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公开(公告)号：US5744097A
公开(公告)日：1998-04-28
申请号：US621888
申请日：1996-03-26
IPC分类号： G01N21/64 , C07H21/04 , C12M1/00 , C12Q1/68 , G01N27/447 , G01N33/50 , G01N15/06 , C12N15/00 , G01N33/00
CPC分类号： G01N27/44743 , Y10T436/143333
摘要： The improved DNA base sequencer comprising an electrophoresis plate having a gel electrolyte layer held between two glass plates, one of which is partially cut away on the top edge in the direction of width, an assay compartment for accommodating said electrophoresis plate in a vertically erect position, a lower reservoir of a buffer solution in which the lower part of the gel electrolyte layer in the electrophoresis plate is to be immersed, an upper reservoir of a buffer solution in which the upper part of said electrolyte layer is to be immersed, photoexciting laser light applying means by which laser light is emitted from a lateral side of the electrophoresis plate in such a way that it crosses the lanes in said plate at right angles, and fluorescence detecting means by which the fluorescence emitted from a DNA fragment illuminated with the laser light is picked up and converted to an electric signal, and the apparatus is characterized in that a sharkstoothcomb made of a water-swellable material is inserted from the top edge of said electrophoresis plate into the space between the two glass plates, either the top or bottom edge of said sharkstoothcomb being provided with a plurality of teeth which are each tapered from the root toward the tip. Using this apparatus, samples can be easily and yet positively injected at specified lane positions on the gel electrolyte layer.
摘要翻译： 改进的DNA碱基测序仪包括电泳板，该电泳板具有保持在两个玻璃板之间的凝胶电解质层，其中一个玻璃板在宽度方向上的顶部边缘部分地被切除;测定室，用于将所述电泳板容纳在垂直竖立位置 将要浸渍电泳板中的凝胶电解质层的下部的缓冲溶液的下部储存器，要浸渍所述电解质层的上部的缓冲溶液的上部储存器，光激发 光照射装置，其从电泳板的侧面以这样的方式从激光垂直方向穿过所述板中的通道;以及荧光检测装置，从激光照射的DNA片段发出的荧光 光拾取并转换为电信号，该装置的特征在于，由水膨胀制成的鲨鱼架 将能量材料从所述电泳板的顶部边缘插入到两个玻璃板之间的空间中，所述鲨鱼架的顶部或底部边缘设置有多个齿，其从根部朝向尖端逐渐变细。 使用该装置，可以在凝胶电解质层上的特定泳道位置容易且积极地注入样品。
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公开(公告)号：US20140234185A1
公开(公告)日：2014-08-21
申请号：US14345777
申请日：2012-07-10
IPC分类号： B01L3/00
CPC分类号： B01L3/52 , B01L3/502715 , B01L3/523 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/044 , B01L2300/123 , B01L2400/0481 , B01L2400/0683 , G01N2001/007 , G01N2021/0346
摘要： A test reagent container includes: a bottom part; a peripheral wall part on the periphery of the bottom part; a storage part which opens upward and with an internal diameter of an inner peripheral wall decreased with depth; a film which seals the opening of the storage part; a discharge channel which penetratingly passes from an inner bottom surface of the storage part to the bottom part of the container body; a projecting part formed downwardly projecting from the bottom part to seal an outlet of the discharge channel; a breakable part including a thick-walled part and a thin-walled part thinner than the thick-walled part formed on the periphery of the projecting part. The breakable part is broken when the projecting part is depressed from outside of the container, the projecting part is inserted into the inside of the discharge channel, and the sealed state of the outlet is released.
摘要翻译： 试剂容器包括：底部; 底部周边的周壁部; 向内开口并且内周壁的内径随着深度而减小的存储部件; 密封储存部件的开口的胶片; 从储存部的内底面向容器主体的底部贯穿的排出流路; 突出部，从所述底部向下突出，以密封所述排出通道的出口; 包括厚壁部分和比形成在突出部分的周边上的厚壁部分更薄的薄壁部分的可破坏部分。 当突出部分从容器的外部压下时，可破坏的部分被破坏，突出部分插入到排放通道的内部，并且出口的密封状态被释放。
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公开(公告)号：US09221053B2
公开(公告)日：2015-12-29
申请号：US14345777
申请日：2012-07-10
CPC分类号： B01L3/52 , B01L3/502715 , B01L3/523 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/044 , B01L2300/123 , B01L2400/0481 , B01L2400/0683 , G01N2001/007 , G01N2021/0346
摘要： A test reagent container includes: a bottom part; a peripheral wall part on the periphery of the bottom part; a storage part which opens upward and with an internal diameter of an inner peripheral wall decreased with depth; a film which seals the opening of the storage part; a discharge channel which penetratingly passes from an inner bottom surface of the storage part to the bottom part of the container body; a projecting part formed downwardly projecting from the bottom part to seal an outlet of the discharge channel; a breakable part including a thick-walled part and a thin-walled part thinner than the thick-walled part formed on the periphery of the projecting part. The breakable part is broken when the projecting part is depressed from outside of the container, the projecting part is inserted into the inside of the discharge channel, and the sealed state of the outlet is released.
摘要翻译： 试剂容器包括：底部; 底部周边的周壁部; 向内开口并且内周壁的内径随着深度而减小的存储部件; 密封储存部件的开口的胶片; 从储存部的内底面向容器主体的底部贯穿的排出流路; 突出部，从所述底部向下突出，以密封所述排出通道的出口; 包括厚壁部分和比形成在突出部分的周边上的厚壁部分更薄的薄壁部分的可破坏部分。 当突出部分从容器的外部压下时，可破坏的部分被破坏，突出部分插入到排放通道的内部，并且出口的密封状态被释放。
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公开(公告)号：US20140050636A1
公开(公告)日：2014-02-20
申请号：US14114016
申请日：2012-04-20
IPC分类号： B01L3/00
CPC分类号： B01L3/52 , B01L3/5027 , B01L3/523 , B01L2200/04 , B01L2200/141 , B01L2300/044 , B01L2300/0819 , B01L2300/0832 , B01L2300/0851 , B01L2400/0683 , B65D5/726 , G01N35/00
摘要： A test reagent container including a discharge port, formed by depressing a projecting part formed on a container bottom part, through which content can be easily and reliably discharged. The test reagent container includes: a bottom part; a peripheral wall raised approximately perpendicularly from a periphery of the bottom part; and a storage part defined by the bottom part and peripheral wall. A projecting part is formed on the bottom part in a projecting manner toward outside the container. A proximal end of the projecting part is formed in a bendable manner relative to the bottom part, and an easily breakable part is formed on a periphery of the projecting part except for the proximal end of the projecting part. The easily breakable part is broken when the projecting part is depressed from outside the container to be pushed into the inside of the container to form a discharge port.
摘要翻译： 一种试剂容器，其包括通过按压形成在容器底部上的突出部分形成的排出口，通过该容器底部容易且可靠地排出内容物。 试剂容器包括：底部; 从底部的周边大致垂直地突出的周壁; 以及由底部和周壁限定的存储部。 突出部分以突出的方式形成在底部上，朝向容器外部。 突出部的近端相对于底部以可弯曲的方式形成，并且在突出部的除了突出部的近端之外的突出部的周边上形成容易断裂的部分。 当突出部分从容器外部压下以被推入容器内部以形成排出口时，容易断裂的部分被破坏。
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公开(公告)号：US20110120867A1
公开(公告)日：2011-05-26
申请号：US12674481
申请日：2008-08-22
IPC分类号： B01D57/02
CPC分类号： G01N27/44791 , G01N27/44743
摘要： The micro-channel chip for electrophoresis of the present invention comprises a first substrate formed of a gas-permeable material and a second substrate formed of a gas-permeable or a gas-impermeable material, the first and the second substrate being glued together, the mating surface of either one of the first and second substrates having a sample-feeding channel having a port at both ends and an electrophoretic channel also having a port at both ends, the sample-feeding channel and the electrophoretic channel being allowed to communicate with each other via a narrower channel having a smaller cross-sectional area than those two channels. The micro-channel chip for electrophoresis of the present invention requires only one power source to perform electrophoresis and can use samples with minimum waste of their quantity.
摘要翻译： 本发明的电泳用微通道芯片包括由透气性材料形成的第一基板和由透气性或气体不可渗透材料形成的第二基板，第一和第二基板被胶合在一起， 第一基板和第二基板中的任一个的配合表面具有在两端具有端口的采样馈送通道和在两端具有端口的电泳通道，允许采样馈送通道和电泳通道与每个 另一个通过具有比两个通道更小的横截面面积的较窄通道。 本发明的电泳用微通道芯片仅需要一个电源来进行电泳，并且可以以最少的数量浪费使用样品。
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公开(公告)号：US06773350B2
公开(公告)日：2004-08-10
申请号：US09915512
申请日：2001-07-27
IPC分类号： A63F1300
CPC分类号： A63F13/65 , A63F13/12 , A63F13/80 , A63F2300/406 , A63F2300/50 , A63F2300/8094
摘要： A game is provided based on real data which changes with time reflecting phenomena occurring in real life. In a game system 10 for providing a virtual stock trade game to players base on the real life stock price data, stock price data is obtained in almost real time from a broker etc., and stock virtually owned by the player in a game space corresponding to real life is evaluated by the stock price data. By allowing the players to compete for a time period until a target total asset value is achieved, a new player can compete under almost the same circumstances as the preceding players regardless of the timing at which they started participating in the game.
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公开(公告)号：US5552322A
公开(公告)日：1996-09-03
申请号：US313912
申请日：1994-09-28
申请人： Ryozi Nemoto , Yoshinori Mishina
发明人： Ryozi Nemoto , Yoshinori Mishina
IPC分类号： G01N21/64 , G01N27/447 , C12M1/34
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The improved DNA base sequencer comprises a flat plate type gel electrophoretic means that has a multiple of tracks for electrophoresing DNA fragments and which is held in a vertical position, a light exciting laser light applying means that applies laser light to the respective tracks in said electrophoretic means from one lateral side thereof in such a way that it crosses said tracks at right angles, and a fluorescence detecting means that detects the fluorescence as generated from the DNA fragments illuminated with the laser light and which converts the detected fluorescence to an electric signal, and it is characterized in that the fluorescence detecting means comprises an index-distributed lens array, a filter and a solid-state imaging device such as a CCD line sensor. This apparatus uses light-receiving optics that does not include a large and expensive optical device such as an image intensifier and which yet is capable of efficient fluorescence detection without "smiling" and other adverse effects.
摘要翻译： 改进的DNA碱基测序仪包括平板型凝胶电泳装置，其具有用于电泳DNA片段并保持在垂直位置的多个轨道;激光激光施加装置，其向所述电泳中的各个轨道施加激光 意指从其一个横向侧以直角穿过所述轨道的方式，以及荧光检测装置，其检测从用激光照射的DNA片段产生的荧光，并将检测到的荧光转换为电信号， 其特征在于，荧光检测装置包括折射率分布透镜阵列，滤光器和诸如CCD线传感器的固态成像装置。 该装置使用光接收光学器件，其不包括诸如图像增强器的大而昂贵的光学装置，并且其能够有效地进行荧光检测而没有“微笑”和其它不利影响。
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公开(公告)号：US09186676B2
公开(公告)日：2015-11-17
申请号：US14114016
申请日：2012-04-20
CPC分类号： B01L3/52 , B01L3/5027 , B01L3/523 , B01L2200/04 , B01L2200/141 , B01L2300/044 , B01L2300/0819 , B01L2300/0832 , B01L2300/0851 , B01L2400/0683 , B65D5/726 , G01N35/00
摘要： A test reagent container including a discharge port, formed by depressing a projecting part formed on a container bottom part, through which content can be easily and reliably discharged. The test reagent container includes: a bottom part; a peripheral wall raised approximately perpendicularly from a periphery of the bottom part; and a storage part defined by the bottom part and peripheral wall. A projecting part is formed on the bottom part in a projecting manner toward outside the container. A proximal end of the projecting part is formed in a bendable manner relative to the bottom part, and an easily breakable part is formed on a periphery of the projecting part except for the proximal end of the projecting part. The easily breakable part is broken when the projecting part is depressed from outside the container to be pushed into the inside of the container to form a discharge port.
摘要翻译： 一种试剂容器，其包括通过按压形成在容器底部上的突出部分形成的排出口，通过该容器底部容易且可靠地排出内容物。 试剂容器包括：底部; 从底部的周边大致垂直地突出的周壁; 以及由底部和周壁限定的存储部。 突出部分以突出的方式形成在底部上，朝向容器外部。 突出部的近端相对于底部以可弯曲的方式形成，并且在突出部的除了突出部的近端之外的突出部的周边上形成容易断裂的部分。 当突出部分从容器外部压下以被推入容器内部以形成排出口时，容易断裂的部分被破坏。
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9.发明申请GAME DEVICE, METHOD OF CONTROLLING A GAME DEVICE, GAME SYSTEM, PROGRAM, AND INFORMATION STORAGE MEDIUM 审中-公开游戏装置，控制游戏装置的方法，游戏系统，程序和信息存储介质公开(公告)号：US20130303245A1
公开(公告)日：2013-11-14
申请号：US13981384
申请日：2012-04-25
IPC分类号： A63F13/00
CPC分类号： A63F13/46 , A63F13/812 , A63F2300/61 , A63F2300/8011
摘要： A game system (1) executes a sport video game that uses a moving object (52), and stores evaluation standard data which associates an area (76) in a game space (30) with an evaluation standard for evaluating the result of movement of the moving object (52) from a point inside the area (76). A moving control unit (98) moves the moving object (52) from a moving start point based on the result of detection by a game operation detecting unit (96). A determining unit (100) determines whether or not the result of the movement of the moving object (52) from the moving start point satisfies an evaluation standard that is associated with the area (76) that contains the moving start point. A game operation evaluating unit (102) evaluates a game operation performed by a player based on the result of determination of the determining unit (100).
摘要翻译： 游戏系统（1）执行使用移动物体（52）的运动视频游戏，并存储将游戏空间（30）中的区域（76）与游戏空间（30）中的区域（76）相关联的评价标准数据， 所述移动物体（52）从所述区域（76）内的点移动。 移动控制单元（98）基于游戏操作检测单元（96）的检测结果，从移动起点移动移动物体（52）。 确定单元（100）确定移动对象（52）从移动开始点的移动结果是否满足与包含移动开始点的区域（76）相关联的评估标准。 游戏操作评估单元（102）基于确定单元（100）的确定结果评估玩家执行的游戏操作。
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公开(公告)号：US20090202391A1
公开(公告)日：2009-08-13
申请号：US12307403
申请日：2007-07-04
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01L3/50273 , B01L2200/12 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/12 , B01L2400/0481 , B01L2400/0633 , B01L2400/0672 , F04B43/043 , Y10T137/0318 , Y10T137/0324 , Y10T137/0352 , Y10T137/0396 , Y10T137/1624 , Y10T428/24612
摘要： There is provided by the present invention a novel micro passage chip having such a structure that a fluid can be transferred without using a physical or mechanical squeezing means that is applied from above the substrate of the micro passage chip. The micro passage chip of the present invention comprises at least a first substrate, a second substrate, and an intermediate substrate interposed between the first substrate and the second substrate and is characterized in that a first non-adhesive thin-film layer is formed on at least one of the mating sides of the first substrate and the intermediate substrate and at least one port for fluids that is in contact with the first non-adhesive thin-film layer and which is open to the outer surface of the first substrate is provided in any position on the first non-adhesive thin-film layer, and that at least a portion of a second non-adhesive thin-film layer whose length is either the same as or different from that of the first non-adhesive thin-film layer is formed on at least one of the mating sides of the second substrate and the intermediate substrate such that it lies either above or under the first non-adhesive thin-film layer, with the intermediate substrate lying in between, and a pressurizing port that is in contact with the second non-adhesive thin-film layer and which is open to the outer surface of the first or the second substrate is provided in at least one area on the second non-adhesive thin-film layer.
摘要翻译： 本发明提供了一种新颖的微通道芯片，具有这样一种结构，可以在不使用从微通道芯片的基板上方施加的物理或机械挤压装置的情况下传送流体。 本发明的微通道芯片至少包括插入在第一基板和第二基板之间的第一基板，第二基板和中间基板，其特征在于，在第一基板，第二基板和第二基板之间形成第一非粘性薄膜层 第一基板和中间基板的配合侧中的至少一个以及与第一非粘合薄膜层接触并且与第一基板的外表面开口的流体的至少一个端口设置在 在第一非粘合薄膜层上的任何位置，以及长度与第一非粘性薄膜层的长度相同或不同的第二非粘性薄膜层的至少一部分 形成在第二基板和中间基板的至少一个配合侧上，使得其位于第一非粘合薄膜层的上方或下方，中间基板位于其间，并且 在第二非粘合薄膜层上的至少一个区域上设置与第二非粘合薄膜层接触且与第一或第二基板的外表面开口的加压口。
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