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    Combination Imaging and Therapy Transducer With Therapy Transducer Amplifier
    1.
    发明申请
    Combination Imaging and Therapy Transducer With Therapy Transducer Amplifier 有权
    组合成像和治疗传感器与治疗传感器放大器

    公开(公告)号：US20080228075A1

    公开(公告)日：2008-09-18

    申请号：US12064309

    申请日：2006-08-25

    申请人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    发明人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    IPC分类号： A61B8/00

    CPC分类号： A61B17/22004 ,  A61B8/0833 ,  A61B8/14 ,  A61B8/4405 ,  A61B8/481 ,  A61B17/2256 ,  A61B2017/22028 ,  A61B2090/378 ,  G01S15/8918 ,  G01S15/8977

    摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14). First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

    摘要翻译： 组合的超声成像和治疗换能器（10）包括成像换能器元件（14）的线性阵列。 治疗换能器元件（18,20）的第一和第二线性阵列沿着成像换能器元件的相应的第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在 的凝块。

    Combination imaging and therapy transducer with therapy transducer amplifier
    2.
    发明授权
    Combination imaging and therapy transducer with therapy transducer amplifier 有权
    组合成像和治疗传感器与治疗传感器放大器

    公开(公告)号：US09198680B2

    公开(公告)日：2015-12-01

    申请号：US12064309

    申请日：2006-08-25

    申请人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    发明人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    IPC分类号： A61B8/00 ,  A61B8/12 ,  A61B17/22 ,  A61B8/08 ,  A61B8/14 ,  A61B17/225 ,  G01S15/89 ,  A61B19/00

    CPC分类号： A61B17/22004 ,  A61B8/0833 ,  A61B8/14 ,  A61B8/4405 ,  A61B8/481 ,  A61B17/2256 ,  A61B2017/22028 ,  A61B2090/378 ,  G01S15/8918 ,  G01S15/8977

    摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14). First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

    摘要翻译： 组合的超声成像和治疗换能器（10）包括成像换能器元件（14）的线性阵列。 治疗换能器元件（18,20）的第一和第二线性阵列沿着成像换能器元件的相应的第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在 的凝块。

    Method of Using a Combination Imaging and Therapy transducer to Dissolve Blood Clots
    3.
    发明申请
    Method of Using a Combination Imaging and Therapy transducer to Dissolve Blood Clots 有权
    使用组合成像和治疗传感器溶解血液凝块的方法

    公开(公告)号：US20080249409A1

    公开(公告)日：2008-10-09

    申请号：US12065343

    申请日：2006-08-25

    申请人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    发明人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    IPC分类号： A61N7/00 ,  A61B8/00

    CPC分类号： A61N7/02 ,  A61B8/0833 ,  A61B8/14 ,  A61B8/4405 ,  A61B8/481 ,  A61B2017/22008 ,  A61B2090/378 ,  A61N2007/0078

    摘要： A combined ultrasound imaging and therapy transducer includes a linear array of imaging transducer elements. First and second linear arrays of therapy transducer elements extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

    摘要翻译： 组合的超声成像和治疗换能器包括成像换能器元件的线性阵列。 治疗换能器元件的第一和第二线性阵列沿着成像换能器元件的相应第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中的微泡再灌注，或继续存在 的凝块。

    Method of using a combination imaging and therapy transducer to dissolve blood clots
    4.
    发明授权
    Method of using a combination imaging and therapy transducer to dissolve blood clots 有权
    使用组合成像和治疗传感器来溶解血块的方法

    公开(公告)号：US08012092B2

    公开(公告)日：2011-09-06

    申请号：US12065343

    申请日：2006-08-25

    申请人： Jeffry E. Powers ,  John Fraser ,  Michalakis Averkiou

    发明人： Jeffry E. Powers ,  John Fraser ,  Michalakis Averkiou

    IPC分类号： A61B8/14 ,  A61B7/00

    CPC分类号： A61N7/02 ,  A61B8/0833 ,  A61B8/14 ,  A61B8/4405 ,  A61B8/481 ,  A61B2017/22008 ,  A61B2090/378 ,  A61N2007/0078

    摘要： A combined ultrasound imaging and therapy transducer includes a linear array of imaging transducer elements. First and second linear arrays of therapy transducer elements extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

    摘要翻译： 组合的超声成像和治疗换能器包括成像换能器元件的线性阵列。 治疗换能器元件的第一和第二线性阵列沿着成像换能器元件的相应第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在 的凝块。

    Combination Imaging and Therapy Transducer
    5.
    发明申请
    Combination Imaging and Therapy Transducer 审中-公开
    组合成像和治疗传感器

    公开(公告)号：US20080319316A1

    公开(公告)日：2008-12-25

    申请号：US12064316

    申请日：2006-08-25

    申请人： Jeffry E. Powers ,  John Fraser ,  Michalakis Averkiou

    发明人： Jeffry E. Powers ,  John Fraser ,  Michalakis Averkiou

    IPC分类号： A61B8/14 ,  A61N7/00

    CPC分类号： A61B8/14 ,  A61B8/0833 ,  A61B8/4405 ,  A61B8/481 ,  A61B17/22004 ,  A61B17/2256 ,  A61B2017/22028 ,  A61B2090/378 ,  A61N7/00 ,  G01S15/8918 ,  G01S15/899

    摘要： A combined ultrasound imaging and therapy transducer includes a linear array of imaging transducer elements. First and second linear arrays of therapy transducer elements extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

    摘要翻译： 组合的超声成像和治疗换能器包括成像换能器元件的线性阵列。 治疗换能器元件的第一和第二线性阵列沿着成像换能器元件的相应第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在 的凝块。

    Systems and methods for treating patients with processed lipoaspirate cells
    6.
    发明申请
    Systems and methods for treating patients with processed lipoaspirate cells 有权
    用于治疗患有脂溢性胃炎细胞的患者的系统和方法

    公开(公告)号：US20070036768A1

    公开(公告)日：2007-02-15

    申请号：US11584202

    申请日：2006-10-20

    申请人： John Fraser ,  Marc Hedrick

    发明人： John Fraser ,  Marc Hedrick

    IPC分类号： A61K35/12 ,  C12N5/08 ,  C12M3/00

    CPC分类号： A61K35/28 ,  A61B10/0283 ,  A61K9/0019 ,  A61K35/35 ,  A61M1/0039 ,  A61M2202/08 ,  C12M47/04 ,  C12N5/0667 ,  C12N5/069 ,  C12N2506/1384 ,  G06F19/00

    摘要： Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.

    摘要翻译： 存在于加工的lipoaspirate组织中的细胞用于治疗患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 施用于患者的组合物包括脂肪组织和干细胞的混合物，使得组合物具有比从患者中除去脂肪组织时更高浓度的干细胞。

    Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
    8.
    发明申请
    Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders 审中-公开
    使用再生细胞治疗外周血管疾病和相关疾病的方法

    公开(公告)号：US20050095228A1

    公开(公告)日：2005-05-05

    申请号：US10884871

    申请日：2004-07-01

    申请人： John Fraser ,  Marc Hedrick ,  Eric Daniels

    发明人： John Fraser ,  Marc Hedrick ,  Eric Daniels

    IPC分类号： A61K35/28 ,  A61K35/44 ,  A61K45/00

    CPC分类号： A61K35/28 ,  A61K9/0019 ,  A61K35/44 ,  A61K45/06 ,  A61L27/3834 ,  A61L27/3886 ,  A61L2300/64 ,  A61L2430/00 ,  A61L2430/36 ,  C12N5/0667 ,  C12N5/069 ,  C12N2506/1384

    摘要： Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.

    摘要翻译： 存在于脂肪组织中的细胞用于治疗患者，包括患有PVD和相关疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。