酯混合物的方法，随后生产N-（膦酰基甲基）甘氨酸，也称为草甘膦。 该方法包括在二烷基氨基甲基膦酸二烷基酯和由乙醇酸氧化酶和过氧化氢酶组成的催化剂的存在下，使乙醇酸（乙醇酸）和氧在水溶液中酶促反应，原位制备乙醛酸和二烷基氨基甲基膦酸二乙酯（DEAMPA）的混合物。 所得混合物可以氢化，然后进行水解以产生N-（膦酰基甲基）甘氨酸，芽后植物毒素和除草剂。

    Perhydrolase providing improved specific activity
    4.
    发明授权
    Perhydrolase providing improved specific activity 失效
    过水解酶提供更好的比活性

    公开(公告)号：US08389255B2

    公开(公告)日：2013-03-05

    申请号：US13070135

    申请日：2011-03-23

    申请人： Robert Dicosimo ,  John Edward Gavagan ,  Mark Scott Payne

    发明人： Robert Dicosimo ,  John Edward Gavagan ,  Mark Scott Payne

    IPC分类号： C12N9/18

    CPC分类号： C12N9/18 ,  C11D3/38636 ,  C12P7/40 ,  C12P7/54

    摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

    摘要翻译： 提供具有过水解活性的乙酰木聚糖酯酶变体，用于从羧酸酯和过氧源产生过氧羧酸。 更具体地，使用易错PCR和定点诱变来修饰热转录海马乙酰木聚糖酯酶基因，以产生特征在于比活性增加的酶催化剂。 变体乙酰木聚糖酯酶可用于制备适用于各种用途的过氧羧酸，例如清洁，消毒，消毒，漂白，木浆加工和纸浆加工应用。

    PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    6.
    发明申请
    PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY 失效
    PERHYDROLASE变体提供改进的特定活性

    公开(公告)号：US20120156162A1

    公开(公告)日：2012-06-21

    申请号：US13328418

    申请日：2011-12-16

    申请人： Robert Dicosimo ,  Mark Scott Payne ,  John Edward Gavagan

    发明人： Robert Dicosimo ,  Mark Scott Payne ,  John Edward Gavagan

    IPC分类号： A61L9/01 ,  C12N9/16 ,  C12N1/21 ,  D21H21/32 ,  A01N37/02 ,  C07H21/04 ,  D06L3/00 ,  C12P7/62 ,  C12N15/63

    CPC分类号： C12N9/18 ,  C12Y301/01072

    摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritime acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

    摘要翻译： 提供具有过水解活性的乙酰木聚糖酯酶变体，用于从羧酸酯和过氧源产生过氧羧酸。 更具体地，使用易错PCR和定点诱变来修饰Thermotoga海洋乙酰木聚糖酯酶基因，以产生特征在于比活性增加的酶催化剂。 变体乙酰木聚糖酯酶可用于制备适用于各种用途的过氧羧酸，例如清洁，消毒，消毒，漂白，木浆加工和纸浆加工应用。

    Immobilized microbial nitrilase for production of glycolic acid
    10.
    发明授权
    Immobilized microbial nitrilase for production of glycolic acid 有权
    用于生产乙醇酸的固定化微生物腈水解酶

    公开(公告)号：US07695945B2

    公开(公告)日：2010-04-13

    申请号：US11930550

    申请日：2007-10-31

    申请人： Robert Dicosimo ,  Arie Ben-Bassat

    发明人： Robert Dicosimo ,  Arie Ben-Bassat

    IPC分类号： C12N9/96 ,  C12P21/06 ,  C12N9/00 ,  C12N9/78 ,  C07H21/04

    CPC分类号： C12N9/78 ,  C12N11/06 ,  C12N11/10 ,  C12P7/42 ,  Y02P20/584 ,  Y02P20/588

    摘要： The present invention provides a process for preparing an enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid with improved retention of recovered catalyst activity in consecutive batch reactions with catalyst recycle, said process comprising pretreating the enzyme catalyst with glutaraldehyde. The glutaraldehyde-pretreated enzyme catalyst has improved specific activity when compared to non-glutaraldehyde-pretreated enzyme catalysts, and thereby, has improved overall catalyst activity and productivity.

    摘要翻译： 本发明提供一种制备具有腈水解酶活性的酶催化剂的方法，所述酶催化剂具有乙醇腈水解为乙醇酸的酶催化剂，其具有在催化剂再循环的连续间歇反应中具有回收的催化剂活性的保持性，所述方法包括用戊二醛预处理酶催化剂。 与非戊二醛预处理的酶催化剂相比，戊二醛预处理的酶催化剂具有改善的比活性，从而改善了总的催化剂活性和生产率。