公开(公告)号：US20240001361A1

公开(公告)日：2024-01-04

申请号：US18369587

申请日：2023-09-18

申请人： ILLUMINA, INC.

发明人： Sebastian Bohm ,  Alex Aravanis ,  Alexander Hsiao ,  Behnam Javanmardi ,  Tarun Kumar Khurana ,  Hai Quang Tran ,  Majid Aghababazadeh ,  M. Shane Bowen ,  Boyan Boyanov ,  Dale Buermann

IPC分类号： B01L3/00 ,  B01L7/00 ,  F16K99/00 ,  G01N35/08 ,  C12Q1/6869

CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L7/52 ,  F16K99/0013 ,  F16K99/0028 ,  F16K99/0015 ,  G01N35/08 ,  B01L3/502715 ,  C12Q1/6869 ,  B01L2400/0644 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  F16K2099/0084 ,  B01L2400/0655

摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

公开(公告)号：US11590494B2

公开(公告)日：2023-02-28

申请号：US16433969

申请日：2019-06-06

申请人： Illumina, inc.

发明人： Alex Aravanis ,  Boyan Boyanov ,  M. Shane Bowen ,  Dale Buermann ,  Alexander Hsiao ,  Behnam Javanmardi ,  Tarun Khurana ,  Poorya Sabounchi ,  Hai Quang Tran

IPC分类号： B01L3/00 ,  F16K99/00 ,  B01L7/00

摘要： Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

公开(公告)号：US20190283024A1

公开(公告)日：2019-09-19

申请号：US16433969

申请日：2019-06-06

申请人： Illumina, Inc.

发明人： Alex Aravanis ,  Boyan Boyanov ,  M. Shane Bowen ,  Dale Buermann ,  Alexander Hsiao ,  Behnam Javanmardi ,  Tarun Khurana ,  Poorya Sabounchi ,  Hai Quang Tran

IPC分类号： B01L3/00 ,  F16K99/00 ,  B01L7/00

摘要： Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

公开(公告)号：US20200206737A1

公开(公告)日：2020-07-02

申请号：US16818953

申请日：2020-03-13

申请人： Illumina, Inc.

发明人： Sebastian Bohm ,  Alex Aravanis ,  Alexander Hsiao ,  Behnam Javanmardi ,  Tarun Khurana ,  Hai Quang Tran ,  Majid Aghababazadeh ,  M. Shane Bowen ,  Boyan Boyanov ,  Dale Buermann

IPC分类号： B01L3/00 ,  F16K99/00 ,  C12Q1/6869 ,  B01L7/00 ,  G01N35/08

摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

公开(公告)号：US09782770B2

公开(公告)日：2017-10-10

申请号：US14712409

申请日：2015-05-14

申请人： ILLUMINA, INC.

发明人： Dale Buermann ,  Sebastian Bohm ,  Alexander Hsiao

IPC分类号： B01L3/00 ,  G01N35/00 ,  B01L3/02 ,  B01L7/00

CPC分类号： B01L3/0289 ,  B01L3/502715 ,  B01L3/502784 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0487 ,  Y10T436/11

摘要： System configured to conduct designated reactions for biological or chemical analysis. The system includes a liquid-exchange assembly comprising an assay reservoir for holding a first liquid, a receiving cavity for holding a second liquid that is immiscible with respect to the first liquid, and an exchange port fluidically connecting the assay reservoir and the receiving cavity. The system also includes a pressure activator that is operably coupled to the assay reservoir of the liquid-exchange assembly. The pressure activator is configured to repeatedly exchange the first and second liquids by (a) flowing a designated volume of the first liquid through the exchange port into the receiving cavity and (b) flowing a designated volume of the second liquid through the exchange port into the assay reservoir. The system also includes a fluidic system that is in flow communication with the liquid-exchange assembly.

公开(公告)号：US20170144155A1

公开(公告)日：2017-05-25

申请号：US15315638

申请日：2015-06-03

申请人： ILLUMINA, INC.

发明人： Sebastian Bohm ,  Alex Aravanis ,  Alexander Hsiao ,  Behnam Javanmardi ,  Tarun Khurana ,  Hai Quang Tran ,  Majid Aghababazadeh ,  M. Shane Bowen ,  Boyan Boyanov ,  Dale Buermann

IPC分类号： B01L3/00 ,  C12Q1/68 ,  B01L7/00

摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

公开(公告)号：US11786898B2

公开(公告)日：2023-10-17

申请号：US16818953

申请日：2020-03-13

申请人： Illumina, Inc.

发明人： Sebastian Bohm ,  Alex Aravanis ,  Alexander Hsiao ,  Behnam Javanmardi ,  Tarun Khurana ,  Hai Quang Tran ,  Majid Aghababazadeh ,  M. Shane Bowen ,  Boyan Boyanov ,  Dale Buermann

IPC分类号： B01L3/00 ,  B01L7/00 ,  F16K99/00 ,  G01N35/08 ,  C12Q1/6869

CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502715 ,  B01L7/52 ,  C12Q1/6869 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0028 ,  G01N35/08 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0644 ,  B01L2400/0655 ,  F16K2099/0084

摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

公开(公告)号：US20230145389A1

公开(公告)日：2023-05-11

申请号：US18087499

申请日：2022-12-22

申请人： ILLUMINA, INC.

发明人： Alex Aravanis ,  Boyan Boyanov ,  M. Shane Bowen ,  Dale Buermann ,  Alexander Hsiao ,  Behnam Javanmardi ,  Tarun Khurana ,  Poorya Sabounchi ,  Hai Quang Tran

IPC分类号： B01L3/00 ,  F16K99/00 ,  B01L7/00

CPC分类号： B01L3/502715 ,  B01L3/502738 ,  B01L7/525 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0028 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/065 ,  B01L2400/0633 ,  B01L2400/0638 ,  B01L2400/0644 ,  B01L2400/0655 ,  F16K2099/0074 ,  F16K2099/0084

摘要： Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

公开(公告)号：US20150352544A1

公开(公告)日：2015-12-10

申请号：US14712409

申请日：2015-05-14

申请人： ILLUMINA, INC.

发明人： Dale Buermann ,  Sebastian Bohm ,  Alexander Hsiao

IPC分类号： B01L3/00

CPC分类号： B01L3/0289 ,  B01L3/502715 ,  B01L3/502784 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0487 ,  Y10T436/11

摘要： System configured to conduct designated reactions for biological or chemical analysis. The system includes a liquid-exchange assembly comprising an assay reservoir for holding a first liquid, a receiving cavity for holding a second liquid that is immiscible with respect to the first liquid, and an exchange port fluidically connecting the assay reservoir and the receiving cavity. The system also includes a pressure activator that is operably coupled to the assay reservoir of the liquid-exchange assembly. The pressure activator is configured to repeatedly exchange the first and second liquids by (a) flowing a designated volume of the first liquid through the exchange port into the receiving cavity and (b) flowing a designated volume of the second liquid through the exchange port into the assay reservoir. The system also includes a fluidic system that is in flow communication with the liquid-exchange assembly.

摘要翻译： 系统配置为进行生物或化学分析的指定反应。 该系统包括液体交换组件，其包括用于保持第一液体的测定储存器，用于保持与第一液体不混溶的第二液体的接收腔以及流体连接测定储存器和接收腔的交换口。 该系统还包括可操作地耦合到液体交换组件的测定储存器的压力激活器。 压力启动器被配置为通过以下步骤来重复地交换第一和第二液体：（a）将指定体积的第一液体通过交换口流动到接收腔中，和（b）使指定体积的第二液体通过交换口流入 测定池。 该系统还包括与液体交换组件流动连通的流体系统。