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1.发明申请Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors 审中-公开使用双环天冬氨酰蛋白酶抑制剂治疗淀粉样变性的方法公开(公告)号：US20050239832A1
公开(公告)日：2005-10-27
申请号：US11074828
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , Lawrence Fang , John Tucker , Louis Brogley , Jose Aquino , Simeon Bowers , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Lawrence Fang , John Tucker , Louis Brogley , Jose Aquino , Simeon Bowers , Gary Probst , Jay Tung
IPC分类号： A61K31/137 , A61K31/35 , A61K31/381 , A61K31/445 , A61K31/47
CPC分类号： A61K31/137 , A61K31/35 , A61K31/381 , A61K31/445 , A61K31/47
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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公开(公告)号：US20050239836A1
公开(公告)日：2005-10-27
申请号：US11075312
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
发明人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
IPC分类号： A61K31/382 , A61K31/453 , C07D207/32 , C07D207/325 , C07D233/54 , C07D257/04 , C07D335/06 , C07D403/12 , C07D405/12 , C07D419/12 , C07D49/02
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
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公开(公告)号：US07858642B2
公开(公告)日：2010-12-28
申请号：US12396989
申请日：2009-03-03
申请人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay S. Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
发明人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay S. Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
IPC分类号： A61K31/427 , A61K31/4709 , C07D215/58 , C07D285/04
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新化合物，还涉及使用这些化合物治疗与淀粉样变性相关的至少一种疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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4.发明申请OXIME DERIVATIVE SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS 审中-公开OXIME衍生的取代羟基乙酰胺ASPARTYL蛋白酶抑制剂公开(公告)号：US20090042961A1
公开(公告)日：2009-02-12
申请号：US12117094
申请日：2008-05-08
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
IPC分类号： A61K31/165 , A61P43/00 , C07D257/04 , C07C233/36 , C07C243/20 , C07D405/10 , A61K31/4155 , A61K31/41 , C07D231/12 , A61K31/415 , C07D231/54 , A61K31/416
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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5.发明申请Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors 失效肟衍生物取代的羟乙基胺天冬氨酰蛋白酶抑制剂公开(公告)号：US20070149584A9
公开(公告)日：2007-06-28
申请号：US11177324
申请日：2005-07-11
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
IPC分类号： A61K31/42 , A61K31/416 , A61K31/165
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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6.发明申请Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors 失效肟衍生物取代的羟乙基胺天冬氨酰蛋白酶抑制剂公开(公告)号：US20060135581A1
公开(公告)日：2006-06-22
申请号：US11177324
申请日：2005-11-17
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
IPC分类号： A61K31/42 , A61K31/416 , A61K31/165
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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7.发明授权Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors 失效肟衍生物取代的羟乙基胺天冬氨酰蛋白酶抑制剂公开(公告)号：US07385085B2
公开(公告)日：2008-06-10
申请号：US11177324
申请日：2005-07-11
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
IPC分类号： C07C237/04
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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公开(公告)号：US20050239790A1
公开(公告)日：2005-10-27
申请号：US11075294
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , John Tucker , Barbara Jagodzinska , Louis Brogley , Jay Tung , Neerav Shah , R. Neitz
发明人： Varghese John , Michel Maillard , John Tucker , Barbara Jagodzinska , Louis Brogley , Jay Tung , Neerav Shah , R. Neitz
IPC分类号： A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4747 , A61K31/4965 , C07C215/70 , C07C237/20 , C07D233/54 , C07D257/04 , C07D263/32 , C07D285/00 , C07D285/12 , C07D285/135 , C07D333/20 , C07D333/24 , C07D405/12 , C07D413/06 , C07D417/12
CPC分类号： C07D333/24 , C07C211/40 , C07C215/44 , C07C215/70 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D233/64 , C07D257/04 , C07D263/32 , C07D285/08 , C07D285/135 , C07D333/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/12
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及新化合物，还涉及使用这些化合物治疗与淀粉样变性相关的至少一种疾病，病症或病症的方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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9.发明申请Substituted urea and carbamate, phenacyl-2-hydroxy-3-diaminoalkane, and benzamide-2-hydroxy-3-diaminoalkane aspartyl-protease inhibitors 审中-公开取代的脲和氨基甲酸酯，苯甲酰甲基-2-羟基-3-二氨基烷烃和苯甲酰胺-2-羟基-3-二氨基烷烃天冬氨酰蛋白酶抑制剂公开(公告)号：US20050261273A1
公开(公告)日：2005-11-24
申请号：US11075292
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Roy Hom , Jay Tung , Darren Dressen , Neerav Shah , R. Neitz
发明人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Roy Hom , Jay Tung , Darren Dressen , Neerav Shah , R. Neitz
IPC分类号： A61K31/16 , A61K31/40 , A61K31/445 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/553 , C07C215/28 , C07C229/42 , C07C229/60 , C07C233/40 , C07C235/10 , C07C235/42 , C07C235/74 , C07C235/82 , C07C237/14 , C07C237/30 , C07C239/16 , C07C255/34 , C07C275/06 , C07C275/14 , C07C275/26 , C07C275/28 , C07C311/03 , C07C311/05 , C07C311/07 , C07C311/08 , C07C323/30 , C07C323/59 , C07C327/46 , C07D205/04 , C07D207/16 , C07D207/28 , C07D209/12 , C07D209/18 , C07D211/56 , C07D211/58 , C07D211/94 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/30 , C07D233/46 , C07D233/54 , C07D233/76 , C07D233/90 , C07D239/26 , C07D241/24 , C07D257/04 , C07D261/08 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/14 , C07D277/28 , C07D277/56 , C07D307/00 , C07D307/24 , C07D307/54 , C07D307/68 , C07D309/14 , C07D311/96 , C07D317/72 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D335/06 , C07D405/10 , C07D407/12 , C07F9/40
CPC分类号： C07D335/06 , A61K31/16 , C07C215/28 , C07C229/42 , C07C229/60 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/74 , C07C235/82 , C07C237/30 , C07C239/16 , C07C255/34 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/26 , C07C311/03 , C07C311/05 , C07C311/07 , C07C311/08 , C07C323/30 , C07C323/59 , C07C327/46 , C07C2601/02 , C07C2601/10 , C07C2601/14 , C07C2602/10 , C07C2603/74 , C07D205/04 , C07D207/16 , C07D207/28 , C07D209/12 , C07D209/18 , C07D209/42 , C07D211/56 , C07D211/58 , C07D211/94 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/30 , C07D233/46 , C07D233/58 , C07D233/64 , C07D233/76 , C07D233/90 , C07D239/26 , C07D241/24 , C07D257/04 , C07D261/08 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/14 , C07D277/24 , C07D277/28 , C07D277/56 , C07D307/00 , C07D307/24 , C07D307/54 , C07D307/68 , C07D309/14 , C07D311/96 , C07D317/72 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D405/10 , C07D407/12 , C07F9/4006
摘要： The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及可用于治疗与淀粉样变性相关的至少一种疾病，病症和状况的乙酰基2-羟基-1,3-二氨基螺环己烷及其衍生物。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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10.发明申请Methods of treatment of amyloidosis using spirocyclohexane aspartyl-protease inhibitors 审中-公开使用螺环己烷天冬氨酰蛋白酶抑制剂治疗淀粉样变性的方法公开(公告)号：US20060014790A1
公开(公告)日：2006-01-19
申请号：US11038790
申请日：2005-01-21
申请人： Varghese John , Roy Hom , Jennifer Sealy , Jose Aquino , Gary Probst , Jay Tung , Lawrence Fang
发明人： Varghese John , Roy Hom , Jennifer Sealy , Jose Aquino , Gary Probst , Jay Tung , Lawrence Fang
IPC分类号： A61K31/445 , A61K31/38 , A61K31/165 , A61K31/381
CPC分类号： A61K31/38 , A61K31/165 , A61K31/381 , A61K31/445
摘要： The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译： 本发明涉及可用于治疗与淀粉样变性相关的疾病，病症和病症的乙酰基2-羟基-1,3-二氨基螺环己烷及其衍生物。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。
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