利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

22 条记录 (耗时 0.024 秒)

    Method and device for manipulating microparticles in fluid flows
    1.
    发明授权
    Method and device for manipulating microparticles in fluid flows 有权
    用于操纵流体流中微粒的方法和装置

    公开(公告)号：US06727451B1

    公开(公告)日：2004-04-27

    申请号：US09673034

    申请日：2000-11-30

    申请人： Günter Fuhr ,  Rolf Hagedorn ,  Torsten Müller ,  Thomas Schnelle ,  Gabriele Gradl

    发明人： Günter Fuhr ,  Rolf Hagedorn ,  Torsten Müller ,  Thomas Schnelle ,  Gabriele Gradl

    IPC分类号： B01D5702

    CPC分类号： B03C5/026 ,  C12M47/04

    摘要： To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.

    摘要翻译： 为了操纵在与第一通道或多个第一通道相交的流体中的微粒作为流，一个或多个微粒暴露于电场屏障，其将其方向从流动方向朝向流动边缘改变为侧向 （17）。 结果，微粒可以在流动流体之间来回移动。 优选的应用包括处理，分离，分选或限制程序。

    Method and device for measuring, calibrating and using laser tweezers
    5.
    发明授权
    Method and device for measuring, calibrating and using laser tweezers 失效
    用于测量，校准和使用激光镊子的方法和装置

    公开(公告)号：US06991906B1

    公开(公告)日：2006-01-31

    申请号：US09582609

    申请日：1998-12-21

    申请人： Günter Fuhr ,  Thomas Schnelle ,  Torsten Müller ,  Hermine Hitzler ,  Karl-Otto Greulich ,  Shamoi Monajembashi

    发明人： Günter Fuhr ,  Thomas Schnelle ,  Torsten Müller ,  Hermine Hitzler ,  Karl-Otto Greulich ,  Shamoi Monajembashi

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： H05H3/04 ,  G21K1/006

    摘要： To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical field that has a field gradient which forms an electrical capture area, and the focus is at a distance from the capture are and b) the amplitude of the electrical field, the light power of the light beam forming the optical cage, and/or the distance of the capture area from the focus are varied to detect which varied field property moves the particle from the focus to the capture area or vice versa, or at least to temporarily move the particle into the capture area.

    摘要翻译： 为了在光学保持架的焦点的至少一个颗粒上测量或施加光学诱导的力，采取以下步骤：a）焦点位于具有场梯度的三维电场的微电极布置中， 形成电捕获区域，并且聚焦距离捕获的距离为b）电场的幅度，形成光学笼的光束的光功率和/或捕获区域距离 改变焦点以检测哪个变化的场性质将粒子从焦点移动到捕获区域，反之亦然，或至少临时将颗粒移动到捕获区域中。

    Process and device for the detection of microscopically small objects
    6.
    发明授权
    Process and device for the detection of microscopically small objects 有权
    检测微小物体的过程和设备

    公开(公告)号：US06801311B1

    公开(公告)日：2004-10-05

    申请号：US09889908

    申请日：2001-12-12

    申请人： Günter Fuhr ,  Thomas Schnelle ,  Christoph Reichle ,  Henning Glasser ,  Torsten Müller

    发明人： Günter Fuhr ,  Thomas Schnelle ,  Christoph Reichle ,  Henning Glasser ,  Torsten Müller

    IPC分类号： G01N1502

    CPC分类号： B03C5/028 ,  B03C5/026 ,  G01N15/1031 ,  G01N15/1056 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/105 ,  G01N2015/1075 ,  G01N2015/1415 ,  G01N2015/1447 ,  G01N2015/1495

    摘要： For object detection, particularly in fluidic microsystems, optical imaging of at least one resting or moving object (10) on a structured mask (20) with at least one segment from a flat section (80), in which the object (10) is located at least partially or temporarily and which has a characteristic dimension smaller than the dimension of the object (10) or its movement path, to a detector unit, detection of the quantity of light transmitted by the structured mask (20), and generation of a detector signal which has a predetermined relationship with the quantity of light, and evaluation of the detector signal in regard to the presence of the object (10), its position, its shape and/or the temporal change of the position are performed.

    摘要翻译： 对于物体检测，特别是在流体微系统中，至少一个静止或移动的物体（10）在结构化掩模（20）上的光学成像，其具有来自平坦部分（80）的至少一个部分，其中物体（10） 至少部分地或临时地定位，并且具有比物体（10）或其移动路径的尺寸小的特征尺寸，到检测器单元，由结构化掩模（20）传输的光量的检测，以及 执行与光量具有预定关系的检测器信号，以及关于物体（10）的存在，其位置，形状和/或位置的时间变化的检测器信号的评估。

    Method and device for manipulating particles in microsystems
    7.
    发明授权
    Method and device for manipulating particles in microsystems 失效
    在微系统中操纵粒子的方法和装置

    公开(公告)号：US06465225B1

    公开(公告)日：2002-10-15

    申请号：US09720219

    申请日：2001-02-22

    申请人： Günter Fuhr ,  Rolf Hagedorn

    发明人： Günter Fuhr ,  Rolf Hagedorn

    IPC分类号： C12N1300

    CPC分类号： B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/0825 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0424 ,  B01L2400/0457 ,  B03C5/026 ,  Y10S977/904

    摘要： For manipulation of particles in a fluidic microsystem (15) in which the particles are moved in a predetermined reference direction in a suspension liquid, the microsystem (15) is closed off at least at its end (17a, 17b) pointing to the reference direction. The particles move under the influence of centrifugal forces and/or gravitational forces in the suspension liquid which is stationary in relation to the microsystem (15), with the centrifugal forces and/or gravitational forces essentially extending parallel to the reference direction. Furthermore, the particles in the microsystem (15) are exposed to deflection forces whose direction differs from that of the reference direction. (FIG. 1).

    摘要翻译： 为了在流体微系统（15）中处理颗粒，其中颗粒在悬浮液体中以预定的参考方向移动，微系统（15）至少在其指向参考方向的端部（17a，17b）处被封闭 。 在离心力和/或重力作用下，颗粒在离心力和/或重力基本上平行于参考方向延伸的悬浮液中相对于微系统（15）静止的运动。 此外，微系统（15）中的颗粒暴露于方向不同于参考方向的偏转力。 （图。1）。

    Method and device for a accomodating samples on cryosubstrates
    9.
    发明授权
    Method and device for a accomodating samples on cryosubstrates 有权
    用于在低温底物上容纳样品的方法和装置

    公开(公告)号：US06646238B1

    公开(公告)日：2003-11-11

    申请号：US10009911

    申请日：2002-03-19

    申请人： Günter Fuhr ,  Rolf Hagedorn

    发明人： Günter Fuhr ,  Rolf Hagedorn

    IPC分类号： H05B306

    CPC分类号： G01N1/42

    摘要： For sample picking on a cryosubstrate, on which multiple cryopreserved samples are each positioned at preselected sample positions, individual samples are selectively separated mechanically or thermally from the cryosubstrate and transferred to a target substrate.

    摘要翻译： 对于低温基板上的样品采集，多个冷冻保存样品各自定位在预先选定的样品位置，单独的样品选择性地与冷冻底物分离或分离，并转移到靶基质。

    Process and device for permeation of biological objects
    10.
    发明授权
    Process and device for permeation of biological objects 失效
    生物体渗透过程和装置

    公开(公告)号：US06542778B1

    公开(公告)日：2003-04-01

    申请号：US09718797

    申请日：2000-11-22

    申请人： Günter Fuhr ,  Ulrich Zimmermann ,  Rolf Hagedorn

    发明人： Günter Fuhr ,  Ulrich Zimmermann ,  Rolf Hagedorn

    IPC分类号： A61N118

    CPC分类号： C12M35/02 ,  A61N1/325

    摘要： A process for treating a biological or synthetic object subjected to an electrical field in a surrounding liquid medium for a predetermined pulse time (t1), the electrical field being formed by at least two electrodes including actuating at least once during the pulse time (t1) each of the electrodes as an anode and as a cathode, to cause at each electrode a polarity reversal and alternating electrolytic increases and reductions in pH of at least a portion of the liquid medium, subjecting the object during the pulse time (t1) to a number of electrical partial pulses which have a frequency in the range of 1 kHz to 1 MHz and which possess partial pulse durations, with sequentially reversing polarity or field direction such that the partial pulses possess sequentially varying partial pulse durations (t11, t12), pulse forms, and/or pulse amplitudes, and selecting the partial pulse durations (t11, t12), pulse forms, and/or pulse amplitudes such that, due to the electrolytic increases and reductions in pH value, substantially equal H+ and OH− ion concentrations are created.

    摘要翻译： 一种用于在预定脉冲时间（t1）下处理在周围液体介质中受到电场的生物或合成物体的过程，所述电场由至少两个电极形成，包括在脉冲时间（t1）期间至少致动一次， 每个电极作为阳极和阴极，在每个电极处引起极性反转和交替电解增加并降低液体介质的至少一部分的pH值，在脉冲时间（t1）期间使物体经受 具有频率在1kHz至1MHz范围内且具有部分脉冲持续时间的电部分脉冲数，具有顺序反转的极性或场方向，使得部分脉冲具有顺序变化的部分脉冲持续时间（t11，t12），脉冲 形式和/或脉冲幅度，以及选择部分脉冲持续时间（t11，t12），脉冲形式和/或脉冲幅度，使得由于电解增加和再次 产生pH值范围内的基本相等的H +和OH-离子浓度。