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公开(公告)号：US20090187199A1
公开(公告)日：2009-07-23
申请号：US12340588
申请日：2008-12-19
申请人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微外科技术的小腔。
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公开(公告)号：US08608760B2
公开(公告)日：2013-12-17
申请号：US11962077
申请日：2007-12-20
申请人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微外科技术的小腔。
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公开(公告)号：US08216259B2
公开(公告)日：2012-07-10
申请号：US11766779
申请日：2007-06-21
IPC分类号： A61B17/08
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/04 , A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B17/122 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微外科技术的小腔。
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公开(公告)号：US08197499B2
公开(公告)日：2012-06-12
申请号：US12340588
申请日：2008-12-19
申请人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
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公开(公告)号：US11174460B2
公开(公告)日：2021-11-16
申请号：US14973283
申请日：2015-12-17
摘要： Efficient stem cell delivery into biomaterials using capillary driven encapsulation are disclosed herein where stem/progenitor and/or tissue specific cells are rapidly and efficiently seeded via capillary driven encapsulation into a porous scaffold for cell delivery in the skin or any other organ. The rapid capillary force approach maximizes both seeding time and efficiency by combining hydrophobic, entropic and capillary forces to promote active, ‘bottom-up’ cell engraftment. This methodology uses micro domain patterned biopolymers in a porous dry gel to generate capillary pressure to move a viscous stem cell mix from a hydrophobic reservoir into the polymer matrix to promote active cell seeding within the entire gel volume.
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公开(公告)号：US09636362B2
公开(公告)日：2017-05-02
申请号：US12932736
申请日：2011-03-03
IPC分类号： A61K38/39 , A61K8/73 , A61K35/28 , A61L15/22 , A61L15/40 , A61L15/42 , A61L15/44 , A61L15/60 , A61L27/26 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61K9/70
CPC分类号： A61K35/28 , A61K8/732 , A61K9/7007 , A61K38/39 , A61L15/225 , A61L15/40 , A61L15/425 , A61L15/44 , A61L15/60 , A61L27/26 , A61L27/3804 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/404 , A61L2300/414 , C08L5/00 , C08L89/06
摘要： Compositions and methods are provided for the manufacture and use of a pullulan-based collagen hydrogel film with controlled porosity. The hydrogel is fabricated with salt-induced phase inversion and cross-linking to form a reticular scaffold. This soft collagen scaffold displays excellent handling characteristics, durability, and a porous dermal-like ultrastructure that is maintained in vitro. Cells, including cells involved in tissue repair, are viably sustained within the scaffold. The hydrogel films are biodegradable, and find particular use in wound healing, where the hydrogel scaffold can be replaced by dermal cells over time.
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7.发明授权Threads of Hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof 有权透明质酸和/或其衍生物的丝线，其制造方法及其用途公开(公告)号：US09228027B2
公开(公告)日：2016-01-05
申请号：US13060919
申请日：2009-09-02
IPC分类号： A61K31/728 , A61K9/70 , C08B37/08 , A61L15/28 , A61L17/06 , A61L27/20 , A61L31/04 , C08L5/08
CPC分类号： A61K8/735 , A61K8/0216 , A61K8/027 , A61K8/42 , A61K8/65 , A61K2800/805 , A61L15/28 , A61L17/005 , A61L17/04 , A61L17/06 , A61L17/10 , A61L27/20 , A61L27/54 , A61L31/042 , A61L2300/402 , A61L2430/34 , A61Q19/08 , C08B37/0072 , C08L5/08 , C08L2205/025 , Y10T428/2929
摘要： The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.
摘要翻译： 本发明提供透明质酸和/或其衍生物的丝线，其制备方法及其用途，例如在美学应用（例如真皮填充剂），手术（缝线），药物递送等中。
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公开(公告)号：US20130303480A1
公开(公告)日：2013-11-14
申请号：US13880502
申请日：2011-10-13
IPC分类号： A61L31/04
CPC分类号： A61F2/0059 , A61L15/28 , A61L15/60 , A61L17/04 , A61L17/06 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2430/34 , C08L5/00
摘要： This disclosure relates generally to soft tissue augmentation threads, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.
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公开(公告)号：US20110305745A1
公开(公告)日：2011-12-15
申请号：US12932736
申请日：2011-03-03
CPC分类号： A61K35/28 , A61K8/732 , A61K9/7007 , A61K38/39 , A61L15/225 , A61L15/40 , A61L15/425 , A61L15/44 , A61L15/60 , A61L27/26 , A61L27/3804 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/404 , A61L2300/414 , C08L5/00 , C08L89/06
摘要： Compositions and methods are provided for the manufacture and use of a pullulan-based collagen hydrogel film with controlled porosity. The hydrogel is fabricated with salt-induced phase inversion and cross-linking to form a reticular scaffold. This soft collagen scaffold displays excellent handling characteristics, durability, and a porous dermal-like ultrastructure that is maintained in vitro. Cells, including cells involved in tissue repair, are viably sustained within the scaffold. The hydrogel films are biodegradable, and find particular use in wound healing, where the hydrogel scaffold can be replaced by dermal cells over time.
摘要翻译： 提供组合物和方法用于制造和使用具有受控孔隙率的支链淀粉基胶原蛋白水凝胶膜。 水凝胶用盐诱导的相转化和交联形成网状支架。 这种软胶原蛋白支架显示出优异的处理特性，耐久性和在体外保持的多孔真皮样超微结构。 包括参与组织修复的细胞的细胞在支架内可以持续存在。 水凝胶膜是可生物降解的，并且在伤口愈合中特别有用，其中水凝胶支架可随时间被真皮细胞代替。
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公开(公告)号：US20130142731A1
公开(公告)日：2013-06-06
申请号：US13581902
申请日：2011-01-26
CPC分类号： A61L27/20 , A61B17/06166 , A61B2017/00747 , A61B2017/00893 , A61K8/02 , A61K8/0208 , A61K8/735 , A61K31/728 , A61K47/36 , A61L26/0023 , A61Q19/08 , B29C55/005 , B29K2005/00 , B29K2105/24 , B29L2031/753
摘要： This invention relates generally to threads of hyaluronic acid, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, dermal fillers), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.
摘要翻译： 本发明一般涉及透明质酸的丝线，制造这种丝线的方法及其用途，例如在美学应用（例如面部轮廓，皮肤填充剂），手术（例如缝线），药物递送，负压伤口治疗， 湿润伤口敷料等。
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