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公开(公告)号：US5847387A
公开(公告)日：1998-12-08
申请号：US711194
申请日：1996-09-10
申请人： Gordon M. Shedd , Kevin J. Owens
发明人： Gordon M. Shedd , Kevin J. Owens
CPC分类号： G01Q30/18 , B82Y35/00 , G01B5/0002 , Y10S977/86
摘要： A support device for a scanned-probe microscope comprises a horizontal base member and a vertical bridge member that are transverse to one another. The horizontal and vertical members are connected at their respective opposite ends by a common chord member extending between the ends. The device preferably includes means for attaching a scanned-probe microscope to a forward surface of the vertical bridge member. The support device preferably further includes one or more bracket members, each attached at one end to the rearward surface of the vertical bridge member and at the opposite end to a rearward surface of the chord member. Each bracket includes a section extending away from the chord member. The horizontal base member and the chord member each has an upper surface substantially coplanar with one another. The substantially coplanar upper surfaces together provide support for a readily separable sample plate. Further in accordance with the invention, a microscope stage assembly comprises the described support device and a readily separable sample plate.
摘要翻译： 用于扫描探针显微镜的支撑装置包括彼此横向的水平基座构件和垂直桥构件。 水平和垂直构件在它们各自的相对端部处通过在端部之间延伸的共同弦构件连接。 该装置优选地包括用于将扫描探针显微镜附接到垂直桥构件的前表面的装置。 支撑装置优选地还包括一个或多个支架构件，每个支架构件的一端连接到垂直桥构件的后表面，并且在与弦构件的后表面相对的一端。 每个支架包括远离弦杆构件的部分。 水平底座构件和弦杆构件各自具有彼此基本共面的上表面。 基本上共面的上表面一起为容易分离的样品板提供支撑。 此外，根据本发明，显微镜台组件包括所描述的支撑装置和容易分离的样品板。
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2.发明申请Reference microplates and methods for making and using the reference microplates 失效参考微孔板和制作和使用参比微孔板的方法公开(公告)号：US20070211245A1
公开(公告)日：2007-09-13
申请号：US11716417
申请日：2007-03-09
IPC分类号： G01N1/10
CPC分类号： G01N21/0332 , B01L3/5085 , B01L3/50851 , B01L2200/148 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/1827 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/31 , G01N35/00594 , G01N35/028 , G01N2001/2893 , G01N2021/0325
摘要： A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.
摘要翻译： 本文描述了参考微孔板，其可用于帮助校准和诊断光学询问系统。 在一个实施方案中，参考微量培养板具有一个具有孔阵列的框架，每个孔包含光学生物传感器，并且每个光学生物传感器至少部分涂覆有物质（例如弹性体，光学环氧树脂）。 在另一个实施方案中，参考微板除了使其光学生物传感器至少部分被物质（例如弹性体，光学环氧树脂）覆盖之外，还具有连接到其上的可控加热装置，其用于加热光学生物传感器。
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公开(公告)号：US6140655A
公开(公告)日：2000-10-31
申请号：US275296
申请日：1999-03-24
IPC分类号： C23F4/00 , H01J37/305 , H01J37/32 , H01L21/302 , H01L21/3065 , H01L21/311 , H01L21/3213 , H01J37/30
CPC分类号： H01L21/31127 , H01J37/3056 , H01L21/3065 , H01L21/31138 , H01L21/32131 , H01J2237/31744
摘要： Water vapor enhanced focused particle beam machining speeds up the removal of polymer-based dielectric materials from areas surrounding metallic interconnects on integrated circuits while at the same time decreasing the rate of removal of aluminum. Selective material removal protects metal interconnects from machining damage and greatly reduces the time that protective material is exposed to the particle beam.
摘要翻译： 水蒸气增强的聚焦粒子束加工加速了从集成电路上的金属互连周围的区域去除基于聚合物的电介质材料，同时降低了铝的去除速率。 选择性材料去除保护金属互连免受加工损伤，并大大减少保护材料暴露于粒子束的时间。
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公开(公告)号：US20100225921A1
公开(公告)日：2010-09-09
申请号：US11521771
申请日：2006-09-15
CPC分类号： G01N35/028 , G01J3/453 , G01N21/0332 , G01N21/553 , G01N21/7743 , G01N2035/00346 , G01N2035/00366
摘要： A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.
摘要翻译： 本文描述了一种筛选装置和方法，其可以自动地处理和询问多个传感器载体（即，多孔板，微孔板），其具有多维布置的，温度补偿的或可温度补偿的光学传感器，同时保持 在对传感器载体进行温度补偿的光学传感器周围相当长的周期内的基本恒定的温度梯度。
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公开(公告)号：US20090247427A1
公开(公告)日：2009-10-01
申请号：US12480886
申请日：2009-06-09
申请人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC分类号： C40B60/12
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译： 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。
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公开(公告)号：US5958799A
公开(公告)日：1999-09-28
申请号：US421811
申请日：1995-04-13
IPC分类号： C23F4/00 , H01J37/305 , H01J37/32 , H01L21/302 , H01L21/3065 , H01L21/311 , H01L21/3213 , H01L21/02
CPC分类号： H01L21/31127 , H01J37/3056 , H01L21/3065 , H01L21/31138 , H01L21/32131 , H01J2237/31744
摘要： Water vapor enhanced focused particle beam machining speeds up the removal of polymer-based dielectric materials from areas surrounding metallic interconnects on integrated circuits while at the same time decreasing the rate of removal of aluminum. Selective material removal protects metal interconnects from machining damage and greatly reduces the time that protective material is exposed to the particle beam.
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7.发明申请公开(公告)号：US20120010105A1
公开(公告)日：2012-01-12
申请号：US13237316
申请日：2011-09-20
申请人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
发明人： Stephen J. Caracci , Volker H.O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译： 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。
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8.发明授权Reference microplates and methods for making and using the reference microplates 失效参考微孔板和制作和使用参比微孔板的方法公开(公告)号：US07674435B2
公开(公告)日：2010-03-09
申请号：US11716417
申请日：2007-03-09
IPC分类号： B01L3/00
CPC分类号： G01N21/0332 , B01L3/5085 , B01L3/50851 , B01L2200/148 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/1827 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/31 , G01N35/00594 , G01N35/028 , G01N2001/2893 , G01N2021/0325
摘要： A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.
摘要翻译： 本文描述了参考微孔板，其可用于帮助校准和诊断光学询问系统。 在一个实施方案中，参考微量培养板具有一个具有孔阵列的框架，每个孔包含光学生物传感器，并且每个光学生物传感器至少部分涂覆有物质（例如弹性体，光学环氧树脂）。 在另一个实施方案中，参考微板除了使其光学生物传感器至少部分被物质（例如弹性体，光学环氧树脂）覆盖之外，还具有连接到其上的可控加热装置，其用于加热光学生物传感器。
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公开(公告)号：US20090027693A1
公开(公告)日：2009-01-29
申请号：US11900315
申请日：2007-09-11
申请人： Michael J. Dailey, JR. , Garrett A. Piech , Gordon M. Shedd , Michael B. Webb , Elvis A. Zambrano
发明人： Michael J. Dailey, JR. , Garrett A. Piech , Gordon M. Shedd , Michael B. Webb , Elvis A. Zambrano
IPC分类号： G01B11/14
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/0636 , G01N35/028
摘要： An optical interrogation system and method are described herein that are capable of detecting and correcting a positional misalignment of a label independent detection (LID) microplate so that the LID microplate can be properly interrogated after being removed from and then re-inserted back into a microplate holder/XY translation stage.
摘要翻译： 本文描述了能够检测和校正标签无关检测（LID）微孔板的位置不对准的光学询问系统和方法，使得LID微孔板在被移除之后被重新插入微孔板之后被适当询问 持有人/ XY翻译阶段。
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10.发明授权Optical reader system and method that uses non-coherent illumination and angular filtering to interrogate a label independent biosensor 有权光学读取器系统和方法，其使用非相干照明和角度滤波来询问标签独立的生物传感器公开(公告)号：US07454094B2
公开(公告)日：2008-11-18
申请号：US11213654
申请日：2005-08-26
申请人： Jacques Gollier , Gordon M. Shedd
发明人： Jacques Gollier , Gordon M. Shedd
CPC分类号： G01N21/7743
摘要： An optical reader system and method are described herein that directs a non-coherent light towards a biosensor, collects the non-coherent light which is reflected (or transmitted) from (or through) the biosensor, and then angularly filters the collected non-coherent light to obtain a narrow spectral response which can be analyzed to determine if a biological substance is located on the biosensor or if a biomolecular event took place on the biosensor.
摘要翻译： 这里描述了一种光学读取器系统和方法，其将非相干光引向生物传感器，收集从（或通过）生物传感器反射（或传输）的非相干光，然后对所收集的非相干 光以获得可以被分析以确定生物物质是位于生物传感器上还是在生物传感器上发生生物分子事件的窄光谱响应。
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