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1.发明授权公开(公告)号：US08569036B2
公开(公告)日：2013-10-29
申请号：US11485575
申请日：2006-07-12
申请人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Tina K. Van Dyk , Robert J. Trotman
发明人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Tina K. Van Dyk , Robert J. Trotman
摘要： TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
摘要翻译： 使用低浓度戊二醛将TAL细胞生物催化剂固定在藻酸盐交联珠粒中。 生物催化剂珠具有高度稳定的TAL活性和机械强度，使得它们在pHCA的生产中经受长时间的再循环。
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2.发明申请公开(公告)号：US20080032371A1
公开(公告)日：2008-02-07
申请号：US11485575
申请日：2006-07-12
申请人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Robert J. Trotman , Tina K. Van Dyk
发明人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Robert J. Trotman , Tina K. Van Dyk
摘要： TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
摘要翻译： 使用低浓度戊二醛将TAL细胞生物催化剂固定在藻酸盐交联珠粒中。 生物催化剂珠具有高度稳定的TAL活性和机械强度，使得它们在pHCA的生产中经受长时间的再循环。
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公开(公告)号：US20080118958A1
公开(公告)日：2008-05-22
申请号：US11448331
申请日：2006-06-07
CPC分类号： C12P13/225
摘要： An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.
摘要翻译： 使用一步法将肠道细菌菌株设计为过度产生L-酪氨酸。 细菌基因组的pheA-tyrA染色体区被工程染色体片段替代，导致pheA编码区的失活和tyrA编码区的强表达，导致高水平的L-酪氨酸产生。
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4.发明授权Methods for increasing the resistance of a host cell to aromatic carboxylic acids 失效增加宿主细胞对芳香族羧酸的抗性的方法公开(公告)号：US07279321B2
公开(公告)日：2007-10-09
申请号：US10759898
申请日：2004-01-16
CPC分类号： C12P7/40 , C07K14/245
摘要： The invention provides methods of increasing the production of aromatic carboxylic acids from a host cell via manipulation of the yhcRQP operon encoding a family of efflux proteins. Up-regulation of all or a sub-set of the genes in the yhcRQP were additionally found to enhance tolerance to aromatic carboxylic acids toxicity.
摘要翻译： 本发明提供了通过操纵编码一系列外排蛋白的yhcRQP操纵子来增加宿主细胞产生芳族羧酸的方法。 另外发现yhcRQP中全部或一组亚基的上调增强了对芳香族羧酸毒性的耐受性。
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公开(公告)号：US07700328B2
公开(公告)日：2010-04-20
申请号：US11448331
申请日：2006-06-07
CPC分类号： C12P13/225
摘要： An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.
摘要翻译： 使用一步法将肠道细菌菌株设计为过度产生L-酪氨酸。 细菌基因组的pheA-tyrA染色体区被工程染色体片段替代，导致pheA编码区的失活和tyrA编码区的强表达，导致高水平的L-酪氨酸产生。
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6.发明授权Yeast with increased butanol tolerance involving a multidrug efflux pump gene 有权具有增加的丁醇耐受性的酵母涉及多药外排泵基因公开(公告)号：US08614085B2
公开(公告)日：2013-12-24
申请号：US12711308
申请日：2010-02-24
申请人： Tina K. Van Dyk
发明人： Tina K. Van Dyk
摘要： Increasing tolerance to butanol in yeast has been accomplished by decreasing activity of Pdr5p encoded by an endogenous PDR5 gene. A deletion mutation of the PDR5 gene led to improved growth yield in the presence of butanol. Yeast cells with reduced Pdr5p activity, or other multidrug resistance ATP-binding cassette transporter protein activity encoded by CDR1 or BFR1, and a butanol biosynthetic pathway may be used for improved butanol production.
摘要翻译： 通过降低由内源性PDR5基因编码的Pdr5p的活性，可以增加对酵母中丁醇的耐受性。 PDR5基因的缺失突变导致丁醇存在下生长产量提高。 可以使用具有降低的Pdr5p活性的酵母细胞或由CDR1或BFR1编码的其他多药耐药性ATP结合盒转运蛋白活性和丁醇生物合成途径来改善丁醇生产。
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公开(公告)号：US08222000B2
公开(公告)日：2012-07-17
申请号：US12960634
申请日：2010-12-06
申请人： Tina K. Van Dyk
发明人： Tina K. Van Dyk
IPC分类号： C12P21/06
摘要： Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose transporter activity and a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.
摘要翻译： 描述了能够代谢蔗糖的重组细菌。 重组细菌在其基因组或至少一种重组构建体中包含：编码具有蔗糖转运蛋白活性的多肽的地衣芽孢杆菌ATCC 14580的核苷酸序列和编码具有蔗糖水解酶活性的多肽的地衣芽孢杆菌ATCC 14580的核苷酸序列。 这些核苷酸序列各自可操作地连接到相同或不同的启动子。 还描述了能够代谢蔗糖以产生甘油和/或甘油衍生产物如1,3-丙二醇和3-羟基丙酸的重组细菌。
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8.发明授权Strain comprising increased expression of a CFA coding region for butanol production 有权包含增加用于丁醇生产的CFA编码区的表达的菌株公开(公告)号：US08518678B2
公开(公告)日：2013-08-27
申请号：US12330534
申请日：2008-12-09
CPC分类号： C12P7/16 , C12N9/1007 , Y02E50/10
摘要： Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased butanol tolerance. Bacterial strains with increased cyclopropane fatty acid synthase and having a butanol biosynthetic pathway are useful for production of butanol.
摘要翻译： 筛选不是天然丁醇生产者的脂肪酸饲养细菌增加膜环丙烷脂肪酸提供改善的丁醇耐受性。 在酶底物存在下增加环丙烷脂肪酸合酶的表达，该酶底物是细胞内源的或进入细胞，提高了丁醇耐受性。 具有增加的环丙烷脂肪酸合成酶并具有丁醇生物合成途径的细菌菌株可用于生产丁醇。
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公开(公告)号：US08426173B2
公开(公告)日：2013-04-23
申请号：US12110503
申请日：2008-04-28
申请人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
发明人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
IPC分类号： C12P7/16
CPC分类号： C12N15/74 , C12N15/70 , C12P7/16 , C12Y103/01038 , C12Y103/01044 , C12Y402/01017 , C12Y402/01055 , Y02E50/10
摘要： A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.
摘要翻译： 公开了通过使用微生物生产宿主发酵生产1-丁醇的方法。 该方法在发酵过程中使用温度降低，导致生产主体对丁醇产物的更强的耐受性。
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10.发明申请PROCESS FOR THE BIOLOGICAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID WITH HIGH YIELD 审中-公开具有高生产力的3-羟基丙酸生物工艺公开(公告)号：US20110144377A1
公开(公告)日：2011-06-16
申请号：US12815461
申请日：2010-06-15
申请人： Andrew C. Eliot , Tina K. Van Dyk
发明人： Andrew C. Eliot , Tina K. Van Dyk
CPC分类号： C12P7/42 , C12N9/0006 , C12N9/0008 , C12N9/16 , C12N9/88
摘要： The present invention provides a microorganism useful for biologically producing 3-hydroxypropionic acid from a fermentable carbon source. Further, the microorganism comprises disruptions in specified genes and alterations in the expression levels of specified genes that are useful in a higher yielding process to produce 3-hydroxypropionic acid, compositions comprising renewably sourced 3-hydroxypropionic acid provided by said microorganism, and industrial relevant products made using such renewably sourced 3-hydroxypropionic acid.
摘要翻译： 本发明提供可用于从可发酵碳源生物学生产3-羟基丙酸的微生物。 此外，微生物包含特定基因的破坏以及可用于产生3-羟基丙酸的较高产率过程的特定基因的表达水平的改变，包含由所述微生物提供的可再生来源的3-羟基丙酸的组合物和工业相关产品 使用这种可再生来源的3-羟基丙酸制备。
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