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    System and method for facilitating the pre-publication peer review process
    4.
    发明授权
    System and method for facilitating the pre-publication peer review process 失效

    公开(公告)号：US07007232B1

    公开(公告)日：2006-02-28

    申请号：US09545316

    申请日：2000-04-07

    申请人： Brian Dale Ross ,  Lauren Daniel Stegman ,  Alnawaz Rehemtulla

    发明人： Brian Dale Ross ,  Lauren Daniel Stegman ,  Alnawaz Rehemtulla

    IPC分类号： G06F15/00

    CPC分类号： G06F17/243 ,  G06F17/30861 ,  G06Q10/00

    摘要： An improved method for facilitating the peer review process in scholarly publications is presented. This improved method streamlines and compresses the review process, eliminating unnecessary delays and costs inherent in the traditional process. The present invention implements a computer based manuscript tracking process the uses the World Wide Web to allow ubiquitous access to the manuscript under review. This ubiquitous access works in conjunction with automatic generation of potential reviewers and instant notification to authors, editors, and reviewers of significant milestones in the peer review process. Authors are allowed to communicate with anonymous reviewers to reduce the number of revisions leading to approval. Additionally, multiple authors are allowed to collaborate during the manuscript creation process as well as the manuscript review process. This allows several geographically disperse authors to conveniently co-author a manuscript. It additionally allows the author or several authors to respond to comments from the reviewer prior to an editor reading the review.

    Imaging system, computer, program product and method for detecting changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI)
    5.
    发明授权
    Imaging system, computer, program product and method for detecting changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI) 有权
    使用磁共振成像（MRI）检测组织中水扩散速率变化的成像系统，计算机，程序产品和方法

    公开(公告)号：US06567684B1

    公开(公告)日：2003-05-20

    申请号：US09732362

    申请日：2000-12-06

    申请人： Thomas L. Chenevert ,  Alnawaz Rehemtulla ,  Brian D. Ross

    发明人： Thomas L. Chenevert ,  Alnawaz Rehemtulla ,  Brian D. Ross

    IPC分类号： A61B5055

    CPC分类号： A61B5/055 ,  A61B5/4076 ,  G06F19/00

    摘要： The invention provides a computer-implemented method for detecting changes in rates of water diffusion in a tissue. The invention also provides a computer program product for use in the detection of changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI) comprising a computer useable medium comprising a computer readable program code embodied therein, wherein the computer program product is capable of storing and analyzing data input from a MRI device. The invention also provides a computer system, comprising a processor and a computer program product of the invention. The invention also provides a tissue imaging system, comprising a magnetic resonance imaging (MRI) device capable of outputting data to a processor; a processor; and, a computer program product of the invention embodied within the processor.

    摘要翻译： 本发明提供了一种用于检测组织中水扩散速率变化的计算机实现的方法。 本发明还提供了一种计算机程序产品，用于使用包括计算机可用介质的磁共振成像（MRI）来检测组织中水扩散速率的变化，所述计算机可用介质包括其中包含的计算机可读程序代码，其中所述计算机程序产品是 能够存储和分析从MRI设备输入的数据。 本发明还提供一种包括本发明的处理器和计算机程序产品的计算机系统。 本发明还提供一种组织成像系统，包括能够向处理器输出数据的磁共振成像（MRI）装置; 处理器 以及体现在处理器内的本发明的计算机程序产品。

    Compositions and methods for detecting proteolytic activity
    7.
    发明授权
    Compositions and methods for detecting proteolytic activity 失效
    用于检测蛋白水解活性的组合物和方法

    公开(公告)号：US07378078B2

    公开(公告)日：2008-05-27

    申请号：US10452184

    申请日：2003-06-02

    申请人： Brian D. Ross ,  Alnawaz Rehemtulla

    发明人： Brian D. Ross ,  Alnawaz Rehemtulla

    IPC分类号： A61K49/00 ,  A61K38/48 ,  A61B5/00 ,  A01N63/00 ,  C12P21/04 ,  C12N15/00 ,  C12N5/00

    CPC分类号： C12Q1/37 ,  A01K2217/05 ,  G01N2333/96466 ,  G01N2500/10

    摘要： The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The invention provides a chimeric polypeptide having a bioluminescent or chemiluminescent polypeptide, or a heterologous kinase, and at least one silencing moiety, and a protease cleavage motif positioned between the first and second domains. The imaging can be by computer assisted tomography (CAT), magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), or bioluminescence imaging (BLI).

    摘要翻译： 本发明提供了用于体外，体内和原位的细胞，组织和器官以及整个体中酶的非侵入性成像（例如蛋白酶）活性的组合物和方法。 本发明提供了具有生物发光或化学发光多肽或异源激酶，以及至少一个沉默部分和位于第一和第二结构域之间的蛋白酶切割基序的嵌合多肽。 成像可以通过计算机辅助断层扫描（CAT），磁共振光谱（MRS），磁共振成像（MRI），正电子发射断层扫描（PET），单光子发射计算机断层扫描（SPECT）或生物发光成像（BLI）进行。

    System and method for facilitating the pre-publication peer review process
    8.
    发明授权
    System and method for facilitating the pre-publication peer review process 失效
    促进出版前同行评审过程的系统和方法

    公开(公告)号：US07539938B2

    公开(公告)日：2009-05-26

    申请号：US11336489

    申请日：2006-01-20

    申请人： Brian Dale Ross ,  Lauren Daniel Stegman ,  Alnawaz Rehemtulla

    发明人： Brian Dale Ross ,  Lauren Daniel Stegman ,  Alnawaz Rehemtulla

    IPC分类号： G06F17/00

    CPC分类号： G06F17/243 ,  G06F17/30861 ,  G06Q10/00

    摘要： An improved method for facilitating the peer review process in scholarly publications is presented. This improved method streamlines and compresses the review process, eliminating unnecessary delays and costs inherent in the traditional process. The present invention implements a computer based manuscript tracking process the uses the World Wide Web to allow ubiquitous access to the manuscript under review. This ubiquitous access works in conjunction with automatic generation of potential reviewers and instant notification to authors, editors, and reviewers of significant milestones in the peer review process. Authors are allowed to communicate with anonymous reviewers to reduce the number of revisions leading to approval. Additionally, multiple authors are allowed to collaborate during the manuscript creation process as well as the manuscript review process. This allows several geographically disperse authors to conveniently co-author a manuscript. It additionally allows the author or several authors to respond to comments from the reviewer prior to an editor reading the review.

    摘要翻译： 介绍了在学术刊物中促进同行评议过程的改进方法。 这种改进的方法简化和压缩了审查过程，消除了传统过程固有的不必要的延迟和成本。 本发明实现了一种基于计算机的手稿跟踪过程，其使用万维网允许无处不在地访问正在审查的手稿。 这种无所不在的访问与自动生成潜在评论者并在作者，编辑和审阅者中进行同步评估过程中重要里程碑的工作。 允许作者与匿名审核人员进行沟通，以减少导致批准的修订数量。 此外，允许多位作者在稿件制作过程中以及手稿审核过程中进行合作。 这使得几个地理分散的作者能够方便地共同撰写稿件。 它还允许作者或几位作者在编辑阅读评论之前回复评论者的评论。