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16 条记录 (耗时 0.028 秒)

    Imaging system, computer, program product and method for detecting changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI)
    3.
    发明授权
    Imaging system, computer, program product and method for detecting changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI) 有权
    使用磁共振成像（MRI）检测组织中水扩散速率变化的成像系统，计算机，程序产品和方法

    公开(公告)号：US06567684B1

    公开(公告)日：2003-05-20

    申请号：US09732362

    申请日：2000-12-06

    申请人： Thomas L. Chenevert ,  Alnawaz Rehemtulla ,  Brian D. Ross

    发明人： Thomas L. Chenevert ,  Alnawaz Rehemtulla ,  Brian D. Ross

    IPC分类号： A61B5055

    CPC分类号： A61B5/055 ,  A61B5/4076 ,  G06F19/00

    摘要： The invention provides a computer-implemented method for detecting changes in rates of water diffusion in a tissue. The invention also provides a computer program product for use in the detection of changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI) comprising a computer useable medium comprising a computer readable program code embodied therein, wherein the computer program product is capable of storing and analyzing data input from a MRI device. The invention also provides a computer system, comprising a processor and a computer program product of the invention. The invention also provides a tissue imaging system, comprising a magnetic resonance imaging (MRI) device capable of outputting data to a processor; a processor; and, a computer program product of the invention embodied within the processor.

    摘要翻译： 本发明提供了一种用于检测组织中水扩散速率变化的计算机实现的方法。 本发明还提供了一种计算机程序产品，用于使用包括计算机可用介质的磁共振成像（MRI）来检测组织中水扩散速率的变化，所述计算机可用介质包括其中包含的计算机可读程序代码，其中所述计算机程序产品是 能够存储和分析从MRI设备输入的数据。 本发明还提供一种包括本发明的处理器和计算机程序产品的计算机系统。 本发明还提供一种组织成像系统，包括能够向处理器输出数据的磁共振成像（MRI）装置; 处理器 以及体现在处理器内的本发明的计算机程序产品。

    Compositions and methods for detecting proteolytic activity
    6.
    发明授权
    Compositions and methods for detecting proteolytic activity 失效
    用于检测蛋白水解活性的组合物和方法

    公开(公告)号：US07378078B2

    公开(公告)日：2008-05-27

    申请号：US10452184

    申请日：2003-06-02

    申请人： Brian D. Ross ,  Alnawaz Rehemtulla

    发明人： Brian D. Ross ,  Alnawaz Rehemtulla

    IPC分类号： A61K49/00 ,  A61K38/48 ,  A61B5/00 ,  A01N63/00 ,  C12P21/04 ,  C12N15/00 ,  C12N5/00

    CPC分类号： C12Q1/37 ,  A01K2217/05 ,  G01N2333/96466 ,  G01N2500/10

    摘要： The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The invention provides a chimeric polypeptide having a bioluminescent or chemiluminescent polypeptide, or a heterologous kinase, and at least one silencing moiety, and a protease cleavage motif positioned between the first and second domains. The imaging can be by computer assisted tomography (CAT), magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), or bioluminescence imaging (BLI).

    摘要翻译： 本发明提供了用于体外，体内和原位的细胞，组织和器官以及整个体中酶的非侵入性成像（例如蛋白酶）活性的组合物和方法。 本发明提供了具有生物发光或化学发光多肽或异源激酶，以及至少一个沉默部分和位于第一和第二结构域之间的蛋白酶切割基序的嵌合多肽。 成像可以通过计算机辅助断层扫描（CAT），磁共振光谱（MRS），磁共振成像（MRI），正电子发射断层扫描（PET），单光子发射计算机断层扫描（SPECT）或生物发光成像（BLI）进行。

    Tissue phasic classification mapping system and method
    9.
    发明授权
    Tissue phasic classification mapping system and method 有权

    公开(公告)号：US09773311B2

    公开(公告)日：2017-09-26

    申请号：US13539254

    申请日：2012-06-29

    申请人： Brian D. Ross ,  Craig Galban

    发明人： Brian D. Ross ,  Craig Galban

    IPC分类号： G06K9/00 ,  G06T7/00 ,  G06T7/136

    CPC分类号： G06T7/0016 ,  G06T7/136 ,  G06T2207/10081 ,  G06T2207/30061

    摘要： A voxel-based technique is provided for performing quantitative imaging and analysis of tissue image data. Serial image data is collected for tissue of interest at different states of the issue. The collected image data may be deformably registered, after which the registered image data is analyzed on a voxel-by-voxel basis, thereby retaining spatial information for the analysis. Various thresholds are applied to the registered tissue data to identify a tissue condition or state, such as classifying chronic obstructive pulmonary disease by disease phenotype in lung tissue, for example.

    IMAGING AGENTS AND METHODS OF USE THEREOF
    10.
    发明申请
    IMAGING AGENTS AND METHODS OF USE THEREOF 审中-公开
    成像剂及其使用方法

    公开(公告)号：US20090264732A1

    公开(公告)日：2009-10-22

    申请号：US12090062

    申请日：2006-10-11

    申请人： Brian D. Ross ,  Pratip Bhattacharya

    发明人： Brian D. Ross ,  Pratip Bhattacharya

    IPC分类号： A61B5/055

    CPC分类号： G01R33/282 ,  A61K49/10 ,  G01R33/5601

    摘要： The present invention relates to compositions and methods useful in connection with magnetic resonance imaging. In various embodiments, the invention employs the PASADENA polarization technique to prepare contrast agents that target complementary molecules in the body and/or that are processed through predetermined, natural metabolic pathways. The invention includes methods of using the contrast agents and kits including the same. In one embodiment, a diagnostic and prognostic method relating to Alzheimer's disease is described. Further embodiments relate to medical devices including the contrast agents.

    摘要翻译： 本发明涉及可用于磁共振成像的组合物和方法。 在各种实施方案中，本发明使用PASADENA偏振技术来制备靶向体内互补分子和/或通过预定的天然代谢途径加工的造影剂。 本发明包括使用造影剂的方法和包括它们的试剂盒。 在一个实施方案中，描述了与阿尔茨海默病有关的诊断和预后方法。 其它实施方案涉及包括造影剂的医疗装置。