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1.发明申请NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE 审中-公开具有不同发布速度的NANOCARRIERS POSSESSING组件公开(公告)号：US20100303850A1
公开(公告)日：2010-12-02
申请号：US12788261
申请日：2010-05-26
申请人： Grayson B. Lipford , Charles Zepp , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Llyod Johnston
发明人： Grayson B. Lipford , Charles Zepp , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Llyod Johnston
IPC分类号： A61K39/385 , A61P37/02 , A61P31/00 , A61P35/00 , A61P3/00
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.
摘要翻译： 本发明涉及包含免疫调节剂和从合成纳米载体差异释放的抗原的合成纳米载体的组合物和相关方法。
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公开(公告)号：US08629151B2
公开(公告)日：2014-01-14
申请号：US12788266
申请日：2010-05-26
申请人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
发明人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
IPC分类号： A01N43/90
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译： 本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。 缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。
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3.发明申请SYNTHETIC VIRUS-LIKE PARTICLES CONJUGATED TO HUMAN PAPILLOMAVIRUS CAPSID PEPTIDES FOR USE AS VACCINES 审中-公开合成病毒颗粒与人类斑马鱼胶囊一起用作疫苗公开(公告)号：US20110171248A1
公开(公告)日：2011-07-14
申请号：US12986874
申请日：2011-01-07
IPC分类号： A61K39/385 , C07K17/00 , A61K38/16 , C07K14/00 , C07K14/025 , A61P31/12 , A61P37/04 , C12N7/00
CPC分类号： A61K39/12 , A61K39/385 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/6935 , A61K2039/5258 , A61K2039/6093 , A61K2039/62 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , G01N33/54346
摘要： Disclosed are compositions and related methods that involve a synthetic nanocarrier that includes at least one peptide obtained from Human papillomavirus L1 or L2 capsid protein; wherein the peptide is coupled to an external surface of the synthetic nanocarrier.
摘要翻译： 公开了涉及包含从人乳头瘤病毒L1或L2衣壳蛋白获得的至少一种肽的合成纳米载体的组合物和相关方法; 其中所述肽与所述合成纳米载体的外表面偶联。
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公开(公告)号：US20110293723A1
公开(公告)日：2011-12-01
申请号：US13116556
申请日：2011-05-26
IPC分类号： A61K9/14 , A61K39/385 , A61K39/12 , A61K39/10 , A61K39/145 , A61K39/29 , A61K39/25 , A61K39/165 , A61K39/20 , A61K39/09 , A61K39/13 , A61K39/205 , A61K39/15 , A61K39/285 , A61K39/235 , A61K39/125 , A61K39/155 , A61K39/106 , A61K39/118 , A61K39/08 , A61K39/05 , A61K39/108 , A61K39/04 , A61K39/095 , A61K39/104 , A61K39/112 , A61K39/085 , A61P35/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20 , A61P31/22 , A61K38/21 , A61K39/00 , B82Y5/00
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are not coupled to the synthetic nanocarriers, and a pharmaceutically acceptable excipient.
摘要翻译： 公开了剂型和相关方法，其包括具有一个或多个与其偶联的第一抗原的第一批合成纳米载体，一种或多种不与合成纳米载体偶联的第二抗原和药学上可接受的赋形剂。
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公开(公告)号：US20120027806A1
公开(公告)日：2012-02-02
申请号：US13116542
申请日：2011-05-26
申请人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
发明人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K9/14 , A61K39/39 , A61P35/00 , A61P31/00 , A61P25/28 , A61P25/30 , A61P17/00 , A61P11/06 , A61P11/00 , A61K39/00 , A61P3/00 , B82Y5/00
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/403 , Y02A50/466 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
摘要翻译： 公开了具有偶联佐剂组合物的合成纳米载体组合物以及相关方法。
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公开(公告)号：US20110293701A1
公开(公告)日：2011-12-01
申请号：US13116488
申请日：2011-05-26
IPC分类号： A61K9/127 , A61K39/116 , A61K39/00 , A61K38/21 , A61P31/00 , A61P35/00 , A61P25/30 , A61K39/295 , A61K9/14
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： The invention relates, at least in part, to compositions comprising populations of synthetic nanocarriers that comprise different sets of antigens as well as related methods.
摘要翻译： 本发明至少部分涉及包含包含不同组抗原的合成纳米载体群以及相关方法的组合物。
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公开(公告)号：US20110293700A1
公开(公告)日：2011-12-01
申请号：US13116453
申请日：2011-05-26
IPC分类号： A61K9/127 , A61K47/30 , A61K47/42 , A61K39/385 , A61P29/00 , A61K9/14 , A61P35/00 , A61P31/00 , A61P17/00 , A61P11/06 , A61P11/00 , A61K39/00 , A61P37/00
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with separate adjuvant compositions as well as related methods.
摘要翻译： 公开了具有单独的佐剂组合物的合成纳米载体组合物以及相关方法。
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公开(公告)号：US20180043023A1
公开(公告)日：2018-02-15
申请号：US15684896
申请日：2017-08-23
申请人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
发明人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K45/06 , A61K9/51 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K47/22 , A61K47/02 , A61K39/39 , A61K39/35 , A61K39/00 , A61K39/385 , A61K47/24
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
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公开(公告)号：US09066978B2
公开(公告)日：2015-06-30
申请号：US13116542
申请日：2011-05-26
申请人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
发明人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K9/00 , A61K45/00 , A61K47/06 , A61K39/00 , A61K39/38 , A61K45/06 , A61K9/51 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/48
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/403 , Y02A50/466 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
摘要翻译： 公开了具有偶联佐剂组合物的合成纳米载体组合物以及相关方法。
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公开(公告)号：US07410975B2
公开(公告)日：2008-08-12
申请号：US10872196
申请日：2004-06-18
IPC分类号： A61K31/517 , C07D239/72 , C07D239/93 , C07D239/94
CPC分类号： A61K31/437 , A61K31/122 , A61K31/382 , A61K31/4462 , A61K31/4709 , A61K31/496 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/553 , C07D221/10 , C07D239/94 , C07D239/95 , C07D405/12
摘要： The invention provides methods and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a small molecule having a core structure including at least two rings. Certain of the compounds are 4-primary amino quinolines. Many of the compounds and methods are useful specifically for inhibiting immune stimulation involving at least one of TLR9, TLR8, TLR7, and TLR3. The methods may have use in the treatment of autoimmunity, inflammation, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.
摘要翻译： 本发明提供了用于通过Toll样受体调节信号传导的方法和组合物。 所述方法包括使TLR表达细胞与具有包含至少两个环的核心结构的小分子接触。 某些化合物是4-伯氨基喹啉。 许多化合物和方法专门用于抑制涉及TLR9，TLR8，TLR7和TLR3中的至少一种的免疫刺激。 该方法可用于治疗自身免疫，炎症，过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。
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