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    MEMBRANE ELECTROLYZER AND HEMODIALYSIS SYSTEM USING THE SAME
    1.
    发明申请
    MEMBRANE ELECTROLYZER AND HEMODIALYSIS SYSTEM USING THE SAME 审中-公开
    使用相同的膜电解质和血液透析系统

    公开(公告)号：US20110272352A1

    公开(公告)日：2011-11-10

    申请号：US13101808

    申请日：2011-05-05

    申请人： James Braig

    发明人： James Braig

    IPC分类号： B01D61/26 ,  C12M1/12 ,  C25B1/00 ,  B01D61/28

    CPC分类号： B01D61/44 ,  A61M1/1696

    摘要： A sorbent hemodialysis system includes a dialyzer configured to receive a flow of clean dialysate from a reservoir and to output an unclean dialysate flow. The system also includes a sorbent component having a urease section and a sorbent section through which the unclean dialysate flow from the dialyzer passes, wherein the sorbent component removes urea from the dialysate. The system further comprises a membrane electrolyzer that receives at least a portion of said clean dialysate flow and separates the dialysate flow into an acidic component flow and a base component flow. A mixing conduit combines the base component flow from the membrane electrolyzer and an output dialysate solution from the urease section of the sorbent component to separate the dialysate solution into an ammonia gas amount and ammonia liquid amount. A gas vent is used to vent the ammonia gas amount, and the sorbent section with a suitable amount of zirconium phosphate (ZrP) removes the ammonia liquid amount from the unclean dialysate flow before flowing the clean dialysate to the reservoir. The system can further include a second mixing conduit upstream of the sorbent section of the sorbent component, the second mixing conduit combining the acidic component flow and the ammonia liquid amount in the dialysate solution to increase the pH of the dialysate solution to about 7.5 prior to returning to the reservoir.

    摘要翻译： 吸附剂血液透析系统包括透析器，其构造成从储存器接收干净的透析液流并输出不洁净的透析液流。 该系统还包括具有尿素酶部分和吸附剂部分的吸附剂组分，来自透析器的不洁透析液流过该吸附剂部分，其中吸附剂组分从透析液中除去尿素。 所述系统还包括膜电解器，其接收所述清洁透析液流的至少一部分，并将透析液流分离成酸性组分流和碱组分流。 混合导管结合来自膜电解器的基础组分流和来自吸附剂组分的脲酶部分的输出透析液，将透析液分离成氨气量和氨液量。 使用排气口排出氨气量，并且使用适量的磷酸锆（ZrP）的吸附剂部分从清洁的透析液流中除去氨液体量，然后将清洁的透析液流入储存器。 该系统还可以包括在吸附剂组分的吸附剂部分上游的第二混合管道，第二混合管道将酸性组分流和氨液体量结合在透析液中，以将透析液的pH值升高到约7.5，之后 回到水库。

    Apparatus and methods for analyzing body fluid samples
    3.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20070060872A1

    公开(公告)日：2007-03-15

    申请号：US11352956

    申请日：2006-02-13

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00 ,  A61D5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Apparatus and methods for analyzing body fluid samples
    5.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20060189926A1

    公开(公告)日：2006-08-24

    申请号：US11316407

    申请日：2005-12-21

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    NOISE REDUCTION FOR ANALYTE DETECTION SYSTEMS
    7.
    发明申请
    NOISE REDUCTION FOR ANALYTE DETECTION SYSTEMS 审中-公开
    用于分析仪检测系统的噪声减少

    公开(公告)号：US20070258083A1

    公开(公告)日：2007-11-08

    申请号：US11734261

    申请日：2007-04-11

    申请人： Kevin Heppell ,  James Braig

    发明人： Kevin Heppell ,  James Braig

    IPC分类号： G01N33/48

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  G01N21/07 ,  G01N21/274 ,  G01N21/35

    摘要： Methods and apparatus are provided for determining the concentration of an analyte in a sample, such as an analyte in a sample of bodily fluid. Some embodiments use a synchronous demodulator and digital filter to reduce microphonic signal content. Some embodiments monitor the microphonic signal content and “hold off” on making a measurement until vibrations subside. Monitoring can be performed using an accelerometer or other vibration sensor. An algorithm can be used to examine the detector output signal and detect excessive microphonic components, making an accelerometer unnecessary.

    摘要翻译： 提供了用于确定样品（例如体液样品中的分析物）中的分析物的浓度的方法和装置。 一些实施例使用同步解调器和数字滤波器来减少麦克风信号内容。 一些实施例监视麦克风信号内容并在进行测量时“保持”，直到振动消退。 可以使用加速度计或其他振动传感器进行监视。 可以使用一种算法来检测检测器输出信号并检测过多的麦克风分量，使加速度计不必要。

    Spectroscopic analysis of a biological fluid reacted with an enzyme
    8.
    发明申请
    Spectroscopic analysis of a biological fluid reacted with an enzyme 审中-公开
    与酶反应的生物液体的光谱分析

    公开(公告)号：US20060292650A1

    公开(公告)日：2006-12-28

    申请号：US11438902

    申请日：2006-05-23

    申请人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

    发明人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

    IPC分类号： C12Q1/54 ,  C12M1/34

    CPC分类号： C12Q1/26 ,  C12Q1/32 ,  C12Q1/52 ,  C12Q1/54

    摘要： An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.

    摘要翻译： 提出了使用组合酶分光法估计分析物浓度的装置。 提供葡萄糖和乳酸盐检测的实例。 将生物流体样品与特定于目标分析物的酶混合或接触，并且反应流体用波长包括至少一种对分析物浓度敏感的波长和至少一种波长的光学系统进行探测 对分析物浓度不敏感。 光学系统测量诸如光密度的特性，并通过校准系统将测量值与浓度相关联。 还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。 这些技术可以应用于连续或周期性的患者采样系统或测试条型设备。

    Analyte detection system for multiple analytes
    10.
    发明申请
    Analyte detection system for multiple analytes 有权
    多种分析物的分析物检测系统

    公开(公告)号：US20060189858A1

    公开(公告)日：2006-08-24

    申请号：US11314176

    申请日：2005-12-21

    申请人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    发明人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    IPC分类号： A61B5/00 ,  A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

    摘要翻译： 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。 在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。