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    Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside
    3.
    发明授权
    Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside 失效
    可生物降解的微胶囊，其具有由交联的胶原和聚氧化物组成的壁

    公开(公告)号：US5395620A

    公开(公告)日：1995-03-07

    申请号：US74701

    申请日：1993-06-08

    申请人： Alain Huc ,  Marie-Christine Levy ,  Chantal Buffevant ,  Marie-Christine Andry

    发明人： Alain Huc ,  Marie-Christine Levy ,  Chantal Buffevant ,  Marie-Christine Andry

    IPC分类号： A61K8/11 ,  A61K8/65 ,  A61K8/67 ,  A61K8/73 ,  A61K9/16 ,  A61K9/50 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/04 ,  B01J13/10

    CPC分类号： A61K8/11 ,  A61K8/65 ,  A61K8/676 ,  A61K8/735 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/5036 ,  A61K9/5052 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/04 ,  B01J13/10 ,  A61K2800/412 ,  Y10S514/963 ,  Y10T428/2989

    摘要： The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath. These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. They are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.

    摘要翻译： 本发明涉及具有交联的阿胶原和多聚半乳糖苷的混合壁（例如葡糖胺聚糖）的微胶囊以及用于制备所述微胶囊的方法。 根据本发明，微胶囊包含交联的胶原蛋白和多聚半乳糖苷的混合壁，例如糖胺聚糖，多羟基化合物例如糖胺聚糖相对于胶原凝胶的比例优选在18-50重量％之间。 这些微胶囊可以通过涉及界面交联的过程或通过振动分解成分散到交联浴中的各个液滴的层流的挤出来制造。 这些微胶囊由于存在胶原蛋白而具有生物相容性，其具有胶原蛋白的大部分有利性质，即非常低的抗原性和完美的生物降解性。 因此，它们特别适用于制造化妆品，药​​物或食品组合物。

    Particles prepared by transacylation reaction between an esterified polysaccharide and a polyamine, methods of preparation therefor and compositions containing same
    8.
    发明授权
    Particles prepared by transacylation reaction between an esterified polysaccharide and a polyamine, methods of preparation therefor and compositions containing same 失效
    通过酯化多糖和多胺之间的转酰胺反应制备的颗粒，其制备方法和含有它们的组合物

    公开(公告)号：US5635609A

    公开(公告)日：1997-06-03

    申请号：US492057

    申请日：1995-07-20

    申请人： Marie-Christine Levy ,  Florence Edwards-Levy ,  Isabelle Orly

    发明人： Marie-Christine Levy ,  Florence Edwards-Levy ,  Isabelle Orly

    IPC分类号： A61K9/14 ,  A61K9/50 ,  A61K47/36 ,  B01J13/14 ,  C12N11/04

    CPC分类号： B01J13/14 ,  C12N11/04

    摘要： Particles, preparation methods therefor, and compositions containing same. The particles include at least one esterified polysaccharide and at least one polyamine, as well as at least one gellable polysaccharide when neither the esterified polysaccharide nor the polyamine can be gelled under the selected operating conditions. Said particle includes, at least on its surface, a membrane consisting of the product of the transacylation reaction between the esterified polysaccharide and said polyamine within an optionally gellable gel, said reaction causing the formation of covalent amide bonds. Such particles may be used to encapsulated various active principles useful in the fields of cosmetics, pharmaceuticals and agri-foodstuffs, enzymes, cells and micro-organisms.

    摘要翻译： PCT No.PCT / FR94 / 00409 Sec。 371日期1995年7月20日 102（e）日期1995年7月20日PCT 1994年4月13日提交PCT公布。 第WO94 / 23832号公报 日期1994年10月27日粒子，其制备方法和含有它们的组合物。 所述颗粒包括至少一种酯化多糖和至少一种多胺，以及至少一种可凝胶多糖，当所选择的操作条件下酯化的多糖和聚胺都不能凝胶化时。 所述颗粒至少在其表面上包括由任选可凝胶化凝胶内的酯化多糖和所述多胺之间的转酰基反应的产物组成的膜，所述反应引起共价酰胺键的形成。 这种颗粒可用于包封可用于化妆品，药​​物和农产品，酶，细胞和微生物领域的各种活性成分。