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    Biodegradable matrix and methods for producing same
    2.
    发明授权
    Biodegradable matrix and methods for producing same 失效
    可生物降解基质及其制备方法

    公开(公告)号：US4703108A

    公开(公告)日：1987-10-27

    申请号：US843828

    申请日：1986-03-26

    申请人： Frederick A. Silver ,  Richard A. Berg ,  David E. Birk ,  Kevin Weadock ,  Conrad Whyne

    发明人： Frederick A. Silver ,  Richard A. Berg ,  David E. Birk ,  Kevin Weadock ,  Conrad Whyne

    IPC分类号： A01N25/10 ,  A61F2/10 ,  A61F13/00 ,  A61K20060101 ,  A61K9/00 ,  A61K9/22 ,  A61K9/70 ,  A61K47/00 ,  A61L20060101 ,  A61L15/00 ,  A61L15/32 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L17/00 ,  A61L26/00 ,  A61L27/24 ,  A61L27/56 ,  A61L27/58 ,  C08H20060101 ,  C08H1/00 ,  C08L89/00 ,  C08L89/06 ,  C09H1/00 ,  A23J1/10 ,  C08H1/06

    CPC分类号： A61L15/425 ,  A61K9/70 ,  A61L15/325 ,  A61L15/44 ,  A61L15/64 ,  A61L26/0033 ,  A61L27/24 ,  A61L27/56 ,  A61L27/58 ,  C08L89/06 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/434 ,  Y10S128/08 ,  Y10S514/801

    摘要： There are disclosed processes for preparing biodegradable collagen-based matrices in sponge or sheet form wherein in one embodiment a collagen-based material including a collagen selected from the group consisting of types I, II and II collagens is freeze dried to form a collagen-based sponge which is contacted with a cross-linking agent selected from the group consisting of a carbodiimide or a succinimidyl active ester to form an intermediate collagen-based matrix which is subsequently subjected to conditions of severe dehydration to form the collagen-based matrix in sponge or sheet form. In another embodiment, a collagen-based sponge or sheet is first subjected to conditions of severe dehydration followed by contacting the thus formed intermediate collagen-based matrix with a carbodiimide crosslinking compound to form the collagen-based matrix in sponge or sheet form. In still another embodiment of the present invention the cross-linking agent is admixed with the collagen-based material prior to formation of the collagen-based sponge or sheet followed by processing steps of severe dehydration. In a particularly preferred form of the invention, a carrier compound is incorporated during processing to form a collagen-based matrix in sponge or sheet form impregnated with a carrier compound wherein the carrier compound is selected from the group consisting of types IV and V collagen, fibronectin, laminin, hyaluronate, proteoglycan, epidermal growth factor, platelet derived growth factor, angiogenesis factor, antibiotic, antifungal agent, spermacidal agent, enzyme and enzyme inhibitor.

    摘要翻译： 公开了以海绵或片状形式制备可生物降解的基于胶原的基质的方法，其中在一个实施方案中，将包含选自I，II和II型胶原蛋白的胶原蛋白的基于胶原的材料冷冻干燥以形成基于胶原的 海绵，其与选自碳二亚胺或琥珀酰亚胺基活性酯的交联剂接触以形成中间胶原基质，其随后经历严重脱水条件以在海绵中形成基于胶原的基质，或 表单。 在另一个实施方案中，基于胶原的海绵或片材首先经受严重脱水的条件，然后使由此形成的中间胶原基质与碳二亚胺交联化合物接触以形成海绵或片状形式的基于胶原的基质。 在本发明的另一个实施方案中，在形成基于胶原的海绵或片材之前将交联剂与基于胶原的材料混合，然后进行严重脱水的加工步骤。 在本发明的特别优选形式中，在加工过程中加入载体化合物以形成浸渍有载体化合物的海绵或片状形式的基于胶原的基质，其中载体化合物选自IV型和V型胶原， 纤连蛋白，层粘连蛋白，透明质酸，蛋白聚糖，表皮生长因子，血小板衍生生长因子，血管生成因子，抗生素，抗真菌剂，精子拮抗剂，酶和酶抑制剂。

    Methods and Devices for Preventing Catheter Related Urinary Tract Infections
    3.
    发明申请
    Methods and Devices for Preventing Catheter Related Urinary Tract Infections 有权
    用于预防导管相关泌尿道感染的方法和装置

    公开(公告)号：US20120203211A1

    公开(公告)日：2012-08-09

    申请号：US13023724

    申请日：2011-02-09

    申请人： Kevin Weadock ,  Amit Khanolkar

    发明人： Kevin Weadock ,  Amit Khanolkar

    IPC分类号： A61L29/16 ,  A61M27/00

    CPC分类号： A61M25/0017 ,  A61L29/145 ,  A61L29/16 ,  A61L2300/404 ,  A61M2025/0019 ,  A61M2025/0056

    摘要： Methods and devices for preventing urinary tract infections in catheterized patients are disclosed. The device may be a cylindrically shaped antimicrobial hydrogel having a central opening and a slit along its length so that it can be applied directly over a previously inserted urinary catheter. An optional locking mechanism disposed about the slit can be used to secure the antimicrobial device to a catheter shaft. The antimicrobial device has features that conform to tissues near both male and female urethral openings. The inner surface of the device is adapted to provide for releasable engagement with the shaft of the urinary catheter. In one embodiment, the device may be placed on a urinary catheter prior to inserting the catheter in a patient. Locking fittings to secure the antimicrobial device against the urethral opening may also be used. Antimicrobial agents can be incorporated within the hydrogel or coated onto its surface.

    摘要翻译： 公开了用于预防导尿患者尿路感染的方法和装置。 该装置可以是圆柱形的抗微生物水凝胶，其具有沿其长度的中心开口和狭缝，​​使得其可以直接施加在先前插入的导尿管上。 可以使用围绕狭缝设置的可选的锁定机构来将抗微生物装置固定到导管轴上。 抗微生物装置具有符合男性和女性尿道口附近的组织的特征。 该装置的内表面适于提供与导尿管的轴可释放接合。 在一个实施例中，在将导管插入患者体内之前，可将该装置放置在导尿管上。 还可以使用锁定配件以将抗微生物装置固定在尿道开口处。 抗微生物剂可以掺入水凝胶中或涂覆在其表面上。

    Methods and devices for treating vulnerable plaque
    4.
    发明申请
    Methods and devices for treating vulnerable plaque 有权
    治疗易损斑块的方法和装置

    公开(公告)号：US20070123839A1

    公开(公告)日：2007-05-31

    申请号：US11290780

    申请日：2005-11-30

    申请人： Robert Rousseau ,  Kevin Weadock

    发明人： Robert Rousseau ,  Kevin Weadock

    IPC分类号： A61N1/30

    CPC分类号： A61B17/22 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12136 ,  A61B17/12181 ,  A61B2017/00893 ,  A61B2017/22082 ,  A61M25/1002

    摘要： This invention provides methods, devices and kits for treating coronary artery disease, particularly “soft” or vulnerable plaque. The invention is based on the local delivery of crosslinking means to crosslink the collagen covering the plaque and other proteins that may be present at the site to stabilize the plaque and prevent leakage of thrombogenic material into the lumen of the coronary artery. In certain embodiments, catheters are employed to achieve local delivery of a crosslinking agent or ultraviolet light.

    摘要翻译： 本发明提供用于治疗冠状动脉疾病，特别是“软”或易损斑块的方法，装置和试剂盒。 本发明基于交联手段的局部递送，以交联覆盖斑块的胶原和可能存在于该部位的其它蛋白质以稳定斑块并防止血栓形成物质渗入冠状动脉的内腔。 在某些实施方案中，导管用于实现交联剂或紫外线的局部递送。

    Methods and devices for forming an auxiliary airway for treating obstructive sleep apnea
    6.
    发明授权
    Methods and devices for forming an auxiliary airway for treating obstructive sleep apnea 有权
    用于形成用于治疗阻塞性睡眠呼吸暂停的辅助气道的方法和装置

    公开(公告)号：US08678008B2

    公开(公告)日：2014-03-25

    申请号：US12182402

    申请日：2008-07-30

    申请人： Robert A. Rousseau ,  Kevin Weadock

    发明人： Robert A. Rousseau ,  Kevin Weadock

    IPC分类号： A61F5/56

    CPC分类号： A61F5/566 ,  A61F2/20 ,  A61F2/82 ,  A61F2/94 ,  A61F2230/0008 ,  A61F2230/0013

    摘要： An auxiliary airway for treating obstructive sleep apnea is formed by implanting an elongated conduit beneath a pharyngeal wall of a pharynx. The elongated conduit has a proximal end in communication with a first region of the pharynx, a distal end in communication with a second region of the pharynx, and a section extending beneath the pharyngeal wall for bypassing an oropharynx region of the pharynx. The system includes a first opening in the pharyngeal wall in communication with a first opening in the elongated conduit, and a second opening in the pharyngeal wall in communication with a second opening in the elongated conduit. The system has a first anastomotic connector for coupling the first opening in the pharyngeal wall with the first opening in the conduit, and a second anastomotic connector for coupling the second opening in the pharyngeal wall with the second opening in the conduit.

    摘要翻译： 用于治疗阻塞性睡眠呼吸暂停的辅助气道通过在咽部的咽壁下方植入细长导管而形成。 所述细长管道具有与所述咽部的第一区域连通的近端，与所述咽部的第二区域连通的远端以及在所述咽壁下方延伸以用于绕开所述咽口咽部区域的部分。 所述系统包括与所述细长导管中的第一开口连通的咽壁中的第一开口，以及与所述细长导管中的第二开口连通的所述咽壁中的第二开口。 该系统具有用于将咽壁中的第一开口与导管中的第一开口联接的第一吻合连接器，以及用于将咽壁中的第二开口与导管中的第二开口联接的第二吻合连接器。

    Antimicrobial dressing providing percutaneous device securement and cover
    10.
    发明授权
    Antimicrobial dressing providing percutaneous device securement and cover 有权
    提供经皮装置固定和覆盖的抗微生物敷料

    公开(公告)号：US09238123B2

    公开(公告)日：2016-01-19

    申请号：US12952628

    申请日：2010-11-23

    申请人： Kevin Weadock ,  Leo B. Kriksunov

    发明人： Kevin Weadock ,  Leo B. Kriksunov

    IPC分类号： A61M25/02 ,  A61M25/00

    CPC分类号： A61M25/02 ,  A61M2025/0056 ,  A61M2025/0253 ,  A61M2025/0273 ,  A61M2025/028

    摘要： The present invention is related to a polymeric vehicle for delivery of bioactive agents, and preferably, for the delivery of one or more bioactive agents. The invention is also directed to a percutaneous device securing and drug delivery device comprising, as a component thereof, a material which delivers antimicrobial and/or other wound-healing factors at the site of the insertion of the catheter into the body. The device, when applied as described herein, provides complete anti-microbial coverage around the entry point of a percutaneous device and, preferably for a length greater than the diameter of the device. The present invention is also directed to methods for using such devices in combination with percutaneous devices primarily to reduce site infections.

    摘要翻译： 本发明涉及用于递送生物活性剂的聚合物载体，优选用于递送一种或多种生物活性剂。 本发明还涉及一种经皮装置固定和药物输送装置，其包括在将导管插入体内的位置处递送抗微生物和/或其它伤口愈合因子作为其组分的材料。 当如本文所述施用时，该装置在经皮装置的入口点附近提供完整的抗微生物覆盖，并且优选地大于装置的直径的长度。 本发明还涉及将这些装置与经皮装置结合使用的方法，主要用于减少局部感染。