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1.发明授权公开(公告)号：US08448702B2
公开(公告)日：2013-05-28
申请号：US13177429
申请日：2011-07-06
申请人： Gerardo Vicente Toledo , Toby Howard Richardson , Ulrich Stingl , Eric J. Mathur , J. Craig Venter
发明人： Gerardo Vicente Toledo , Toby Howard Richardson , Ulrich Stingl , Eric J. Mathur , J. Craig Venter
CPC分类号： E21B43/006 , C09K8/582 , C12N1/20 , C12P5/023 , Y02E50/343
摘要： The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.
摘要翻译： 本发明描述了鉴定含烃地层中甲烷生物生成的兴奋剂的方法。 方法涉及使用微生物核酸序列信息来确定作为将烃转化成甲烷的各种途径中的酶的基因产物。 通过发明方法鉴定的酶和兴奋剂可用于增强生物甲烷生产的方法，例如通过加入煤层和煤层气井。
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2.发明申请公开(公告)号：US20110277991A1
公开(公告)日：2011-11-17
申请号：US13177429
申请日：2011-07-06
申请人： Gerardo Vicente Toledo , Toby Howard Richardson , Ulrich Stingl , Eric J. Mathur , J. Craig Venter
发明人： Gerardo Vicente Toledo , Toby Howard Richardson , Ulrich Stingl , Eric J. Mathur , J. Craig Venter
CPC分类号： E21B43/006 , C09K8/582 , C12N1/20 , C12P5/023 , Y02E50/343
摘要： The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.
摘要翻译： 本发明描述了鉴定含烃地层中甲烷生物生成的兴奋剂的方法。 方法涉及使用微生物核酸序列信息来确定作为将烃转化成甲烷的各种途径中的酶的基因产物。 通过发明方法鉴定的酶和兴奋剂可用于增强生物甲烷生产的方法，例如通过加入煤层和煤层气井。
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3.发明授权公开(公告)号：US07977056B2
公开(公告)日：2011-07-12
申请号：US12464832
申请日：2009-05-12
申请人： Gerardo Vicente Toledo , Toby Howard Richardson , Ulrich Stingl , Eric J. Mathur , J. Craig Venter
发明人： Gerardo Vicente Toledo , Toby Howard Richardson , Ulrich Stingl , Eric J. Mathur , J. Craig Venter
CPC分类号： E21B43/006 , C09K8/582 , C12N1/20 , C12P5/023 , Y02E50/343
摘要： The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.
摘要翻译： 本发明描述了鉴定含烃地层中甲烷生物生成的兴奋剂的方法。 方法涉及使用微生物核酸序列信息来确定作为将烃转化成甲烷的各种途径中的酶的基因产物。 通过发明方法鉴定的酶和兴奋剂可用于增强生物甲烷生产的方法，例如通过加入煤层和煤层气井。
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4.发明授权公开(公告)号：US09556413B2
公开(公告)日：2017-01-31
申请号：US12532403
申请日：2008-03-21
摘要： The invention described below relates to an enclosed cell sorting device and methods of using the device. The device is constructed so that the entire process of cell sorting can be conducted under fully anaerobic conditions to retain viability of anaerobic cells before, during, and after cell sorting. This is accomplished by creating an anaerobic atmosphere for the high speed cell sorter and all its components and by the use of airlocks that allow the introduction of anaerobic containers into the chamber containing the sample.
摘要翻译： 下面描述的本发明涉及封闭的细胞分选装置和使用该装置的方法。 构建该装置使得整个细胞分选过程可以在完全厌氧条件下进行，以在细胞分选之前，期间和之后保留厌氧细胞的活力。 这是通过为高速细胞分选器及其所有组分产生厌氧气氛以及通过使用允许将厌氧容器引入含有样品的室的气闸实现的。
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5.发明申请公开(公告)号：US20100330651A1
公开(公告)日：2010-12-30
申请号：US12532403
申请日：2008-03-21
摘要： The invention described below relates to an enclosed cell sorting device and methods of using the device. The device is constructed so that the entire process of cell sorting can be conducted under fully anaerobic conditions to retain viability of anaerobic cells before, during, and after cell sorting. This is accomplished by creating an anaerobic atmosphere for the high speed cell sorter and all its components and by the use of airlocks that allow the introduction of anaerobic containers into the chamber containing the sample.
摘要翻译： 下面描述的本发明涉及封闭的细胞分选装置和使用该装置的方法。 构建该装置使得整个细胞分选过程可以在完全厌氧条件下进行，以在细胞分选之前，期间和之后保留厌氧细胞的活力。 这是通过为高速细胞分选器及其所有组分产生厌氧气氛以及通过使用允许将厌氧容器引入含有样品的室的气闸实现的。
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公开(公告)号：US09593329B2
公开(公告)日：2017-03-14
申请号：US12247126
申请日：2008-10-07
申请人： Daniel G. Gibson , Lei Young , John I. Glass , Gwynedd A. Benders , J. Craig Venter , Clyde A. Hutchison, III , Hamilton O. Smith
发明人： Daniel G. Gibson , Lei Young , John I. Glass , Gwynedd A. Benders , J. Craig Venter , Clyde A. Hutchison, III , Hamilton O. Smith
CPC分类号： C12N15/1093 , C12N15/81
摘要： A method to assemble any desired nucleic acid molecule by combining cassettes in vitro to form assemblies which are further combined in vivo, or by assembling large numbers of DNA fragments by recombination in a yeast culture to obtain desired DNA molecules of substantial size is described.
摘要翻译： 描述了通过在体外组合盒来组装任何所需核酸分子以形成在体内进一步组合的组装或通过在酵母培养物中通过重组组装大量DNA片段以获得所需的相当大小的DNA分子来组装任何所需核酸分子的方法。
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公开(公告)号：US20120135024A1
公开(公告)日：2012-05-31
申请号：US13070448
申请日：2011-03-23
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20090232820A1
公开(公告)日：2009-09-17
申请号：US12013047
申请日：2008-01-11
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K16/00 , C07H21/04
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。 蛋白质被预测为用于疫苗和/或诊断的有用的抗原。
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公开(公告)号：US09481880B2
公开(公告)日：2016-11-01
申请号：US12598414
申请日：2008-05-01
申请人： John I. Glass , Nina Alperovich , Clyde A. Hutchison, III , Carole Lartigue , Charles E. Merryman , Sanjay Vashee , J. Craig Venter
发明人： John I. Glass , Nina Alperovich , Clyde A. Hutchison, III , Carole Lartigue , Charles E. Merryman , Sanjay Vashee , J. Craig Venter
CPC分类号： C12N15/10 , C12N15/1079 , C12N15/74
摘要： The presently disclosed invention relates to methods of installing a genome isolated from one species (the donor) into suitably prepared cells of a second species (the recipient). Introduction of the donor genetic material into the recipient host cell effectively converts the recipient host cell into a new cell that, as a result of the operation of the donated genetic material, is functionally classified as belonging to the genus and species of the donor genetic material.
摘要翻译： 本公开的本发明涉及将从一个物种（供体）分离的基因组安装到适当制备的第二物种（受体）的细胞中的方法。 将供体遗传物质引入受体宿主细胞有效地将受体宿主细胞转化为新的细胞，由于所捐赠的遗传物质的操作，功能上被归类为供体遗传物质的属和物种 。
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10.发明授权Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof 失效与炎性自身免疫疾病相关的已知基因中的多态性，检测方法及其用途公开(公告)号：US06900016B1
公开(公告)日：2005-05-31
申请号：US09949002
申请日：2001-09-10
申请人： J. Craig Venter , Jinghui N. Zhang , Xiangjun Liu , William Rowe , Anibal Cravchik , Francis Kalush , Ashwinikumar Naik , Gangadharan Subramanian , Trevor Woodage
发明人： J. Craig Venter , Jinghui N. Zhang , Xiangjun Liu , William Rowe , Anibal Cravchik , Francis Kalush , Ashwinikumar Naik , Gangadharan Subramanian , Trevor Woodage
CPC分类号： C12Q1/6883 , C07H21/04 , C12Q2600/156
摘要： The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
摘要翻译： 本发明基于本领域已知的有助于炎症和自身免疫疾病的基因中的新型多态性（SNP）的发现。 这种多态性可导致由变体炎性和自身免疫性疾病相关蛋白介导/调节的多种病症。 本发明提供用于检测和表达变体核酸/蛋白质序列的试剂以及鉴定和使用这些变体的方法。
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