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    FLOW CELLS
    1.
    发明公开
    FLOW CELLS 审中-公开

    公开(公告)号：US20230295455A1

    公开(公告)日：2023-09-21

    申请号：US18013188

    申请日：2021-10-19

    Applicant: ILLUMINA, INC.

    Inventor： Raymond Campos ,  Brian D. Mather ,  Sean M. Ramirez

    IPC: C09D133/24

    CPC classification number: C09D133/24

    Abstract: A flow cell includes a substrate and a copolymer coating. The copolymer coating includes copolymer chains, each having recurring units of formula (I): and formula (II):. In formula (I), R1 is —H, a halogen, an alkyl, an alkoxy, an alkenyl, an alkynyl, a cycloalkyl, an aryl, a heteroaryl, a heterocycle, or optionally substituted variants thereof; R2 is an azido; each (CH2)p can be optionally substituted; and p is an integer from 1 to 50. In formula (II), each of R3, R3′, R4, R4′ is —H, R5, —OR5, —C(O)OR5, —C(O)R5, —OC(O)R5, —C(O)NR6R7, or —NR6R7; R5 is —H, —OH, an alkyl, a cycloalkyl, a hydroxyalkyl, an aryl, a heteroaryl, a heterocycle, or optionally substituted variants thereof; and each of R6 and R7 is —H or an alkyl. Some copolymer chains include at least one alkoxyamine end group.

    BIOMOLECULE IMMOBILIZATION METHOD
    3.
    发明公开
    BIOMOLECULE IMMOBILIZATION METHOD 审中-公开

    公开(公告)号：US20240301487A1

    公开(公告)日：2024-09-12

    申请号：US18600605

    申请日：2024-03-08

    Applicant: ILLUMINA, INC.

    Inventor： Samantha Kelly Brittelle ,  Tyler J. Dill ,  Michelle Kate Fu ,  Ryan David McCurdy ,  Michael L. Neville ,  Sean M. Ramirez ,  Stuart A. Sardo

    IPC: C12Q1/6874 ,  C12Q1/6806

    CPC classification number: C12Q1/6874 ,  C12Q1/6806

    Abstract: In an example method, a grafting solution is applied to a patterned substrate using a liquid-phase thin-film deposition technique. The patterned substrate includes a lane surrounded by, or a plurality of depressions separated by interstitial regions; and a polymer in the lane or in each of the plurality of depressions. The polymer is functionalized with a first click reaction moiety. The grafting solution includes a solvent; a polymer matrix material dissolved in the solvent; and primers of a primer set dissolved in the solvent, each of the primers being terminated with a second click reaction moiety. The applied grafting solution is dried. During drying, a solid polymer matrix is formed and at least some of the primers attach to the polymer i) via the first and second click reaction moieties and ii) in at least a portion of the lane or in at least some of the plurality of depressions.

    NUCLEIC ACID CAPTURE, CONCENTRATION, AND PURIFICATION
    7.
    发明申请
    NUCLEIC ACID CAPTURE, CONCENTRATION, AND PURIFICATION 有权

    公开(公告)号：US20220001384A1

    公开(公告)日：2022-01-06

    申请号：US17358783

    申请日：2021-06-25

    Applicant: ILLUMINA, INC.

    Inventor： Sean M. Ramirez ,  Anmiv Prabhu ,  Rigo Pantoja ,  Michelle Higgins

    IPC: B01L3/00 ,  B01L7/00 ,  G01N35/10

    Abstract: An example of a kit includes a flow cell assembly. The flow cell assembly includes a reaction chamber, a temperature controlled flow channel in selective fluid communication with an inlet of the reaction chamber, and a filter positioned in the temperature controlled flow channel. The reaction chamber includes depressions separated by interstitial regions and capture primers attached within each of the depressions. The filter is i) to block concentrated biological sample-polymer complexes generated in the temperature controlled flow channel at a first temperature, and ii) to allow passage of concentrated biological sample and polymer released from the complexes in the temperature controlled flow channel at a second temperature.

    ARRAYS INCLUDING A RESIN FILM AND A PATTERNED POLYMER LAYER
    9.
    发明申请
    ARRAYS INCLUDING A RESIN FILM AND A PATTERNED POLYMER LAYER 审中-公开

    公开(公告)号：US20180179575A1

    公开(公告)日：2018-06-28

    申请号：US15848640

    申请日：2017-12-20

    Applicant: ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

    Inventor： Wayne N. George ,  Alexandre Richez ,  M. Shane Bowen ,  Andrew A. Brown ,  Dajun M. Yuan ,  Audrey Rose Zak ,  Sean M. Ramirez ,  Raymond Campos

    IPC: C12Q1/68 ,  C09D183/06 ,  C09D133/26

    Abstract: An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (POSS) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy POSS resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy POSS resin film, and a polymer coating is attached to the exposed discrete areas. Another example of an array includes a support, a modified epoxy POSS resin film on a surface of the support, and a patterned hydrophobic polymer layer on the modified epoxy POSS resin film. The modified epoxy POSS resin film includes a polymer growth initiation site, and the patterned hydrophobic polymer layer defines exposed discrete areas of the modified epoxy POSS resin film. A polymer brush is attached to the polymer growth initiation site in the exposed discrete areas.

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