-
1.发明申请NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE 审中-公开具有不同发布速度的NANOCARRIERS POSSESSING组件公开(公告)号：US20100303850A1
公开(公告)日：2010-12-02
申请号：US12788261
申请日：2010-05-26
申请人： Grayson B. Lipford , Charles Zepp , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Llyod Johnston
发明人： Grayson B. Lipford , Charles Zepp , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Llyod Johnston
IPC分类号： A61K39/385 , A61P37/02 , A61P31/00 , A61P35/00 , A61P3/00
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.
摘要翻译： 本发明涉及包含免疫调节剂和从合成纳米载体差异释放的抗原的合成纳米载体的组合物和相关方法。
-
公开(公告)号：US08629151B2
公开(公告)日：2014-01-14
申请号：US12788266
申请日：2010-05-26
申请人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
发明人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
IPC分类号： A01N43/90
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译： 本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。 缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。
-
3.发明申请TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS 审中-公开具有敏感性释放免疫调节剂的靶向合成纳米颗粒公开(公告)号：US20110020388A1
公开(公告)日：2011-01-27
申请号：US12788260
申请日：2010-05-26
申请人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
发明人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
IPC分类号： A61K39/385 , C07D471/04 , C07D473/34 , C07H21/00 , A61P37/02
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译： 本发明涉及靶细胞中诸如抗原呈递细胞（APC）的作用位点的合成纳米载体的组合物和相关方法，并且包含以pH敏感方式从合成纳米载体解离的免疫调节剂。 还公开了与合成纳米载体相关的组合物和方法，其包封以pH敏感方式从合成纳米载体解离的不稳定免疫调节剂。
-
4.发明申请SYNTHETIC NANOCARRIER VACCINES COMPRISING PEPTIDES OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS HEMAGGLUTININ 审中-公开包含从人类流感病毒血清白蛋白获得或衍生的肽的合成纳米颗粒疫苗公开(公告)号：US20120064110A1
公开(公告)日：2012-03-15
申请号：US13213496
申请日：2011-08-19
申请人： Petr Ilyinskii , Yun Gao , Fen-ni Fu , Grayson B. Lipford
发明人： Petr Ilyinskii , Yun Gao , Fen-ni Fu , Grayson B. Lipford
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093 , C12N2760/16134 , Y10T428/2982
摘要： This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human influenza A virus hemagglutinin.
摘要翻译： 本发明涉及可用于免疫受试者免受流感的组合物和方法。 通常，组合物和方法包括获自或源自人甲型流感病毒血凝素的肽。
-
5.发明申请SYNTHETIC VIRUS-LIKE PARTICLES CONJUGATED TO HUMAN PAPILLOMAVIRUS CAPSID PEPTIDES FOR USE AS VACCINES 审中-公开合成病毒颗粒与人类斑马鱼胶囊一起用作疫苗公开(公告)号：US20110171248A1
公开(公告)日：2011-07-14
申请号：US12986874
申请日：2011-01-07
IPC分类号： A61K39/385 , C07K17/00 , A61K38/16 , C07K14/00 , C07K14/025 , A61P31/12 , A61P37/04 , C12N7/00
CPC分类号： A61K39/12 , A61K39/385 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/6935 , A61K2039/5258 , A61K2039/6093 , A61K2039/62 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , G01N33/54346
摘要： Disclosed are compositions and related methods that involve a synthetic nanocarrier that includes at least one peptide obtained from Human papillomavirus L1 or L2 capsid protein; wherein the peptide is coupled to an external surface of the synthetic nanocarrier.
摘要翻译： 公开了涉及包含从人乳头瘤病毒L1或L2衣壳蛋白获得的至少一种肽的合成纳米载体的组合物和相关方法; 其中所述肽与所述合成纳米载体的外表面偶联。
-
6.发明申请SYNTHETIC NANOCARRIER VACCINES COMPRISING PEPTIDES OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS M2E 审中-公开包含从人类流感病毒M2E获得或衍生的肽的合成纳米抗体疫苗公开(公告)号：US20120058154A1
公开(公告)日：2012-03-08
申请号：US13213552
申请日：2011-08-19
申请人： Petr Ilyinskii , Yun Gao , Grayson B. Lipford
发明人： Petr Ilyinskii , Yun Gao , Grayson B. Lipford
IPC分类号： A61K39/385 , C07K17/02 , C07K17/14 , C07K17/08 , A61K39/145 , A61P37/04 , A61P31/16 , C08G63/91 , C07K17/00 , C07K14/11 , B82Y5/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093 , C12N2760/16134 , Y10T428/2982
摘要： This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human influenza A virus M2 protein.
摘要翻译： 本发明涉及可用于免疫受试者免受流感的组合物和方法。 通常，组合物和方法包括获自或源自人流感病毒M2蛋白的肽。
-
7.发明申请SYNTHETIC NANOCARRIER VACCINES COMPRISING PROTEINS OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS HEMAGGLUTININ 审中-公开包含从人类流感病毒获得或衍生的蛋白质的合成纳米抗体疫苗公开(公告)号：US20120058153A1
公开(公告)日：2012-03-08
申请号：US13213529
申请日：2011-08-19
申请人： Petr Ilyinskii , Yun Gao , Grayson B. Lipford
发明人： Petr Ilyinskii , Yun Gao , Grayson B. Lipford
IPC分类号： A61K39/385 , A61K9/14 , A61P31/16 , A61P37/04 , C07K14/11 , C08G65/333 , B82Y40/00 , B82Y5/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093 , C12N2760/16134 , Y10T428/2982
摘要： This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include polypeptides obtained or derived from human influenza A virus hemagglutinin.
摘要翻译： 本发明涉及可用于免疫受试者免受流感的组合物和方法。 通常，组合物和方法包括获自或源自人流感病毒血凝素的多肽。
-
公开(公告)号：US09994443B2
公开(公告)日：2018-06-12
申请号：US13289211
申请日：2011-11-04
申请人： Charles Zepp , Yun Gao
发明人： Charles Zepp , Yun Gao
IPC分类号： B82Y5/00 , C07D401/04 , C08G73/02 , C08G65/26 , C08G65/329 , C08G65/333 , A61K39/00 , A61K39/385 , A61K47/60 , A61K47/59
CPC分类号： B82Y5/00 , A61K39/0013 , A61K39/385 , A61K47/59 , A61K47/60 , C07D401/04 , C08G65/2609 , C08G65/2618 , C08G65/329 , C08G65/33317 , C08G65/33396 , C08G73/0206 , C08G73/0233 , C08L2203/02
摘要： Provided herein are compounds and related composition and methods that may be used to raise an antibody response to nicotinic compounds, in some embodiments.
-
9.发明申请SYNTHETIC NANOCARRIERS WITH REACTIVE GROUPS THAT RELEASE BIOLOGICALLY ACTIVE AGENTS 审中-公开具有生物活性剂的反应性组合物的合成纳米颗粒公开(公告)号：US20120171229A1
公开(公告)日：2012-07-05
申请号：US13341020
申请日：2011-12-30
申请人： Charles Zepp , Yun Gao
发明人： Charles Zepp , Yun Gao
IPC分类号： A61K47/48 , C07H23/00 , A61K39/00 , A61P37/02 , A61P31/12 , C08G63/08 , B32B15/02 , C07K17/02 , A61P35/00 , B82Y5/00 , B82Y30/00
CPC分类号： C08G63/912 , A61K39/39 , A61K47/593 , A61K47/6923 , A61K47/6929 , B82Y5/00 , B82Y40/00 , C07H15/252 , C08G63/08 , C12N2770/32023 , Y10T428/2989
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of synthetic nanocarriers, or components thereof, and biologically active agents, such as immunomodulatory agents, antigens, anticancer agents or antiviral agents. The biologically active agents are released from the synthetic nanocarriers in the presence of a reducing agent or by reaction with a thiol.
摘要翻译： 本发明涉及合成纳米载体或其组分的缀合物和生物活性剂如免疫调节剂，抗原，抗癌剂或抗病毒剂的组合物及相关化合物和方法。 生物活性剂在还原剂存在下或通过与硫醇反应从合成纳米载体中释放出来。
-
公开(公告)号：US20120114677A1
公开(公告)日：2012-05-10
申请号：US13289211
申请日：2011-11-04
申请人： Charles Zepp , Yun Gao
发明人： Charles Zepp , Yun Gao
CPC分类号： B82Y5/00 , A61K39/0013 , A61K39/385 , A61K47/59 , A61K47/60 , C07D401/04 , C08G65/2609 , C08G65/2618 , C08G65/329 , C08G65/33317 , C08G65/33396 , C08G73/0206 , C08G73/0233 , C08L2203/02
摘要： Provided herein are compounds and related composition and methods that may be used to raise an antibody response to nicotinic compounds, in some embodiments.
摘要翻译： 在一些实施方案中，本文提供可用于提高对烟碱化合物的抗体应答的化合物和相关组合物和方法。
-
-
-
-
-
-
-
-
-
搜索结果
75 条记录 (耗时 0.04 秒)
