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    ENDOTHELIAL BASEMENT MEMBRANE TARGETING PEPTIDE LIGANDS
    3.
    发明申请
    ENDOTHELIAL BASEMENT MEMBRANE TARGETING PEPTIDE LIGANDS 审中-公开
    内皮基底膜定向肽配体

    公开(公告)号：US20110143993A1

    公开(公告)日：2011-06-16

    申请号：US12969345

    申请日：2010-12-15

    申请人： Robert S. Langer ,  Omid C. Farokhzad ,  Juliana M. Chan

    发明人： Robert S. Langer ,  Omid C. Farokhzad ,  Juliana M. Chan

    IPC分类号： A61K38/08 ,  C07K7/06 ,  A61P35/00 ,  A61P27/02 ,  A61P9/10 ,  A61P7/00 ,  G01N33/68

    CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/59 ,  A61K47/593 ,  A61K47/66 ,  A61K47/6911 ,  A61K47/6935 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2800/00

    摘要： Peptides that selectively bind to antigens exposed in vascular disease or dysfunction have been identified by biopanning a phage library. The ligands are useful when attached to a substrate to be in contact with endothelial surfaces, especially those where drug delivery is utilized, such as following angioplasty, with release from a drug delivery reservoir in a medical device such as a stent, or by administration intravenously in the form of nano or microparticles, although the peptides may also be used with other medical devices or substrates, for targeting or to increase adhesion to endothelial surfaces. The nanoparticle technology can be used to treat injured vasculature, a clinical problem of primary importance. The targeted nanoparticles are also useful in the treatment of other diseases and disorders such as oncologic and regenerative diseases and indications where neoangiogenesis is commonly observed.

    摘要翻译： 已经通过生物淘选噬菌体文库鉴定了选择性结合暴露在血管疾病或功能障碍中的抗原的肽。 当附着于与内皮表面接触的底物时，配体是有用的，特别是那些使用药物递送的那些，例如随后的血管成形术，从医疗装置例如支架中的药物递送储存器释放，或通过静脉内施用 以纳米或微粒的形式，尽管肽也可以与其它医疗装置或底物一起使用，用于靶向或增加对内皮表面的粘附。 纳米颗粒技术可用于治疗受伤的脉管系统，这是一个首要重要的临床问题。 目标纳米颗粒还可用于治疗其他疾病和病症，例如肿瘤和再生疾病和通常观察到血管生成的适应症。

    Vaccine Nanotechnology
    5.
    发明申请
    Vaccine Nanotechnology 审中-公开
    疫苗纳米技术

    公开(公告)号：US20100233251A1

    公开(公告)日：2010-09-16

    申请号：US12681814

    申请日：2008-10-12

    申请人： Ulrich H. Von Andrian ,  Omid C. Farokhzad ,  Robert S. Langer ,  Tobias Junt ,  Ashley Moseman ,  Liangfang Zhang ,  Pamela Basto ,  Matteo Iannacone ,  Frank Alexis

    发明人： Ulrich H. Von Andrian ,  Omid C. Farokhzad ,  Robert S. Langer ,  Tobias Junt ,  Ashley Moseman ,  Liangfang Zhang ,  Pamela Basto ,  Matteo Iannacone ,  Frank Alexis

    IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K39/00

    摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

    摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。

    DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION
    10.
    发明申请
    DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION 审中-公开
    用于药物和辐射的药物递送系统

    公开(公告)号：US20110027172A1

    公开(公告)日：2011-02-03

    申请号：US12747040

    申请日：2008-12-10

    申请人： Zhuang Wang ,  Omid C. Farokhzad ,  Liangfang Zhang ,  Aleksandar Filip Radovic-Moreno ,  Frank X. Gu ,  Robert S. Langer

    发明人： Zhuang Wang ,  Omid C. Farokhzad ,  Liangfang Zhang ,  Aleksandar Filip Radovic-Moreno ,  Frank X. Gu ,  Robert S. Langer

    IPC分类号： A61K51/12 ,  A61K9/14 ,  A61K9/00 ,  A61P43/00

    CPC分类号： A61K51/1255 ,  A61K31/337 ,  A61K47/6937

    摘要： The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.

    摘要翻译： 本发明提供了用于递送药剂和放射性药剂的药物递送系统。 药物递送系统可以特异性地靶向器官，组织，细胞，细胞外基质或细胞内区室。 通常，药物递送系统是颗粒。 还提供了包含本发明颗粒的药物组合物。 本发明提供了制备和使用本发明的颗粒和药物组合物的方法。 本发明的颗粒可用于治疗和诊断各种疾病，包括癌症。 本发明的颗粒也可用于在体内追踪颗粒。