公开(公告)号：US08119638B2

公开(公告)日：2012-02-21

申请号：US11769873

申请日：2007-06-28

申请人： Esteban Cvitkovich ,  George Daniel Demetri ,  Cecilia Guzman ,  Jose Jimeno ,  Luis Lopez Lazaro ,  Jean Louis Misset ,  Chris Twelves ,  Daniel D. Von Hoff

发明人： Esteban Cvitkovich ,  George Daniel Demetri ,  Cecilia Guzman ,  Jose Jimeno ,  Luis Lopez Lazaro ,  Jean Louis Misset ,  Chris Twelves ,  Daniel D. Von Hoff

IPC分类号： A61K31/495 ,  A61K31/56

CPC分类号： A61K31/4995

摘要： Et 743 is used in the preparation of a medicament for the treatment of the human body for cancer.

摘要翻译： Et 743用于制备用于治疗人体癌症的药物。

公开(公告)号：US20090099165A1

公开(公告)日：2009-04-16

申请号：US11735344

申请日：2007-04-13

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/519

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

公开(公告)号：US4772261A

公开(公告)日：1988-09-20

申请号：US8874

申请日：1987-01-29

申请人： Daniel D. Von Hoff ,  John G. Kuhn ,  Paul W. Leighton ,  Howard M. Wakeman

发明人： Daniel D. Von Hoff ,  John G. Kuhn ,  Paul W. Leighton ,  Howard M. Wakeman

IPC分类号： A61B17/68 ,  A61B17/86 ,  A61M37/00 ,  A61M25/00

CPC分类号： A61B17/864 ,  A61B17/68 ,  A61M37/00

摘要： An intramedullary catheter is provided which is attached to a bone to permit the infusion of drugs, fluids, or the like, directly into the bone marrow for subsequent dispersion to the vascular system. The present invention contemplates an intramedullary catheter, method of implanting such a catheter, and a method of fluid delivery to the vascular system through the bone marrow. The intramedullary catheter preferably includes a threaded conduit, a head attached to one end of the conduit, and a sealing membrane in the head overlying the conduit. The intramedullary catheter is implanted in a bone, such as the iliac crest, with the conduit threadingly engaging the bone and the surrounding skin closed over the head and membrane. Fluids are delivered by inserting a needle through the membrane into communication with the conduit for transport to the bone marrow. The present invention is particularly appropriate for patients who require long-term administration of medications as an alternative to intravenous delivery.

摘要翻译： 提供了一种髓内导管，其连接到骨以允许将药物，流体等直接注入骨髓中，以便随后分散到血管系统。 本发明考虑到髓内导管，植入这种导管的方法，以及通过骨髓向血管系统输送液体的方法。 髓内导管优选地包括螺纹导管，附接到导管的一端的头部和头部中覆盖导管的密封膜。 髓内导管植入骨骼，如髂嵴，导管螺纹接合骨骼，周围皮肤封闭在头部和膜上。 通过将针穿过膜与导管连通以输送到骨髓来输送流体。 本发明特别适用于需要长期施用药物作为静脉内递送替代物的患者。

公开(公告)号：US08394742B2

公开(公告)日：2013-03-12

申请号：US11910591

申请日：2006-04-14

申请人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

发明人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

IPC分类号： C40B30/06 ,  C12N15/11

CPC分类号： C07C235/84 ,  C07D231/54 ,  C07D233/64 ,  C07D263/32 ,  C07D277/48 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011

摘要： This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.

摘要翻译： 本发明涉及用于筛选和鉴定能够以特定功能丧失功能改变选择性地除去癌细胞的化合物的方法，包括但不限于突变，缺失，高甲基化和其他类型的基因沉默。 本发明还涉及以特定的功能丧失改变选择性地消除癌细胞的新型化合物。 此外，本发明涉及用于特异性功能丧失改变选择性地消除癌细胞的化合物的生产和治疗用途的方法。

公开(公告)号：US20110212929A1

公开(公告)日：2011-09-01

申请号：US13051790

申请日：2011-03-18

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/635 ,  C07D487/04 ,  A61K31/496 ,  C07D471/14 ,  A61K31/519 ,  C07D413/14 ,  A61K31/5377 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20090137420A1

公开(公告)日：2009-05-28

申请号：US11910591

申请日：2006-04-14

申请人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

发明人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

IPC分类号： C40B30/06 ,  C07C233/77 ,  C07D263/32 ,  C07D231/54 ,  C07D277/46

CPC分类号： C07C235/84 ,  C07D231/54 ,  C07D233/64 ,  C07D263/32 ,  C07D277/48 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011

摘要： This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.

摘要翻译： 本发明涉及用于筛选和鉴定能够以特定功能丧失功能改变选择性地除去癌细胞的化合物的方法，包括但不限于突变，缺失，高甲基化和其他类型的基因沉默。 本发明还涉及以特定的功能丧失改变选择性地消除癌细胞的新型化合物。 此外，本发明涉及用于特异性功能丧失改变选择性地消除癌细胞的化合物的生产和治疗用途的方法。

公开(公告)号：US06562870B1

公开(公告)日：2003-05-13

申请号：US08527880

申请日：1995-09-14

申请人： Daniel D. Von Hoff ,  Alan A. Rubin

发明人： Daniel D. Von Hoff ,  Alan A. Rubin

IPC分类号： A61K31135

CPC分类号： A61K33/24

摘要： The present invention comprises an improved method of treatment of AIDS-associated non-Hodgkin's lymphoma by administering gallium nitrate in a pharmaceutically acceptable vehicle.

摘要翻译： 本发明包括通过在药学上可接受的载体中施用硝酸镓来治疗AIDS相关性非霍奇金淋巴瘤的改进方法。

公开(公告)号：US20120015843A1

公开(公告)日：2012-01-19

申请号：US13188350

申请日：2011-07-21

申请人： Daniel D. Von Hoff ,  Robert Penny

发明人： Daniel D. Von Hoff ,  Robert Penny

IPC分类号： C40B30/04 ,  C12Q1/68 ,  C40B30/00 ,  G01N33/566

CPC分类号： G01N33/57492 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57484 ,  G01N2800/52 ,  G16B50/00 ,  G16H15/00 ,  G16H50/20

摘要： Provided herein are methods and systems for identifying a therapeutic for an individual, such as a therapeutic not previously identified for treating the individual. The therapeutic can be identified by molecular profiling, such as determining the biomarker patterns or signature sets of a biological sample of an individual.

摘要翻译： 本文提供用于鉴定个体的治疗剂的方法和系统，例如先前未鉴定用于治疗个体的治疗剂。 可以通过分子谱分析来鉴定治疗剂，例如确定个体生物样品的生物标志物模式或特征集。

公开(公告)号：US06319923B1

公开(公告)日：2001-11-20

申请号：US09505043

申请日：2000-02-16

申请人： Daniel L. Dexter ,  Paul E. Juniewicz ,  James B. Rake ,  Daniel D. Von Hoff

发明人： Daniel L. Dexter ,  Paul E. Juniewicz ,  James B. Rake ,  Daniel D. Von Hoff

IPC分类号： A61K3153

CPC分类号： A61K31/555 ,  A61K33/24 ,  A61K31/335 ,  A61K31/53 ,  A61K2300/00

摘要： In accordance with the present invention there is provided a method of treating a mammal having a solid tumor, the method comprising: a) administering to the mammal an effective amount of 3-ainino-1,2,4-benzotriazine 1,4-dioxide; b) administering to the mammal an effective amount of paclitaxel; and c) administering to the mammal an effective amount of a platinum complex. The method provides unexpected synergistic efficacy. The invention further provides a kit for treatment of a mammalian tumor comprising 3-amino-1,2,-benzotriazine 1,4-dioxide, paclitaxel and a platinum complex.

摘要翻译： 根据本发明，提供了一种治疗具有实体瘤的哺乳动物的方法，所述方法包括：a）向哺乳动物施用有效量的3-氨基-1,2,4-苯并三嗪1,4-二氧化物 b）向哺乳动物施用有效量的紫杉醇; 和c）向哺乳动物施用有效量的铂络合物。 该方法提供了意想不到的协同疗效。 本发明还提供了用于治疗哺乳动物肿瘤的试剂盒，其包含3-氨基-1,2-苯并三嗪1,4-二氧化物，紫杉醇和铂络合物。

公开(公告)号：US20170199209A1

公开(公告)日：2017-07-13

申请号：US15398226

申请日：2017-01-04

申请人： Daniel D. Von Hoff ,  David M. Loesch ,  Arlet Alarcon ,  Robert J. Penny ,  Alan Wright ,  Matthew J. McGinniss ,  Ryan P. Bender ,  Traci Pawlowski

发明人： Daniel D. Von Hoff ,  David M. Loesch ,  Arlet Alarcon ,  Robert J. Penny ,  Alan Wright ,  Matthew J. McGinniss ,  Ryan P. Bender ,  Traci Pawlowski

IPC分类号： G01N35/00 ,  G06F19/00 ,  G01N33/543 ,  B01L7/00 ,  G06F19/20 ,  C12Q1/68

CPC分类号： G01N35/00029 ,  B01L7/52 ,  C12Q1/6841 ,  C12Q1/6874 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C40B60/12 ,  G01N33/54366 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N35/00871 ,  G01N2035/00138 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00346 ,  G01N2035/00366 ,  G01N2035/00881 ,  G01N2035/0091 ,  G01N2333/47 ,  G01N2333/9029 ,  G01N2333/91205 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/52 ,  G06F19/34 ,  G06F19/3418 ,  G06F19/3456 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B35/00 ,  G16B40/00 ,  G16B45/00 ,  G16B50/00 ,  G16B99/00 ,  G16C20/60 ,  G16H10/20 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20 ,  Y02A90/26

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.