公开(公告)号：US20050038674A1

公开(公告)日：2005-02-17

申请号：US10826004

申请日：2004-04-15

申请人： James Braig ,  Peter Rule ,  Michael Munrow ,  Philip Hartstein

发明人： James Braig ,  Peter Rule ,  Michael Munrow ,  Philip Hartstein

IPC分类号： G06F19/00 ,  G06Q50/00 ,  G06F17/60

CPC分类号： G06F19/3418 ,  G06F19/3456 ,  G06Q50/22 ,  G16H10/60 ,  G16H40/40

摘要： A system for management of a chronic medical condition generally comprises a plurality of networked physical and/or virtual elements configured to cooperate to aid in management of a chronic medical condition of a patient. The system is configured to provide a primary caregiver with current data relating to the patient's medical condition, and to allow the caregiver to provide appropriate changes to the patient's treatment via an analyte detection meter. The meter is generally configured to calculate a treatment dosage by combining a plurality of patient-affected and caregiver-affected variables. One embodiment relates to a system for management of a diabetic condition in which the primary caregiver is provided with glucose concentration data as well as other information relating to a diabetic condition. The primary caregiver can then make appropriate changes to correction factors to be implemented in an analyte detection meter which is configured to calculate an insulin dosage.

摘要翻译： 用于管理慢性医疗状况的系统通常包括多个联网物理和/或虚拟元件，其被配置为协作以帮助管理患者的慢性医疗状况。 该系统被配置为向主要照顾者提供与患者的医疗状况相关的当前数据，并且允许护理人员通过分析物检测仪器对患者的治疗提供适当的改变。 仪器通常被配置为通过组合多个患者受影响和受照顾者影响的变量来计算治疗剂量。 一个实施方案涉及一种用于管理糖尿病状态的系统，其中主要护理者具有葡萄糖浓度数据以及与糖尿病状况有关的其它信息。 然后，主要护理者可以对被配置为计算胰岛素剂量的分析物检测计进行校正因子的适当改变。

公开(公告)号：US20050036146A1

公开(公告)日：2005-02-17

申请号：US10824933

申请日：2004-04-15

申请人： James Braig ,  Kenneth Witte ,  Philip Hartstein ,  Ken Li ,  Peter Rule

发明人： James Braig ,  Kenneth Witte ,  Philip Hartstein ,  Ken Li ,  Peter Rule

IPC分类号： G01N21/03 ,  G01N21/59 ,  G01N21/86 ,  G01N35/00 ,  G01N21/00

CPC分类号： G01N35/00732 ,  G01N21/03 ,  G01N21/5907 ,  G01N21/8483 ,  G01N2035/00752 ,  G01N2035/00762 ,  G01N2035/00772 ,  G01N2035/00782

摘要： A sample element includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.

摘要翻译： 样品元件包括由中间构件分隔开的第一和第二基本上平行的面。 平行面和中间构件至少部分地限定了构造成保持一定体积的流体的样品室。 样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。 样本元件还包括设置在至少一个平行面内或之中的识别化合物。 识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。 通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

公开(公告)号：US20060004267A1

公开(公告)日：2006-01-05

申请号：US11173768

申请日：2005-07-01

申请人： Peter Rule ,  James Braig ,  Philip Hartstein

发明人： Peter Rule ,  James Braig ,  Philip Hartstein

IPC分类号： A61B5/00

CPC分类号： B01L3/5023 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1491 ,  B01L3/5027 ,  B01L3/508 ,  B01L2200/027 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/03 ,  G01N21/8483 ,  G01N2021/0346

摘要： A spectroscopic sample holder comprises a microporous sheet. The microporous sheet has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening configured to contact a material sample and distribute the contacted material sample into the microporous sheet. The spectroscopic sample holder further comprises a first planar support member positioned on, and substantially parallel to, the top surface of the microporous sheet. The spectroscopic sample holder further comprises a second planar support member positioned on the bottom surface of the microporous sheet, and oriented substantially parallel to the first planar support member.

摘要翻译： 光谱样品架包括微孔片。 微孔片具有基本平行于顶表面的顶表面，底表面以及基本上垂直于顶表面和底表面取向的至少一个侧表面。 侧表面形成暴露的转移开口，其构造成接触材料样品并将接触的材料样品分配到微孔板中。 光谱样品架还包括位于微孔板的顶表面上且基本上平行于微孔板的顶表面的第一平面支撑构件。 光谱样品架还包括位于微孔板的底表面上并基本上平行于第一平面支撑构件定向的第二平面支撑构件。

公开(公告)号：US20060030790A1

公开(公告)日：2006-02-09

申请号：US10913666

申请日：2004-08-06

申请人： James Braig ,  Peter Rule ,  Philip Hartstein ,  Heidi Smith

发明人： James Braig ,  Peter Rule ,  Philip Hartstein ,  Heidi Smith

IPC分类号： A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15136 ,  A61B5/1514 ,  A61B2562/0295

摘要： Disclosed is a sample element for holding a volume of bodily fluid drawn from the skin of a patient at a withdrawal site. The sample element comprises a housing defining a sample chamber therein, and a barrier. The sample element also comprises a vacuum source. The barrier has a first side configured to contact the skin of the patient at the withdrawal site, and a second side in fluid communication with the sample chamber. The barrier is configured to be pierced by a lance to permit the bodily fluid to pass from the first side to the second side. Additionally, the vacuum source can be actuated to draw the bodily fluid through the barrier and into the sample chamber. Also disclosed is a method of drawing a bodily fluid form the skin of a patient at a withdrawal site. The method comprises placing a first side of a barrier against the skin of the patient at the withdrawal site. The method further comprises forming a first opening through the barrier and a second opening in the skin of the patient at the withdrawal site. The first and second openings are in fluid communication. The method further comprises applying suction at the first opening of the barrier to draw a bodily fluid from the patient.

摘要翻译： 公开了一种用于在取出部位保持从患者皮肤抽取的体液体积的样本元件。 样品元件包括在其中限定样品室的壳体和屏障。 样品元件还包括真空源。 屏障具有被配置成在抽出部位接触患者皮肤的第一侧和与样品室流体连通的第二侧。 障碍物被构造成被喷枪刺穿以允许体液从第一侧通过到第二侧。 此外，可以致动真空源以将体液通过屏障并进入样品室。 还公开了一种在抽出部位从患者的皮肤上吸取体液的方法。 该方法包括将屏障的第一侧放置在患者的皮肤处于撤出部位。 所述方法还包括在所述抽出部位形成穿过所述屏障的第一开口和所述患者皮肤中的第二开口。 第一和第二开口处于流体连通状态。 该方法还包括在屏障的第一开口处施加抽吸以从患者抽取体液。

公开(公告)号：US20050106749A1

公开(公告)日：2005-05-19

申请号：US10877965

申请日：2004-06-25

申请人： James Braig ,  Bernhard Sterling ,  Peter Rule ,  Philip Hartstein ,  Kenneth Li

发明人： James Braig ,  Bernhard Sterling ,  Peter Rule ,  Philip Hartstein ,  Kenneth Li

IPC分类号： G01N21/03 ,  G01N21/35 ,  G01N21/86 ,  G01N31/22

CPC分类号： G01N21/8483 ,  G01N21/0303 ,  G01N21/3577

摘要： A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The method further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.

摘要翻译： 提供了用于确定材料样品中分析物浓度的系统和方法。 所述方法包括提供样品室，所述样品室至少部分地由至少一个窗口形成，所述至少一个窗口由从其入射的电磁辐射的吸收率具有大于约1％波长域的变化的材料形成。 该方法还包括使用样品元件分析物检测系统，其以临床可接受的精度确定分析物的浓度。

公开(公告)号：US20050037482A1

公开(公告)日：2005-02-17

申请号：US10826006

申请日：2004-04-15

申请人： James Braig ,  Peter Rule ,  Kenneth Witte ,  Philip Hartstein ,  Bernhard Sterling

发明人： James Braig ,  Peter Rule ,  Kenneth Witte ,  Philip Hartstein ,  Bernhard Sterling

IPC分类号： A61B5/00 ,  C12M1/34

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546

摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.

摘要翻译： 分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。 第二分析物的测量可以对第一次测量的定量或定性结果进行调节。 在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。 根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

公开(公告)号：US20050070771A1

公开(公告)日：2005-03-31

申请号：US10900062

申请日：2004-07-27

申请人： Peter Rule ,  James Braig ,  Philip Hartstein ,  Jennifer Gable

发明人： Peter Rule ,  James Braig ,  Philip Hartstein ,  Jennifer Gable

IPC分类号： A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1491

摘要： An adapter presents a sample of bodily fluid, such as whole blood, including an analyte to an analyzer window of a non-invasive monitor. The adapter comprises a base material that comprises a first side and a second side. The adapter also comprises a sample accommodating volume extending between an opening in the second side of the base material and an opening in the first side of the base material.

摘要翻译： 适配器将诸如全血的体液样品（包括分析物）提供给非侵入性监测器的分析器窗口。 适配器包括包括第一侧和第二侧的基材。 适配器还包括在基材的第二侧的开口和基材的第一侧中的开口之间延伸的样品容纳体积。

公开(公告)号：US20050038357A1

公开(公告)日：2005-02-17

申请号：US10825223

申请日：2004-04-15

申请人： Philip Hartstein ,  James Braig

发明人： Philip Hartstein ,  James Braig

IPC分类号： A61B5/00 ,  A61B5/15 ,  B01L3/00 ,  G01N21/03

CPC分类号： A61B5/15194 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150412 ,  A61B5/150755 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/1519 ,  A61B2562/0295 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N21/0303

摘要： Disclosed is a sample element for holding a volume of bodily fluid drawn from the skin of a patient at a withdrawal site. The sample element comprises a housing defining a sample chamber therein, and a barrier. The barrier has a first side configured to contact the skin of the patient at the withdrawal site, and a second side in fluid communication with the sample chamber. The barrier is configured to be pierced by a lance, to permit the bodily fluid to pass from the first side to the second side. Also disclosed is a method of drawing a bodily fluid from the skin of a patient at a withdrawal site. The method comprises placing a first side of a barrier against the skin of the patient at the withdrawal site. The method further comprises forming a first opening through the barrier and a second opening in the skin of the patient at the withdrawal site. The first opening and the second opening are in fluid communication. The method further comprises placing a sample chamber in fluid communication with a second side of the barrier.

摘要翻译： 公开了一种用于在取出部位保持从患者皮肤抽取的体液体积的样本元件。 样品元件包括在其中限定样品室的壳体和屏障。 屏障具有被配置成在抽出部位接触患者皮肤的第一侧和与样品室流体连通的第二侧。 障碍物被构造成被喷枪刺穿，以允许体液从第一侧通过到第二侧。 还公开了一种在抽出部位从患者皮肤抽取体液的方法。 该方法包括将屏障的第一侧放置在患者的皮肤处于撤出部位。 所述方法还包括在所述抽出部位形成穿过所述屏障的第一开口和所述患者皮肤中的第二开口。 第一开口和第二开口处于流体连通状态。 该方法还包括将样品室放置成与屏障的第二侧流体连通。

公开(公告)号：US20050036147A1

公开(公告)日：2005-02-17

申请号：US10825085

申请日：2004-04-15

申请人： Bernhard Sterling ,  James Braig ,  Daniel Goldberger ,  Philip Hartstein ,  Robert Gaffney

发明人： Bernhard Sterling ,  James Braig ,  Daniel Goldberger ,  Philip Hartstein ,  Robert Gaffney

IPC分类号： A61B5/00 ,  G01N21/31 ,  G01N21/35 ,  G01N21/59

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  G01N21/03 ,  G01N21/314 ,  G01N21/35

摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.

摘要翻译： 一种方法确定样品中的分析物浓度。 样品包括分析物和物质。 该方法包括提供样品的吸收数据。 该方法还包括提供该物质的参考吸收数据。 该方法还包括计算吸收数据的物质贡献。 该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

公开(公告)号：US20050238538A1

公开(公告)日：2005-10-27

申请号：US11106352

申请日：2005-04-14

申请人： James Braig ,  Gary Hewett ,  Michael Munrow ,  Julian Cortella ,  Kamrava Azizi ,  Daniel Goldberger

发明人： James Braig ,  Gary Hewett ,  Michael Munrow ,  Julian Cortella ,  Kamrava Azizi ,  Daniel Goldberger

IPC分类号： A61B5/00 ,  G06F19/00 ,  G01N21/00

CPC分类号： A61B5/1495 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0271 ,  A61B2562/0295 ,  G06F19/3418 ,  G16H40/40 ,  G16H40/63 ,  Y10S707/99945

摘要： An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection system has a processor that calculates analyte concentration in accordance with software executable by the processor. Under certain conditions, the software needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.