公开(公告)号：US20020158022A1

公开(公告)日：2002-10-31

申请号：US10118469

申请日：2002-04-05

Applicant: Fluidigm Corporation

Inventor： Jiang Huang ,  Hou-Pu Chou ,  Marc A. Unger

IPC: B01D015/08

CPC classification number: B01D15/08 ,  G01N30/6065 ,  G01N30/6095 ,  G01N2030/387 ,  G01N2030/521 ,  Y10T137/86863 ,  Y10T436/2575

Abstract: The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.

Abstract translation: 本发明涉及包含微流体输送系统和与流体输送系统流体连通的色谱柱的微流体色谱装置及其制造和使用方法。 优选地，色谱柱包括OTLC，PCLC或其组合。

公开(公告)号：US20020117517A1

公开(公告)日：2002-08-29

申请号：US09998600

申请日：2001-11-16

Applicant: Fluidigm Corporation

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Ian D. Manger ,  Dave Fernandez ,  Yong Yi

IPC: B65D037/00

CPC classification number: B01L3/02 ,  B01L3/0268 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0688 ,  B29C65/006 ,  B29C65/48 ,  B29C66/112 ,  B29C66/1122 ,  B29C66/114 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/1226 ,  B29C66/532 ,  B29C66/54 ,  B29C66/71 ,  B29L2031/756 ,  B81B2201/13 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0017 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N1/14 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  B29K2021/00

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

Abstract translation: 本发明提供了使用该流体装置的微流体装置，系统和方法，其有助于将流体引入到位于微流体装置内的微流体通道和从微流体通道中引入流体。

公开(公告)号：US20020195152A1

公开(公告)日：2002-12-26

申请号：US09995397

申请日：2001-11-26

Applicant: Fluidigm Corporation

Inventor： David N. Fernandes ,  Hou-Pu Chou ,  Marc A. Unger

IPC: F15C001/00

CPC classification number: F15C3/00 ,  A61M2206/22 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/14 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  F15C3/04 ,  F16K99/0001 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0082 ,  F16K2099/0084 ,  G06F17/509 ,  G06F2217/16 ,  H01H2029/008 ,  Y10T137/206 ,  Y10T137/2202 ,  Y10T137/2218 ,  Y10T137/2224 ,  Y10T137/7879 ,  Y10T137/7891 ,  Y10T137/7892

Abstract: The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals. The present invention also includes microfabricated fluidic pressure multipliers that increase the pressure in a second chamber relative to a first chamber. Microfabricated fluidic devices of the present invention also include pressure sources. A pressure source of the present includes a pump coupled to a reservoir through unidirectional valves. The pressure source may be high pressure source or a low pressure source. Microfabricated fluidic devices of the present invention may also include devices that perform analog functions such as switching regulator.

Abstract translation: 本发明提供微制造流体系统和方法。 本发明的微型流体装置包括可以打开和关闭的开关，以响应于开关的门中的压力水平来允许或阻止流体通过通道的流动。 微制造的流体开关可以耦合在一起以执行逻辑功能和布尔代数，例如反相器，与门，NAND，门，NOR门和或门。 逻辑门可以耦合在一起以形成锁存信号的触发器。 本发明还包括相对于第一腔室增加第二腔室中的压力的​​微制造流体压力倍增器。 本发明的微型流体装置还包括压力源。 本发明的压力源包括通过单向阀联接到储存器的泵。 压力源可以是高压源或低压源。 本发明的微型流体装置还可以包括执行诸如开关调节器的模拟功能的装置。

公开(公告)号：US20020160139A1

公开(公告)日：2002-10-31

申请号：US10118467

申请日：2002-04-05

Applicant: Fluidigm Corporation

Inventor： Jiang Huang ,  Shoujun Xiao ,  Marc A. Unger

IPC: B32B001/06 ,  B05D007/22 ,  B05D003/10

CPC classification number: B32B3/26 ,  B01J20/285 ,  B01J20/286 ,  B01J20/327 ,  B01J20/3272 ,  B01J2220/54 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/16 ,  B01L2300/163 ,  C08F257/02 ,  C08F263/04 ,  C08F265/04 ,  C08F279/02 ,  C08F287/00 ,  C08F291/00 ,  C08J5/12 ,  C08J7/12 ,  F04B43/043 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/24661 ,  Y10T428/24744 ,  Y10T428/249953 ,  Y10T428/249958 ,  Y10T428/249978 ,  Y10T428/31663 ,  Y10T428/31667

Abstract: The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

Abstract translation: 本发明涉及包含与表面改性化合物共价结合的表面的表面改性聚合物。 通过聚合物中存在的固有官能团和表面改性化合物的官能团之间的反应可以实现聚合物与表面改性化合物之间的共价键的形成。 通过使用具有固有官能团的聚合物，避免了单独的表面活化步骤。