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    Substituted pyrimidine derivatives
    2.
    发明申请
    Substituted pyrimidine derivatives 失效
    取代的嘧啶衍生物

    公开(公告)号：US20050101613A1

    公开(公告)日：2005-05-12

    申请号：US10839055

    申请日：2004-05-05

    申请人： Jeffrey Corbett ,  Michael Ennis ,  Kristine Frank ,  Jian-Min Fu ,  Robert Hoffman ,  Patrick Verhoest

    发明人： Jeffrey Corbett ,  Michael Ennis ,  Kristine Frank ,  Jian-Min Fu ,  Robert Hoffman ,  Patrick Verhoest

    IPC分类号： C07D213/72 ,  C07D239/42 ,  A61K31/506 ,  A61K31/4439 ,  C07D43/02

    CPC分类号： C07D239/42 ,  C07D213/72

    摘要： This invention relates to compounds of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug thereof. The compounds interact with CRF, receptors, including human CRF, receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety-related disorders such as anxiety, and mood disorders such as major depression.

    摘要翻译： 本发明涉及式I化合物，其立体异构体，其药学上可接受的盐，其前药或其前药的药学上可接受的盐。 该化合物与CRF，受体（包括人类CRF）受体相互作用。 本发明还涉及使用本发明化合物治疗病症或病症的方法，所述疾病或病症的治疗可以通过拮抗CRF受体如CNS疾病或疾病，特别是焦虑相关疾病例如焦虑来实现或促进 ，以及心理障碍如重度抑郁症。

    SUBSTITUTED PYRIMIDINE DERIVATIVES
    5.
    发明申请
    SUBSTITUTED PYRIMIDINE DERIVATIVES 审中-公开
    取代的吡咯烷衍生物

    公开(公告)号：US20060217398A1

    公开(公告)日：2006-09-28

    申请号：US11424073

    申请日：2006-06-14

    申请人： Jeffrey Corbett ,  Micheal Ennis ,  Kristine Frank ,  Jian-Min Fu ,  Robert Hoffman ,  Patrick Verhoest

    发明人： Jeffrey Corbett ,  Micheal Ennis ,  Kristine Frank ,  Jian-Min Fu ,  Robert Hoffman ,  Patrick Verhoest

    IPC分类号： A61K31/506 ,  A61K31/4439

    CPC分类号： C07D239/42 ,  C07D213/72

    摘要： This invention relates to compounds of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug thereof. The compounds interact with CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety-related disorders such as anxiety, and mood disorders such as major depression.

    摘要翻译： 本发明涉及式I化合物，其立体异构体，其药学上可接受的盐，其前药或其前药的药学上可接受的盐。 这些化合物与CRF1受体（包括人CRF 1受体）相互作用。 本发明还涉及使用本发明化合物治疗病症或病症的方法，所述疾病或病症的治疗可以通过拮抗CRF受体如CNS疾病或疾病，特别是焦虑相关疾病例如焦虑来实现或促进 ，以及心理障碍如重度抑郁症。

    Conformal coating applicator and method
    8.
    发明申请
    Conformal coating applicator and method 有权
    保形涂布机和方法

    公开(公告)号：US20050095365A1

    公开(公告)日：2005-05-05

    申请号：US10697193

    申请日：2003-10-30

    申请人： Howard Acum ,  Robert Hoffman ,  Jacques Mycke ,  Todd Weston

    发明人： Howard Acum ,  Robert Hoffman ,  Jacques Mycke ,  Todd Weston

    IPC分类号： B05B7/06 ,  B05B7/08 ,  B05B7/10 ,  B05C5/00 ,  B05C5/02 ,  B05D1/02 ,  H05K3/00

    CPC分类号： B05B7/066 ,  B05B7/0815 ,  B05B7/10 ,  B05C5/0225 ,  H05K3/0091 ,  H05K2203/0126

    摘要： An applicator for dispensing a conformal coating material onto a substrate. The applicator has a body with a nozzle having a dispensing orifice at a distal end of the body, and assist air is supplied to a location adjacent the dispensing orifice. A seat is disposed in the nozzle around the dispensing orifice, and an end of a needle is movable into contact with and through the seat to terminate a flow of the coating material through the dispensing orifice and eliminate any coating material flow path downstream of the seat. A needle guide is used to laterally support the needle above the nozzle. The distal end of a nozzle is the distal end of the applicator and is exposed for cleaning.

    摘要翻译： 用于将保形涂层材料分配到基底上的涂布器。 施用器具有主体，其具有在主体的远端处具有分配孔的喷嘴，并且辅助空气被供应到与分配孔相邻的位置。 一个座位设置在分配孔周围的喷嘴中，并且针的一端可移动地与座接触并穿过座，以终止涂层材料通过分配孔的流动并消除座位下游的任何涂层材料流动路径 。 使用针导向器横向地支撑喷嘴上方的针。 喷嘴的远端是施加器的远端，并被暴露以进行清洁。

    Scalable approach to large scale queuing through dynamic resource allocation
    9.
    发明申请
    Scalable approach to large scale queuing through dynamic resource allocation 有权
    通过动态资源分配进行大规模排队的可扩展方法

    公开(公告)号：US20050047338A1

    公开(公告)日：2005-03-03

    申请号：US10648624

    申请日：2003-08-25

    申请人： Robert Hoffman ,  Raymond Kloth ,  Alessandro Fulli

    发明人： Robert Hoffman ,  Raymond Kloth ,  Alessandro Fulli

    IPC分类号： H04L12/56 ,  G01R31/08 ,  H04L12/28

    CPC分类号： H04L49/9047 ,  H04L47/6215 ,  H04L49/30 ,  H04L49/3045 ,  H04L49/90

    摘要： Methods and devices are provided for the efficient allocation and deletion of virtual output queues. According to some implementations, incoming packets are classified according to a queue in which the packet (or classification information for the packet) will be stored, e.g., according to a “Q” value. For example, a Q value may be a Q number defined as {Egress port number ∥∥ Priority number∥∥ Ingress port number}. Only a single physical queue is allocated for each classification. When a physical queue is empty, the physical queue is preferably de-allocated and added to a “free list” of available physical queues. Accordingly, the total number of allocated physical queues preferably does not exceed the total number of classified packets. Because the input buffering requirements of Fibre Channel (“FC”) and other protocols place limitations on the number of incoming packets, the dynamic allocation methods of the present invention result in a sparse allocation of physical queues.

    摘要翻译： 提供了方法和设备，用于有效分配和删除虚拟输出队列。 根据一些实现方式，输入分组根据其中将存储分组（或分组的分类信息）的队列进行分类，例如根据“Q”值。 例如，Q值可以是定义为{出口端口号||优先级号||入口端口号}的Q号。 每个分类只分配一个物理队列。 当物理队列为空时，物理队列优选地被去分配并被添加到可用物理队列的“空闲列表”中。 因此，分配的物理队列的总数优选地不超过分类分组的总数。 由于光纤通道（“FC”）和其他协议的输入缓冲要求对输入数据包数量的限制，本发明的动态分配方法导致物理队列的稀疏分配。

    Microscopy systems with rectangular illumination particularly adapted for viewing transparent objects
    10.
    发明授权
    Microscopy systems with rectangular illumination particularly adapted for viewing transparent objects 失效
    具有矩形照明的显微镜系统特别适用于观察透明物体

    公开(公告)号：US4200354A

    公开(公告)日：1980-04-29

    申请号：US898647

    申请日：1978-04-21

    申请人： Robert Hoffman

    发明人： Robert Hoffman

    IPC分类号： G02B21/14

    CPC分类号： G02B21/14

    摘要： A modulation contrast microscope employs a closely wound lamp filament of a rectangular configuration as an illuminating source. The image of the filament is registered on a Fourier plane to which plane a modulator is located which serves to render phase gradients in phase objects visible by functioning to provide light amplitude differences in accordance with modifying the amplitude of the light beam relatively about a given region in both a greater and lesser intensity.

    摘要翻译： 调制对比显微镜使用矩形配置的紧密缠绕的灯丝作为照明源。 灯丝的图像被登记在傅立叶平面上，调制器位于该平面上，该平面用于使相位物体中的相位梯度可见，其功能是提供相对于给定区域的光束的振幅的光振幅差 在更大和更小的强度。