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    Systems, methods, and apparatus for securing user documents
    1.
    发明授权
    Systems, methods, and apparatus for securing user documents 有权

    公开(公告)号：US09336382B2

    公开(公告)日：2016-05-10

    申请号：US13156045

    申请日：2011-06-08

    Applicant: Brian John Cepuran ,  Daryl McMillan ,  David Lockhart ,  Dariusz Grabka

    Inventor： Brian John Cepuran ,  Daryl McMillan ,  David Lockhart ,  Dariusz Grabka

    IPC: H04L29/06 ,  G06F21/51

    Abstract: The invention is directed to systems, methods and apparatus for securing documents. The system comprises a server having a processor and a data storage device for storing documents, at least one document provider connected to the server, the at least one document provider operable to provide user documents to the server for storage in the data storage device, the user documents containing at least one object of security concern, and at least one document consumer connected to the server, the at least one document consumer operable to receive the user documents containing the at least one object of security concern from the server. The processor in the server is operable to determine whether to provide the at least one object of security concern to the at least one document consumer based on at least one security setting, and based on the decision either provide the documents with the at least one object of security concern or provide a replacement documents without the security of concern and an indication on each replacement document that that the at least one object of security concern has been excluded.

    Uncoupling of DNA insert propagation and expression of protein for phage display
    4.
    发明申请
    Uncoupling of DNA insert propagation and expression of protein for phage display 有权
    DNA插入片段的解偶联和蛋白质的表达用于噬菌体展示

    公开(公告)号：US20070105093A1

    公开(公告)日：2007-05-10

    申请号：US11534527

    申请日：2006-09-22

    Applicant: Pietro Ciceri ,  Patrick Zarrinkar ,  Daniel Treiber ,  David Lockhart

    Inventor： Pietro Ciceri ,  Patrick Zarrinkar ,  Daniel Treiber ,  David Lockhart

    IPC: C40B30/06 ,  C40B50/06 ,  C40B40/08 ,  C40B40/10

    CPC classification number: C07H21/04 ,  C12N15/1037 ,  C40B40/02

    Abstract: The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage constructs and methods for their use to permit phage coat protein expression, and thus phage propagation, in the absence of display of heterologous polypeptides, which may be expressed as a fusion with said coat protein in a regulated manner.

    Abstract translation: 本发明通过允许从所述多肽的表达中分离含有编码异源多肽的插入序列的噬菌体的繁殖来提供噬菌体展示技术的进步。 本发明提供了噬菌体构建体和方法，用于在不显示异源多肽的情况下允许噬菌体外壳蛋白表达，从而允许噬菌体扩增，从而可以以调节的方式表达为与所述外壳蛋白的融合。

    Expression monitoring to high density oligonucleotide arrays
    10.
    发明申请
    Expression monitoring to high density oligonucleotide arrays 审中-公开
    对高密度寡核苷酸阵列的表达监测

    公开(公告)号：US20050202500A1

    公开(公告)日：2005-09-15

    申请号：US11118974

    申请日：2005-04-28

    Applicant: David Lockhart ,  Eugene Brown ,  Gordon Wong ,  Mark Chee ,  Thomas Gingeras

    Inventor： David Lockhart ,  Eugene Brown ,  Gordon Wong ,  Mark Chee ,  Thomas Gingeras

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N15/14 ,  G01N37/00 ,  C12P19/34 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

    CPC classification number: C12Q1/6809 ,  C12Q1/6837 ,  G01N15/1475 ,  C12Q2565/507

    Abstract: This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.

    Abstract translation: 本发明提供监测多种基因的表达水平的方法。 所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。 在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中 包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸 探针与衍生自RNA转录物的RNA转录物或核酸互补; 并量化阵列中的杂交核酸。

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