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39 条记录 (耗时 0.021 秒)

    Method and device for manipulating microparticles in fluid flows
    1.
    发明授权
    Method and device for manipulating microparticles in fluid flows 有权
    用于操纵流体流中微粒的方法和装置

    公开(公告)号：US06727451B1

    公开(公告)日：2004-04-27

    申请号：US09673034

    申请日：2000-11-30

    申请人： Günter Fuhr ,  Rolf Hagedorn ,  Torsten Müller ,  Thomas Schnelle ,  Gabriele Gradl

    发明人： Günter Fuhr ,  Rolf Hagedorn ,  Torsten Müller ,  Thomas Schnelle ,  Gabriele Gradl

    IPC分类号： B01D5702

    CPC分类号： B03C5/026 ,  C12M47/04

    摘要： To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.

    摘要翻译： 为了操纵在与第一通道或多个第一通道相交的流体中的微粒作为流，一个或多个微粒暴露于电场屏障，其将其方向从流动方向朝向流动边缘改变为侧向 （17）。 结果，微粒可以在流动流体之间来回移动。 优选的应用包括处理，分离，分选或限制程序。

    Method for measuring the vitality of cells
    5.
    发明授权
    Method for measuring the vitality of cells 失效
    测量细胞活力的方法

    公开(公告)号：US07501233B2

    公开(公告)日：2009-03-10

    申请号：US10416278

    申请日：2001-11-09

    申请人： Gabriele Gradl ,  Thomas Schnelle ,  Torsten Müller ,  Christoph Reichle

    发明人： Gabriele Gradl ,  Thomas Schnelle ,  Torsten Müller ,  Christoph Reichle

    IPC分类号： C12Q1/00

    CPC分类号： G01N27/447 ,  G01N33/48735

    摘要： A method is described for non-destructive measurement of vitality of biological cells, especially for determination of apoptosis, in which the at least one cell is exposed to high-frequency alternating, especially rotating, electric fields and/or impedance test fields, and at least one rotation measurement, one dielectrophoresis measurement and/or one impedance measurement is performed with the cell for at least one frequency range or individual frequencies, from which at least one measurement parameter is determined that is characteristic of the vitality state of the cell.

    摘要翻译： 描述了一种用于非破坏性测量生物细胞的活力的方法，特别是用于确定细胞凋亡，其中至少一个细胞暴露于高频交替，特别是旋转的电场和/或阻抗测试领域，以及在 对于至少一个频率范围或单独的频率，用该小区执行至少一次旋转测量，一次介电电泳测量和/或一个阻抗测量，从该单元测量至少一个测量参数是该单元的活力状态的特征。

    Method and device for measuring, calibrating and using laser tweezers
    6.
    发明授权
    Method and device for measuring, calibrating and using laser tweezers 失效
    用于测量，校准和使用激光镊子的方法和装置

    公开(公告)号：US06991906B1

    公开(公告)日：2006-01-31

    申请号：US09582609

    申请日：1998-12-21

    申请人： Günter Fuhr ,  Thomas Schnelle ,  Torsten Müller ,  Hermine Hitzler ,  Karl-Otto Greulich ,  Shamoi Monajembashi

    发明人： Günter Fuhr ,  Thomas Schnelle ,  Torsten Müller ,  Hermine Hitzler ,  Karl-Otto Greulich ,  Shamoi Monajembashi

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： H05H3/04 ,  G21K1/006

    摘要： To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical field that has a field gradient which forms an electrical capture area, and the focus is at a distance from the capture are and b) the amplitude of the electrical field, the light power of the light beam forming the optical cage, and/or the distance of the capture area from the focus are varied to detect which varied field property moves the particle from the focus to the capture area or vice versa, or at least to temporarily move the particle into the capture area.

    摘要翻译： 为了在光学保持架的焦点的至少一个颗粒上测量或施加光学诱导的力，采取以下步骤：a）焦点位于具有场梯度的三维电场的微电极布置中， 形成电捕获区域，并且聚焦距离捕获的距离为b）电场的幅度，形成光学笼的光束的光功率和/或捕获区域距离 改变焦点以检测哪个变化的场性质将粒子从焦点移动到捕获区域，反之亦然，或至少临时将颗粒移动到捕获区域中。

    Process and device for the detection of microscopically small objects
    7.
    发明授权
    Process and device for the detection of microscopically small objects 有权
    检测微小物体的过程和设备

    公开(公告)号：US06801311B1

    公开(公告)日：2004-10-05

    申请号：US09889908

    申请日：2001-12-12

    申请人： Günter Fuhr ,  Thomas Schnelle ,  Christoph Reichle ,  Henning Glasser ,  Torsten Müller

    发明人： Günter Fuhr ,  Thomas Schnelle ,  Christoph Reichle ,  Henning Glasser ,  Torsten Müller

    IPC分类号： G01N1502

    CPC分类号： B03C5/028 ,  B03C5/026 ,  G01N15/1031 ,  G01N15/1056 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/105 ,  G01N2015/1075 ,  G01N2015/1415 ,  G01N2015/1447 ,  G01N2015/1495

    摘要： For object detection, particularly in fluidic microsystems, optical imaging of at least one resting or moving object (10) on a structured mask (20) with at least one segment from a flat section (80), in which the object (10) is located at least partially or temporarily and which has a characteristic dimension smaller than the dimension of the object (10) or its movement path, to a detector unit, detection of the quantity of light transmitted by the structured mask (20), and generation of a detector signal which has a predetermined relationship with the quantity of light, and evaluation of the detector signal in regard to the presence of the object (10), its position, its shape and/or the temporal change of the position are performed.

    摘要翻译： 对于物体检测，特别是在流体微系统中，至少一个静止或移动的物体（10）在结构化掩模（20）上的光学成像，其具有来自平坦部分（80）的至少一个部分，其中物体（10） 至少部分地或临时地定位，并且具有比物体（10）或其移动路径的尺寸小的特征尺寸，到检测器单元，由结构化掩模（20）传输的光量的检测，以及 执行与光量具有预定关系的检测器信号，以及关于物体（10）的存在，其位置，形状和/或位置的时间变化的检测器信号的评估。

    METHODS AND DEVICES FOR SEPARATING PARTICLES IN A LIQUID FLOW
    8.
    发明申请
    METHODS AND DEVICES FOR SEPARATING PARTICLES IN A LIQUID FLOW 有权
    用于在液体流中分离颗粒的方法和装置

    公开(公告)号：US20120305398A1

    公开(公告)日：2012-12-06

    申请号：US13586988

    申请日：2012-08-16

    申请人： Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    发明人： Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    IPC分类号： B01D43/00

    CPC分类号： B03C5/005

    摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.

    摘要翻译： 描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）相对于液体沿偏转方向移动 被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒 在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

    Method and device for the convective movement of liquids in microsystems
    9.
    发明授权
    Method and device for the convective movement of liquids in microsystems 失效
    微系统中液体对流运动的方法和装置

    公开(公告)号：US06663757B1

    公开(公告)日：2003-12-16

    申请号：US09868199

    申请日：2001-08-06

    申请人： Günter Führ ,  Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    发明人： Günter Führ ,  Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    IPC分类号： B01L300

    CPC分类号： B01F13/0076 ,  B01F3/1235 ,  B01F13/0077 ,  F15D1/02

    摘要： The aim of the invention is to convectively move at least one liquid in a channel of a microsystem which comprises a predetermined channel direction. To this end, the liquid is, in a partial section of the channel, subjected to an electric field gradient and optionally to a thermal gradient. The gradients are generated in the partial section corresponding to a predetermined field direction, whereby the field direction differs from the channel direction.

    摘要翻译： 本发明的目的是对流地移动包括预定通道方向的微系统的通道中的至少一个液体。 为此，液体在通道的部分部分中经历电场梯度并且任选地经受热梯度。 在对应于预定场方向的部分部分中生成梯度，由此场方向与频道方向不同。

    Methods and devices for separating particles in a liquid flow
    10.
    发明授权
    Methods and devices for separating particles in a liquid flow 有权
    用于分离液体流中的颗粒的方法和装置

    公开(公告)号：US09149813B2

    公开(公告)日：2015-10-06

    申请号：US13586988

    申请日：2012-08-16

    申请人： Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    发明人： Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    IPC分类号： G01N27/447 ,  B03C5/00

    CPC分类号： B03C5/005

    摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.

    摘要翻译： 描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动 被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒 在不同的流动区域（11,12）中发生不同的电，磁或几何特性。