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    System and method for managing a chronic medical condition
    2.
    发明申请
    System and method for managing a chronic medical condition 审中-公开
    用于管理慢性医疗状况的系统和方法

    公开(公告)号：US20050038674A1

    公开(公告)日：2005-02-17

    申请号：US10826004

    申请日：2004-04-15

    申请人： James Braig ,  Peter Rule ,  Michael Munrow ,  Philip Hartstein

    发明人： James Braig ,  Peter Rule ,  Michael Munrow ,  Philip Hartstein

    IPC分类号： G06F19/00 ,  G06Q50/00 ,  G06F17/60

    CPC分类号： G06F19/3418 ,  G06F19/3456 ,  G06Q50/22 ,  G16H10/60 ,  G16H40/40

    摘要： A system for management of a chronic medical condition generally comprises a plurality of networked physical and/or virtual elements configured to cooperate to aid in management of a chronic medical condition of a patient. The system is configured to provide a primary caregiver with current data relating to the patient's medical condition, and to allow the caregiver to provide appropriate changes to the patient's treatment via an analyte detection meter. The meter is generally configured to calculate a treatment dosage by combining a plurality of patient-affected and caregiver-affected variables. One embodiment relates to a system for management of a diabetic condition in which the primary caregiver is provided with glucose concentration data as well as other information relating to a diabetic condition. The primary caregiver can then make appropriate changes to correction factors to be implemented in an analyte detection meter which is configured to calculate an insulin dosage.

    摘要翻译： 用于管理慢性医疗状况的系统通常包括多个联网物理和/或虚拟元件，其被配置为协作以帮助管理患者的慢性医疗状况。 该系统被配置为向主要照顾者提供与患者的医疗状况相关的当前数据，并且允许护理人员通过分析物检测仪器对患者的治疗提供适当的改变。 仪器通常被配置为通过组合多个患者受影响和受照顾者影响的变量来计算治疗剂量。 一个实施方案涉及一种用于管理糖尿病状态的系统，其中主要护理者具有葡萄糖浓度数据以及与糖尿病状况有关的其它信息。 然后，主要护理者可以对被配置为计算胰岛素剂量的分析物检测计进行校正因子的适当改变。

    Analyte detection system
    3.
    发明申请
    Analyte detection system 审中-公开
    分析物检测系统

    公开(公告)号：US20050037384A1

    公开(公告)日：2005-02-17

    申请号：US10824946

    申请日：2004-04-15

    申请人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    发明人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    IPC分类号： G01N21/03 ,  G01N21/35 ,  G01N21/86 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： G01N21/8483 ,  G01N21/0303 ,  G01N21/35 ,  G01N21/3577

    摘要： Disclosed herein is a system for estimating the concentration of an analyte in a material sample. The system comprises a source of electromagnetic radiation; a detector positioned to detect radiation emitted by the source, so that the source and the detector define an optical path therebetween; and a sample element configured to be positioned in the optical path. The sample element comprises a sample chamber at least partially defined by opposed first and second windows which are substantially transmissive of at least a portion of the radiation emitted by the source, and which define an optical pathlength through the sample element. The sample chamber has an internal volume of less than 2 microliters. When the material sample is positioned in the sample chamber and the sample chamber is positioned in the optical path, the system computes estimated concentrations of the analyte in the material sample. The estimated concentrations deviate from corresponding actual concentrations of the analyte in the material sample by an RMS error of less than 15 mg/dL.

    摘要翻译： 本文公开了一种用于估计材料样品中分析物浓度的系统。 该系统包括电磁辐射源; 检测器，定位成检测由源发射的辐射，使得源和检测器在其间限定光路; 以及构造成定位在光路中的样本元件。 样品元件包括至少部分地由相对的第一和第二窗口限定的样品室，其基本上透射由源发射的辐射的至少一部分，并且通过样品元件限定光程长度。 样品室的体积小于2微升。 当材料样品定位在样品室中并且样品室位于光路中时，系统计算材料样品中分析物的估计浓度。 估计的浓度偏离材料样品中分析物的相应实际浓度，RMS误差小于15 mg / dL。

    MEMBRANE ELECTROLYZER AND HEMODIALYSIS SYSTEM USING THE SAME
    6.
    发明申请
    MEMBRANE ELECTROLYZER AND HEMODIALYSIS SYSTEM USING THE SAME 审中-公开
    使用相同的膜电解质和血液透析系统

    公开(公告)号：US20110272352A1

    公开(公告)日：2011-11-10

    申请号：US13101808

    申请日：2011-05-05

    申请人： James Braig

    发明人： James Braig

    IPC分类号： B01D61/26 ,  C12M1/12 ,  C25B1/00 ,  B01D61/28

    CPC分类号： B01D61/44 ,  A61M1/1696

    摘要： A sorbent hemodialysis system includes a dialyzer configured to receive a flow of clean dialysate from a reservoir and to output an unclean dialysate flow. The system also includes a sorbent component having a urease section and a sorbent section through which the unclean dialysate flow from the dialyzer passes, wherein the sorbent component removes urea from the dialysate. The system further comprises a membrane electrolyzer that receives at least a portion of said clean dialysate flow and separates the dialysate flow into an acidic component flow and a base component flow. A mixing conduit combines the base component flow from the membrane electrolyzer and an output dialysate solution from the urease section of the sorbent component to separate the dialysate solution into an ammonia gas amount and ammonia liquid amount. A gas vent is used to vent the ammonia gas amount, and the sorbent section with a suitable amount of zirconium phosphate (ZrP) removes the ammonia liquid amount from the unclean dialysate flow before flowing the clean dialysate to the reservoir. The system can further include a second mixing conduit upstream of the sorbent section of the sorbent component, the second mixing conduit combining the acidic component flow and the ammonia liquid amount in the dialysate solution to increase the pH of the dialysate solution to about 7.5 prior to returning to the reservoir.

    摘要翻译： 吸附剂血液透析系统包括透析器，其构造成从储存器接收干净的透析液流并输出不洁净的透析液流。 该系统还包括具有尿素酶部分和吸附剂部分的吸附剂组分，来自透析器的不洁透析液流过该吸附剂部分，其中吸附剂组分从透析液中除去尿素。 所述系统还包括膜电解器，其接收所述清洁透析液流的至少一部分，并将透析液流分离成酸性组分流和碱组分流。 混合导管结合来自膜电解器的基础组分流和来自吸附剂组分的脲酶部分的输出透析液，将透析液分离成氨气量和氨液量。 使用排气口排出氨气量，并且使用适量的磷酸锆（ZrP）的吸附剂部分从清洁的透析液流中除去氨液体量，然后将清洁的透析液流入储存器。 该系统还可以包括在吸附剂组分的吸附剂部分上游的第二混合管道，第二混合管道将酸性组分流和氨液体量结合在透析液中，以将透析液的pH值升高到约7.5，之后 回到水库。

    Apparatus and methods for analyzing body fluid samples
    8.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20070060872A1

    公开(公告)日：2007-03-15

    申请号：US11352956

    申请日：2006-02-13

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00 ,  A61D5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Apparatus and methods for analyzing body fluid samples
    10.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20060189926A1

    公开(公告)日：2006-08-24

    申请号：US11316407

    申请日：2005-12-21

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.