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1.发明授权Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists 失效磺酰喹诺酮衍生物和相关化合物作为缓激肽拮抗剂公开(公告)号：US07635775B2
公开(公告)日：2009-12-22
申请号：US11429656
申请日：2006-05-05
申请人： Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
发明人： Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
IPC分类号： A61K31/498 , C07D241/50 , A61P11/06 , A61P25/06 , A61P25/02
CPC分类号： C07D401/14 , C07D241/44 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
摘要翻译： 公开了用作缓激肽拮抗剂的磺酰基喹喔啉乙酰胺衍生物。
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2.发明授权Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists 失效磺酰喹诺酮衍生物和相关化合物作为缓激肽拮抗剂公开(公告)号：US07183281B2
公开(公告)日：2007-02-27
申请号：US10429917
申请日：2003-05-02
申请人： Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
发明人： Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D413/00
CPC分类号： C07D401/14 , C07D241/44 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Disclosed are sulfonylquinoxalone derivatives of the general formula: These compounds are useful as bradykinin antagonists.
摘要翻译： 公开了以下通式的磺酰基喹诺酮衍生物：这些化合物可用作缓激肽拮抗剂。
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公开(公告)号：US20060293332A1
公开(公告)日：2006-12-28
申请号：US11429656
申请日：2006-05-05
申请人： Francine Grant , Sarah Bartulis , Louis Brogley , Michael Dappen , Ramesh Kasar , Mohammed Khan , Martin Neitzel , Michael Pleiss , Eugene Thorsett , John Tucker , Michael Ye , Jon Hawkinson
发明人： Francine Grant , Sarah Bartulis , Louis Brogley , Michael Dappen , Ramesh Kasar , Mohammed Khan , Martin Neitzel , Michael Pleiss , Eugene Thorsett , John Tucker , Michael Ye , Jon Hawkinson
IPC分类号： A61K31/498 , C07D241/36
CPC分类号： C07D401/14 , C07D241/44 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
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公开(公告)号：US20050239790A1
公开(公告)日：2005-10-27
申请号：US11075294
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , John Tucker , Barbara Jagodzinska , Louis Brogley , Jay Tung , Neerav Shah , R. Neitz
发明人： Varghese John , Michel Maillard , John Tucker , Barbara Jagodzinska , Louis Brogley , Jay Tung , Neerav Shah , R. Neitz
IPC分类号： A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4747 , A61K31/4965 , C07C215/70 , C07C237/20 , C07D233/54 , C07D257/04 , C07D263/32 , C07D285/00 , C07D285/12 , C07D285/135 , C07D333/20 , C07D333/24 , C07D405/12 , C07D413/06 , C07D417/12
CPC分类号： C07D333/24 , C07C211/40 , C07C215/44 , C07C215/70 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D233/64 , C07D257/04 , C07D263/32 , C07D285/08 , C07D285/135 , C07D333/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/12
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新化合物，还涉及使用这些化合物治疗与淀粉样变性相关的至少一种疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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5.发明申请Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors 审中-公开使用双环天冬氨酰蛋白酶抑制剂治疗淀粉样变性的方法公开(公告)号：US20050239832A1
公开(公告)日：2005-10-27
申请号：US11074828
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , Lawrence Fang , John Tucker , Louis Brogley , Jose Aquino , Simeon Bowers , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Lawrence Fang , John Tucker , Louis Brogley , Jose Aquino , Simeon Bowers , Gary Probst , Jay Tung
IPC分类号： A61K31/137 , A61K31/35 , A61K31/381 , A61K31/445 , A61K31/47
CPC分类号： A61K31/137 , A61K31/35 , A61K31/381 , A61K31/445 , A61K31/47
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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公开(公告)号：US07858642B2
公开(公告)日：2010-12-28
申请号：US12396989
申请日：2009-03-03
申请人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay S. Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
发明人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay S. Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
IPC分类号： A61K31/427 , A61K31/4709 , C07D215/58 , C07D285/04
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新化合物，还涉及使用这些化合物治疗与淀粉样变性相关的至少一种疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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公开(公告)号：US20050239836A1
公开(公告)日：2005-10-27
申请号：US11075312
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
发明人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
IPC分类号： A61K31/382 , A61K31/453 , C07D207/32 , C07D207/325 , C07D233/54 , C07D257/04 , C07D335/06 , C07D403/12 , C07D405/12 , C07D419/12 , C07D49/02
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
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公开(公告)号：US07759382B2
公开(公告)日：2010-07-20
申请号：US10559823
申请日：2004-06-04
申请人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W. G. Wone
发明人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W. G. Wone
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.
摘要翻译： 本发明涉及酰化氨基酸酰氨基吡唑和式I的相关化合物。本发明还涉及包含这种化合物或其药学上可接受的盐形式的药物组合物。 本发明进一步涉及一种抑制β-淀粉样蛋白肽释放和/或合成的方法，一种抑制γ-分泌酶活性的方法，以及用于治疗与β-淀粉样蛋白肽生产相关的神经障碍的方法。 该方法包括向宿主施用包含有效量的式I化合物的药物制剂。式I化合物可用于预防和治疗阿尔茨海默氏病。
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公开(公告)号：US20100280066A1
公开(公告)日：2010-11-04
申请号：US12833758
申请日：2010-07-09
申请人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W.G. Wone
发明人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W.G. Wone
IPC分类号： A61K31/4725 , C07D231/38 , C07D401/12 , C07D407/04 , C07D401/04 , C07D403/12 , A61P25/28 , A61K31/415 , A61K31/4439 , A61K31/454 , C12N5/07
CPC分类号： C07D231/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.
摘要翻译： 本发明涉及酰化氨基酸酰氨基吡唑和式I的相关化合物。本发明还涉及包含这种化合物或其药学上可接受的盐形式的药物组合物。 本发明进一步涉及一种抑制β-淀粉样蛋白肽释放和/或合成的方法，一种抑制γ-分泌酶活性的方法，以及用于治疗与β-淀粉样蛋白肽生产相关的神经障碍的方法。 该方法包括向宿主施用包含有效量的式I化合物的药物制剂。式I化合物可用于预防和治疗阿尔茨海默氏病。
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公开(公告)号：US12009116B2
公开(公告)日：2024-06-11
申请号：US16891584
申请日：2020-06-03
CPC分类号： H01B11/1895 , H01R9/05
摘要： In some embodiments, a noise reduction circuit comprises an insulated wire comprising a conductor and insulation. A shielding material is oriented around the insulated wire. The shielding material comprises metallized fibers.
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