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    Spray drying apparatus and methods of use
    4.
    发明授权
    Spray drying apparatus and methods of use 有权
    喷雾干燥装置及使用方法

    公开(公告)号：US06560897B2

    公开(公告)日：2003-05-13

    申请号：US10045419

    申请日：2001-10-26

    申请人： Donald E. Chickering, III ,  Mark J. Keegan ,  Greg Randall ,  Howard Bernstein ,  Julie Straub

    发明人： Donald E. Chickering, III ,  Mark J. Keegan ,  Greg Randall ,  Howard Bernstein ,  Julie Straub

    IPC分类号： F26B1700

    CPC分类号： B01J2/04 ,  B01D1/18

    摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. Te secondary drying apparatus can include multiple secondary apparati, which are independently controlled for temperature and/or have different dimensions (cross-sectional areas and/or lengths), to allow for optimization of drying conditions. For example, in one embodiment, the temperatures of the secondary appararati are set to gradually increase, or decrease, enabling the particles to be dried at multiple temperatures and drying conditions. In another embodiment, the apparati have different dimensions to alter the velocity at which the particles are dried, to accommodate changes in particle aggregation or other properties affecting product yield. A preferred application for the spray drying process and equipment is in the production of microparticles, between about 1 and 200 &mgr;m in diameter, which can be used to deliver therapeutic and diagnostic agents.

    摘要翻译： 已经开发了改进的喷雾干燥装置及其使用方法。 喷雾干燥设备包括初级干燥室和次级干燥设备，其包括具有足以增加干燥气体和液滴/颗粒之间的接触时间的长度的管道，以将干燥颗粒以期望的程度以干燥速率和温度 这不足以在没有二次干燥装置的情况下提供足够的干燥。 二次干燥装置提高喷雾干燥器系统的干燥效率，而不增加干燥速率，同时最小化产率损失。 Te二次干燥装置可以包括多个二次装置，其独立地控制温度和/或具有不同的尺寸（横截面积和/或长度），以允许优化干燥条件。 例如，在一个实施方案中，二次装置的温度被设定为逐渐增加或降低，使颗粒能够在多个温度和干燥条件下干燥。 在另一个实施方案中，所述装置具有不同的尺寸以改变颗粒干燥的速度，以适应颗粒聚集的变化或影响产品产率的其它性质。 用于喷雾干燥方法和设备的优选应用是生产直径约1-200μm的微粒，其可用于递送治疗和诊断剂。

    Spray drying method
    6.
    发明授权
    Spray drying method 有权
    喷雾干燥法

    公开(公告)号：US06308434B1

    公开(公告)日：2001-10-30

    申请号：US09756950

    申请日：2001-01-09

    申请人： Donald E. Chickering, III ,  Mark J. Keegan ,  Greg Randall ,  Howard Bernstein ,  Julie Straub

    发明人： Donald E. Chickering, III ,  Mark J. Keegan ,  Greg Randall ,  Howard Bernstein ,  Julie Straub

    IPC分类号： F26B308

    CPC分类号： B01J2/04 ,  B01D1/18

    摘要： Improved spray drying methods of have been developed. The spray drying method includes use of a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of microparticles, between about 1 and 200 &mgr;m in diameter, which can be used to deliver therapeutic and diagnostic agents.

    摘要翻译： 已经开发出改进的喷雾干燥方法。 喷雾干燥方法包括使用初级干燥室和二次干燥设备，其包括具有足以增加干燥气体和液滴/颗粒之间的接触时间的长度的管道，以将颗粒干燥至所需的程度，干燥速率 温度太低，无法在没有二次干燥装置的情况下提供足够的干燥。 二次干燥装置提高喷雾干燥器系统的干燥效率，而不增加干燥速率，同时最小化产率损失。 管道长度与初级干燥室长度之比至少为2：1。 管道直径基本上小于初级干燥室的直径，使得颗粒以更高的速度移动通过管道以最小化产品损失。 初级干燥室的横截面积与管道的横截面面积的比率最优选为约16:1。 管道优选地处于紧凑的线圈设计中，其可以更容易地被输送并且具有最小的空间要求，并且可以可选地包括用于控制二次干燥过程的温度的护套。 用于喷雾干燥方法和设备的优选应用是生产直径约1-200μm的微粒，其可用于递送治疗和诊断剂。