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1.发明申请NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE 审中-公开具有不同发布速度的NANOCARRIERS POSSESSING组件公开(公告)号：US20100303850A1
公开(公告)日：2010-12-02
申请号：US12788261
申请日：2010-05-26
申请人： Grayson B. Lipford , Charles Zepp , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Llyod Johnston
发明人： Grayson B. Lipford , Charles Zepp , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Llyod Johnston
IPC分类号： A61K39/385 , A61P37/02 , A61P31/00 , A61P35/00 , A61P3/00
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.
摘要翻译： 本发明涉及包含免疫调节剂和从合成纳米载体差异释放的抗原的合成纳米载体的组合物和相关方法。
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公开(公告)号：US08629151B2
公开(公告)日：2014-01-14
申请号：US12788266
申请日：2010-05-26
申请人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
发明人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
IPC分类号： A01N43/90
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译： 本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。 缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。
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3.发明申请TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS 审中-公开具有敏感性释放免疫调节剂的靶向合成纳米颗粒公开(公告)号：US20110020388A1
公开(公告)日：2011-01-27
申请号：US12788260
申请日：2010-05-26
申请人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
发明人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
IPC分类号： A61K39/385 , C07D471/04 , C07D473/34 , C07H21/00 , A61P37/02
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译： 本发明涉及靶细胞中诸如抗原呈递细胞（APC）的作用位点的合成纳米载体的组合物和相关方法，并且包含以pH敏感方式从合成纳米载体解离的免疫调节剂。 还公开了与合成纳米载体相关的组合物和方法，其包封以pH敏感方式从合成纳米载体解离的不稳定免疫调节剂。
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公开(公告)号：US20100316714A1
公开(公告)日：2010-12-16
申请号：US12637723
申请日：2009-12-14
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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5.发明申请Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods 审中-公开组织样本中复杂肽混合物的有效定量和改进的治疗方法公开(公告)号：US20090275496A1
公开(公告)日：2009-11-05
申请号：US12316297
申请日：2008-12-10
申请人： Sam Baldwin , Dustan Bonnin , Keith Johnson , Jeff Krieger , James Rasmussen , Bei Yu , Eric Zanelli , Jianxin Zhang , Kathryn H. Collins , Michelle Genova , Joseph Kovalchin
发明人： Sam Baldwin , Dustan Bonnin , Keith Johnson , Jeff Krieger , James Rasmussen , Bei Yu , Eric Zanelli , Jianxin Zhang , Kathryn H. Collins , Michelle Genova , Joseph Kovalchin
CPC分类号： A61K31/785 , A61K9/0019 , A61K38/07 , A61K38/16 , C07K5/101 , C07K5/1016 , G01N33/564 , G01N33/6842
摘要： The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex peptide mixtures. The instant invention further provides methods for administering complex peptide mixtures to a subject in need thereof, the dosage regimen and quantity determined based on the above mentioned method for detection and quantitation.
摘要翻译： 本发明提供了检测和定量组织样品中复合肽混合物的方法以及这种复合肽混合物施用结果的功能性读出方法。 本发明还提供了向有需要的受试者施用复合肽混合物的方法，基于上述检测和定量方法确定的剂量方案和量。
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公开(公告)号：US20050147597A1
公开(公告)日：2005-07-07
申请号：US11069166
申请日：2005-02-28
申请人： Takafumi Ueno , Toyoaki Murohara , Keith Robinson , Nicolas Chronos , Sam Baldwin , Maria Palasis
发明人： Takafumi Ueno , Toyoaki Murohara , Keith Robinson , Nicolas Chronos , Sam Baldwin , Maria Palasis
IPC分类号： A61K48/00 , A61K35/12 , A61K35/28 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/46 , A61P9/00 , C12N5/074 , C12N5/0775 , A61K45/00
CPC分类号： A61K35/28 , A61K48/00 , A61K2035/124 , C12N5/0663 , C12N5/0692 , C12N2500/84 , C12N2501/58 , C12N2501/91 , C12N2506/1353
摘要： This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of increasing angiogenesis in diseased tissue in a subject, which methods comprise: a) isolating autologous bone marrow-mononuclear cells from the subject; and b) transplanting locally into the diseased or damaged tissue an effective amount of the autologous bone-marrow mononuclear cells, thereby forming new blood vessels in the diseased or damaged tissue. The new blood vessels may be capillaries or collateral vessels in ischemic tissue or any site of angiogenesis. Also provided are methods of treating tissue in disease or injury by local transplantation with an effective amount of the autologous bone marrow-mononuclear cells so as to induce vascularization in such diseased tissue.
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7.发明授权Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue 有权通过骨髓来源的细胞移植在心肌缺血组织和骨骼肌缺血组织中的治疗性血管发生公开(公告)号：US07799349B2
公开(公告)日：2010-09-21
申请号：US11069166
申请日：2005-02-28
申请人： Takafumi Ueno , Toyoaki Murohara , Keith Allen Robinson , Nicolas A. F. Chronos , Sam Baldwin , Maria Palasis
发明人： Takafumi Ueno , Toyoaki Murohara , Keith Allen Robinson , Nicolas A. F. Chronos , Sam Baldwin , Maria Palasis
CPC分类号： A61K35/28 , A61K48/00 , A61K2035/124 , C12N5/0663 , C12N5/0692 , C12N2500/84 , C12N2501/58 , C12N2501/91 , C12N2506/1353
摘要： This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of increasing angiogenesis in diseased tissue in a subject, which methods comprise: a) isolating autologous bone marrow-mononuclear cells from the subject; and b) transplanting locally into the diseased or damaged tissue an effective amount of the autologous bone-marrow mononuclear cells, thereby forming new blood vessels in the diseased or damaged tissue. The new blood vessels may be capillaries or collateral vessels in ischemic tissue or any site of angiogenesis. Also provided are methods of treating tissue in disease or injury by local transplantation with an effective amount of the autologous bone marrow-mononuclear cells so as to induce vascularization in such diseased tissue.
摘要翻译： 本发明提供了在受试者的患病或受损组织中形成新血管的方法，增加受试者中患病或受损组织的血流量的方法，以及增加受试者患病组织中血管生成的方法，所述方法包括：a） 从受试者中分离自体骨髓单核细胞; 和b）将有效量的自体骨髓单核细胞局部移植到患病或受损组织中，从而在患病或受损组织中形成新的血管。 新血管可能是缺血组织中的毛细血管或侧支血管或任何血管发生部位。 还提供了通过局部移植用有效量的自体骨髓单核细胞治疗疾病或损伤组织以便在这种患病组织中诱导血管形成的方法。
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公开(公告)号：US07655221B2
公开(公告)日：2010-02-02
申请号：US11283406
申请日：2005-11-17
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20140249089A1
公开(公告)日：2014-09-04
申请号：US14169672
申请日：2014-01-31
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zannelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zannelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
IPC分类号： C07K14/435
CPC分类号： C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US08475779B2
公开(公告)日：2013-07-02
申请号：US12637723
申请日：2009-12-14
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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