利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

157 条记录 (耗时 0.052 秒)

    Cloning of the gene which codes for the pilinic subunit fim3 of Bordetella pertussis
    3.
    发明授权
    Cloning of the gene which codes for the pilinic subunit fim3 of Bordetella pertussis 失效
    克隆编码百日咳百日咳杆菌的pilinic亚基fim3的基因

    公开(公告)号：US5525489A

    公开(公告)日：1996-06-11

    申请号：US29952

    申请日：1993-03-09

    申请人： Anna Cuzzoni ,  Barbara Riboli ,  Paola Pedroni ,  Francesca De Ferra ,  Guido Grandi

    发明人： Anna Cuzzoni ,  Barbara Riboli ,  Paola Pedroni ,  Francesca De Ferra ,  Guido Grandi

    IPC分类号： A61K39/00 ,  C07K14/235 ,  C12N15/31 ,  C07H21/02 ,  A61K39/10 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/235 ,  A61K39/00

    摘要： A cloned DNA fragment of Bordetella pertussis including the gene which codes for the pilinic subunit fim3, vectors which contain it and microorganisms transformed by the vectors.The protein and peptides corresponding to at least one epitope of the gene which codes for the pilinic subunit fim3 are particularly useful for the development of acellular anti-pertussis vaccines.In addition, a strain of Bordetella modified by a recombinant replication or genome-integration vector containing the cloned DNA fragment or the gene or a fraction thereof is particularly suitable for the development of a cellular anti-pertussis vaccine.

    摘要翻译： 百日咳博德特氏菌的克隆DNA片段，包括编码pilinic亚基fim3的基因，含有载体的载体和载体转化的微生物。 对应于编码pilinic亚基fim3的基因的至少一个表位的蛋白质和肽特别可用于开发无细胞抗百日咳疫苗。 此外，通过含有克隆的DNA片段或其基因或其部分的重组复制或基因组整合载体修饰的博德特氏菌菌株特别适用于细胞抗百日咳疫苗的开发。

    Immunogenic bacterial vesicles with outer membrane proteins
    8.
    发明授权
    Immunogenic bacterial vesicles with outer membrane proteins 有权
    具有外膜蛋白的免疫原性细胞囊泡

    公开(公告)号：US09206399B2

    公开(公告)日：2015-12-08

    申请号：US11666786

    申请日：2005-10-28

    申请人： Jeannette Adu-Bobie ,  Mariagrazia Pizza ,  Nathalie Norais ,  Germano Ferrari ,  Guido Grandi

    发明人： Jeannette Adu-Bobie ,  Mariagrazia Pizza ,  Nathalie Norais ,  Germano Ferrari ,  Guido Grandi

    IPC分类号： A61K39/095 ,  C12N9/10 ,  A61K39/108

    CPC分类号： C07K14/245 ,  A61K39/00 ,  A61K39/0258 ,  A61K39/095 ,  C07K14/22 ,  C12N9/1051 ,  Y02A50/474

    摘要： Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.

    摘要翻译： 脑膜炎球菌mltA同系物的敲除使细菌自发释放富含免疫原性外膜蛋白的囊泡，并且能够以比正常生产过程制备的OMV更高的杀菌滴度引发交叉保护性抗体应答。 因此，本发明提供了具有其mltA基因的敲除突变的细菌。 本发明还提供了一种细菌，其中所述细菌：（i）具有包含肽聚糖的细胞壁; 和（ii）不表达具有MltA蛋白的裂解转糖苷酶活性的蛋白质。 本发明还提供包含囊泡的组合物，其在本发明的细菌培养期间释放到培养基中。

    Neisserial antigenic peptides
    9.
    发明授权
    Neisserial antigenic peptides 有权
    Neisserial抗原肽

    公开(公告)号：US09067987B2

    公开(公告)日：2015-06-30

    申请号：US13405213

    申请日：2012-02-24

    申请人： Cesira Galeotti ,  Guido Grandi ,  Vega Masignani ,  Marirosa Mora ,  Mariagrazia Pizza ,  Rino Rappuoli ,  Guilio Ratti ,  Vincenzo Scarlato ,  Maria Scarselli

    发明人： Cesira Galeotti ,  Guido Grandi ,  Vega Masignani ,  Marirosa Mora ,  Mariagrazia Pizza ,  Rino Rappuoli ,  Guilio Ratti ,  Vincenzo Scarlato ,  Maria Scarselli

    IPC分类号： C07K14/22 ,  A61K39/095 ,  A61K39/00 ,  A61K48/00

    CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/55505 ,  C07K14/22

    摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

    摘要翻译： 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如， 反义核酸）。 另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。 本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。 本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。