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    Biphenyl derivatives substituted by an aromatic or heteroaromatic radical and pharamaceutical and cosmetic compositions containing same
    2.
    发明授权
    Biphenyl derivatives substituted by an aromatic or heteroaromatic radical and pharamaceutical and cosmetic compositions containing same 失效
    由芳族或杂芳族基团取代的联苯衍生物和含有它们的药物和化妆品组合物

    公开(公告)号：US06316009B1

    公开(公告)日：2001-11-13

    申请号：US09284026

    申请日：1999-04-06

    申请人： Jean-Michel Bernardon ,  Philippe Nedoncelle

    发明人： Jean-Michel Bernardon ,  Philippe Nedoncelle

    IPC分类号： A61K748

    CPC分类号： C07C65/26 ,  C07C65/17 ,  C07C69/94

    摘要： “Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them” in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R2 and R3, taken together, form a 5- or 6-membered ring, R4 and R5 represent, in particular, H or halogen, R6 represents, in particular, H or lower alkyl, and the salts of the compounds of formula (I). These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.

    摘要翻译： “芳基或杂芳基取代的联苯衍生物，含有它们的药物和化妆品组合物”，其中：Ar表示任选被烷基或羧基取代的芳族或杂芳族基，R2和R3表示 特别地，H或烷基，或R 2和R 3一起形成5-或6-元环，R 4和R 5特别表示H或卤素，R 6特别表示H或低级烷基， 式（I）化合物。这些化合物特别可用于治疗与角质化病症有关的皮肤病学反应，并用于对抗皮肤老化。

    Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them
    4.
    发明授权
    Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them 失效
    被芳族或杂芳族基团取代的联苯衍生物，以及含有它们的药物和化妆品组合物

    公开(公告)号：US06649612B1

    公开(公告)日：2003-11-18

    申请号：US09932938

    申请日：2001-08-21

    申请人： Jean-Michel Bernardon ,  Philippe Nedoncelle

    发明人： Jean-Michel Bernardon ,  Philippe Nedoncelle

    IPC分类号： A61K748

    CPC分类号： C07C65/26 ,  C07C65/17 ,  C07C69/94

    摘要： Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R2 and R3, taken together, form a 5- or 6-membered ring, R4 and R5 represent, in particular, H or halogen, R6 represents, in particular, H or lower alkyl, and the salts of the compounds of formula (I). These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.

    摘要翻译： 式（I）化合物：其中：Ar表示任选被烷基或羧基取代的芳香族或杂芳族基，R2和R3特别表示H或烷基，或R 2和R 3一起 形成5-或6-元环，R 4和R 5特别表示H或卤素，R 6表示特别是H或低级烷基，以及式（I）化合物的盐。这些化合物可以是 特别用于治疗与角质化障碍相关的皮肤病学反应，并用于对抗皮肤老化。

    Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them
    9.
    发明授权
    Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them 失效
    被芳族或杂芳族基团取代的联苯衍生物，以及含有它们的药物和化妆品组合物

    公开(公告)号：US07148245B2

    公开(公告)日：2006-12-12

    申请号：US10613320

    申请日：2003-07-07

    申请人： Jean-Michel Bernardon ,  Philippe Nedoncelle

    发明人： Jean-Michel Bernardon ,  Philippe Nedoncelle

    IPC分类号： A61K8/49 ,  A61K31/4418 ,  C07D213/06

    CPC分类号： C07C65/26 ,  C07C65/17 ,  C07C69/94

    摘要： Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R2 and R3, taken together, form a 5- or 6-membered ring, R4 and R5 represent, in particular, H or halogen, R6 represents, in particular, H or lower alkyl, and the salts of the compounds of formula (I). These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.

    摘要翻译： 式（I）的化合物：其中：Ar表示任选被烷基或羧基取代的芳族或杂芳族基，R 2和R 3 >特别地表示H或烷基，或R 2和R 3 3一起形成5-或6-元环，R 4， R 3和R 5特别表示H或卤素，R 6表示，特别是H或低级烷基，式（I）化合物的盐 一世）。 这些化合物特别可用于治疗与角质化障碍相关的皮肤病学反应，并且用于对抗皮肤老化。