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公开(公告)号:US20090042281A1
公开(公告)日:2009-02-12
申请号:US11841880
申请日:2007-08-20
申请人: Jim Yuchen Chang , James Kevin Mainquist , Robert Charles Downs , Jeremy Scot Caldwell , Frederick J. King
发明人: Jim Yuchen Chang , James Kevin Mainquist , Robert Charles Downs , Jeremy Scot Caldwell , Frederick J. King
IPC分类号: C12M1/34
CPC分类号: B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00326 , B01J2219/00328 , B01J2219/00387 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00722 , B01J2219/00734 , B01J2219/00743 , C12M23/12 , C12M23/50 , C12M41/48 , C40B60/06 , G01N35/0099
摘要: High throughput compound profiling systems, and related devices and sub-systems that can be used to perform various compound profiling processes are provided. These systems typically include work perimeters that are organized for optimum efficiency and processing accuracy. Further, these systems are readily adaptable for performing a wide array of assays, as many different system components are easily incorporated or interchangeable in a particular system. System components that are provided by the invention include cell culture dissociators, which can be used, e.g., to effect cell wetting, dissociation, and/or agitation applications. In some embodiments, these cell culture dissociators are included as components of automated cell culture passaging stations. Dispensing devices that permit on-the-fly fluid temperature regulation are also provided. In addition, various compound profiling methods, cell dissociation methods, uniform cell concentration dispensing methods, among other processes, are also provided.
摘要翻译: 提供了高吞吐量复合分析系统以及可用于执行各种复合分析过程的相关设备和子系统。 这些系统通常包括为最佳效率和处理精度而组织的工作周长。 此外,这些系统容易适用于执行广泛的测定,因为许多不同的系统组件在特定系统中容易地并入或可互换。 本发明提供的系统组分包括细胞培养解离器,其可用于例如实现细胞润湿,解离和/或搅拌应用。 在一些实施方案中,这些细胞培养物解离子被包括作为自动细胞培养传代站的组分。 还提供允许即时流体温度调节的分配装置。 此外,还提供了各种复合成型方法,细胞解离方法,均匀的细胞浓度分配方法以及其它方法。
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公开(公告)号:US20080253927A1
公开(公告)日:2008-10-16
申请号:US12144573
申请日:2008-06-23
申请人: Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
发明人: Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
IPC分类号: G01N35/10
CPC分类号: B01L9/523 , B01J2219/00587 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/0072 , B01L2300/0829 , B01L2300/0893 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1074 , G01N2015/1006 , G01N2035/00306 , G01N2035/00366 , G01N2035/0405 , G01N2035/0427 , G01N2035/1037 , G01N2500/10 , G01N2500/20 , Y02A50/58 , Y10T436/114165 , Y10T436/2575
摘要: The present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.
摘要翻译: 本发明提供一种使用样品保持器进行高通量处理的系统和方法。 该系统具有多个工作周边,其中旋转机器人优选地与每个工作周界相关联。 在相邻工作周边之间提供至少一个传送站区域,以便将样品架从一个工作周边机器人传送到另一个区域。 每个工作周界通常包括多个定义的站位置,其中每个站位置定位成由与该区域相关联的机器人可访问。 此外,每个站位置通常被配置为接收诸如自动化仪器或保持嵌套之类的设备。 设备组件根据特定的应用要求安排在选定的站位置,以提供灵活,稳健,可靠,准确的高吞吐量处理系统。
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公开(公告)号:US07390458B2
公开(公告)日:2008-06-24
申请号:US09981313
申请日:2001-10-15
申请人: Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
发明人: Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
CPC分类号: B01L9/523 , B01J2219/00587 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/0072 , B01L2300/0829 , B01L2300/0893 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1074 , G01N2015/1006 , G01N2035/00306 , G01N2035/00366 , G01N2035/0405 , G01N2035/0427 , G01N2035/1037 , G01N2500/10 , G01N2500/20 , Y02A50/58 , Y10T436/114165 , Y10T436/2575
摘要: Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.
摘要翻译: 简而言之,本发明提供了一种使用样品保持器进行高通量处理的系统和方法。 该系统具有多个工作周边,其中旋转机器人优选地与每个工作周界相关联。 在相邻工作周边之间提供至少一个传送站区域,以便将样品架从一个工作周边机器人传送到另一个区域。 每个工作周界通常包括多个定义的站位置,其中每个站位置定位成由与该区域相关联的机器人可访问。 此外,每个站位置通常被配置为接收诸如自动化仪器或保持嵌套之类的设备。 设备组件根据特定的应用要求安排在选定的站位置,以提供灵活,稳健,可靠,准确的高吞吐量处理系统。
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公开(公告)号:US06534014B1
公开(公告)日:2003-03-18
申请号:US09569325
申请日:2000-05-11
申请人: James Kevin Mainquist , Robert Charles Downs , Mark Richard Weselak , Andrew J. Meyer , Kristina Marie Burow , Daniel G. Sipes , Jeremy Caldwell
发明人: James Kevin Mainquist , Robert Charles Downs , Mark Richard Weselak , Andrew J. Meyer , Kristina Marie Burow , Daniel G. Sipes , Jeremy Caldwell
IPC分类号: C12M122
CPC分类号: B01L3/50853
摘要: The specimen plate lid is generally a block, with a cover portion and a side portion. An alignment protrusion extends from the side portion and cooperates with an alignment member of the specimen plate to assist in manually or roboticly guiding the lid onto the specimen plate. An underside surface of the cover has a sealing perimeter for receiving a seal constructed from a compliant material, and shaped to cooperate with a complimentary sealing surface on the specimen plate. The lid is weighted so that when the lid is aligned and positioned on the specimen plate, the weight of the lid provides a gravitational force to sufficiently compress the seal against the sealing surface on the specimen plate. Accordingly, the lid is sufficiently sealed to the specimen plate to avoid contamination and impermissible drying.
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公开(公告)号:US06932557B2
公开(公告)日:2005-08-23
申请号:US10620324
申请日:2003-07-14
CPC分类号: B25J15/0253 , B25J17/0208 , B65G47/90 , B65H29/02 , B65H2555/31 , Y10S294/902 , Y10S414/136 , Y10S414/141
摘要: The present invention provides grasping mechanisms, gripper apparatus/systems, and related methods. Grasping mechanisms that include stops, support surfaces, and height adjusting surfaces to determine three translational axis positions of a grasped object are provided. In addition, grasping mechanisms that are resiliently coupled to other gripper apparatus components are also provided.
摘要翻译: 本发明提供了抓握机构,夹持装置/系统及相关方法。 提供了包括停止,支撑表面和高度调节表面以确定被抓取物体的三个平移轴位置的抓握机构。 此外,还提供了弹性耦合到其他夹持器装置部件的抓握机构。
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公开(公告)号:US06635441B2
公开(公告)日:2003-10-21
申请号:US09780591
申请日:2001-02-08
申请人: Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Daniel T. McMullan , Andrew J. Meyer , Marc Nasoff
发明人: Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Daniel T. McMullan , Andrew J. Meyer , Marc Nasoff
IPC分类号: C12N300
CPC分类号: C12M41/18 , B01J2219/00283 , B01J2219/00308 , B01J2219/00418 , B01J2219/00493 , B01J2219/00495 , B01J2219/00585 , B01J2219/0072 , B01J2219/0074 , B01L3/0289 , B01L3/5085 , C12M23/08 , C12M23/40 , C12M23/42 , C12M23/48 , C12M23/58 , C12M29/00 , C40B60/14 , Y10S435/802 , Y10S435/808 , Y10S435/813 , Y10S435/818
摘要: A fermentation apparatus is constructed to produce a known and repeatable amount of unpoisoned fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an array of sample vessels arranged in a container frame. The container frame is configured to hold the sample vessels during fermentation and to transport the vessel array to or from another processing station. Corresponding to the number of sample vessels in the sample vessel array, a cannula array is configured such that each cannula may be placed inside a sample vessel. The cannula array is attached to a gas distributor that delivers oxygen and/or one or more other gases from a gas source through the cannula into the sample vessel. Because the fermentation volume for each individual sample vessel is smaller than a bulk fermentation apparatus, the fermentation product yields are more predictable and cell growth rates may be more effectively optimized.
摘要翻译: 构建发酵设备以产生使用多个发酵容器的已知和可重复量的未发酵的发酵产物。 为了促进与其他产品加工步骤相容的进一步加工,发酵设备具有布置在容器框架中的样品容器阵列。 容器框架构造成在发酵期间保持样品容器并将容器阵列运送到另一个处理站或从另一个处理站运送。 对应于样品容器阵列中的样品容器的数量,套管阵列被配置为使得每个插管可以放置在样品容器内。 套管阵列连接到气体分配器,气体分配器将氧气和/或一种或多种其它气体从气体源通过套管输送到样品容器中。 因为每个单个样品容器的发酵体积小于本体发酵装置,所以发酵产物产量更可预测,并且可以更有效地优化细胞生长速率。
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公开(公告)号:US06488610B2
公开(公告)日:2002-12-03
申请号:US09735665
申请日:2000-12-14
IPC分类号: F16H6126
CPC分类号: F16H61/12 , F16H61/0206 , F16H61/686 , F16H2059/683 , F16H2061/1204 , F16H2061/122 , F16H2061/1232 , F16H2061/1268 , F16H2061/1292 , F16H2306/00 , Y10T477/693635
摘要: An electro-hydraulic control system for an automatic transmission comprises a manual selector valve for operator direction of line pressure fluid to a drive passage when drive is selected or to a reverse passage when reverse is selected. A drive/reverse passage connects the drive passage and the reverse passage. A first check ball is disposed between the drive passage and the drive/reverse passage and a second check ball is disposed between the reverse passage and the drive/reverse passage wherein the check balls operate to pressurize the drive/reverse passage when either drive or reverse is selected. The system further includes six fluid operated selectively engageable friction devices, three friction device actuators each associated with one of the six friction devices, in parallel relation and electronically actuated to direct fluid from the drive passage to the respective friction device, and a two-friction device actuator operative to direct fluid from the drive/reverse passage to one of two friction devices. Three pressure-operated feed protection valves are disposed intermediate of two of the actuators and their two friction devices, which operate to prevent flow to the two downstream friction devices.
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公开(公告)号:US07422411B2
公开(公告)日:2008-09-09
申请号:US11516826
申请日:2006-09-06
IPC分类号: B25J15/00
CPC分类号: B25J15/0253 , B25J17/0208 , B65G47/90 , B65H29/02 , B65H2555/31 , Y10S294/902 , Y10S414/136 , Y10S414/141
摘要: The present invention provides grasping mechanisms, gripper apparatus/systems, and related methods. Grasping mechanisms that include stops, support surfaces, and height adjusting surfaces to determine three translational axis positions of a grasped object are provided. In addition, grasping mechanisms that are resiliently coupled to other gripper apparatus components are also provided.
摘要翻译: 本发明提供了抓握机构,夹持装置/系统及相关方法。 提供了包括停止,支撑表面和高度调节表面以确定被抓取物体的三个平移轴位置的抓握机构。 此外,还提供了弹性耦合到其他夹持器装置部件的抓握机构。
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公开(公告)号:US06723555B2
公开(公告)日:2004-04-20
申请号:US10071842
申请日:2002-02-08
申请人: Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Daniel Terence McMullan , Andrew J. Meyer , Marc Nasoff
发明人: Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Daniel Terence McMullan , Andrew J. Meyer , Marc Nasoff
IPC分类号: C12M100
CPC分类号: C12M41/18 , B01J2219/00283 , B01J2219/00308 , B01J2219/00418 , B01J2219/00493 , B01J2219/00495 , B01J2219/00585 , B01J2219/0072 , B01J2219/0074 , B01L3/0289 , B01L3/5085 , C12M23/08 , C12M23/40 , C12M23/42 , C12M23/48 , C12M23/58 , C12M29/00 , C40B60/14 , Y10S435/802 , Y10S435/808 , Y10S435/813 , Y10S435/818
摘要: A fermentation apparatus is constructed to produce a known and repeatable amount of untainted fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an array of sample vessels arranged in a container frame. The container frame is configured to hold the sample vessels during fermentation and to transport the vessel array to or from another processing station. Corresponding to the number of sample vessels in the sample vessel array, a cannula array is configured such that each cannula may be placed inside a sample vessel. The cannula array is attached to a gas distributor that delivers oxygen and/or one or more other gases from a gas source through the cannula into the sample vessel. Because the fermentation volume for each individual sample vessel is smaller than a bulk fermentation apparatus, the fermentation product yields are predictable and cell growth rates can be effectively optimized.
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公开(公告)号:US06443277B1
公开(公告)日:2002-09-03
申请号:US09661774
申请日:2000-09-14
申请人: Joel A. Taylor , David Allen Blenc , Robert Charles Downs , James Kevin Mainquist , Goro Tamai , Kyle Kenneth Kinsey
发明人: Joel A. Taylor , David Allen Blenc , Robert Charles Downs , James Kevin Mainquist , Goro Tamai , Kyle Kenneth Kinsey
IPC分类号: B60K4122
CPC分类号: F16H61/0267 , B60K6/48 , B60W10/02 , B60W10/10 , B60W20/00 , F16H61/0286 , Y02T10/6221 , Y10S903/945 , Y10S903/946
摘要: A first clutch circuit for an automatic transmission in a hybrid drive vehicle comprises an apply line extending from a manual valve to a clutch, with a check ball disposed in the apply line operable to move out of the apply line upon upstream fluid pressure, and an exhaust line extending from the apply line, downstream of the check ball, to an exhaust valve. A driver-triggered valve actuating means operates to close the exhaust valve when the driver selects drive with a driver shift lever and to open the exhaust valve when the driver shifts out of drive thereby releasing the clutch.
摘要翻译: 用于混合动力车辆中的自动变速器的第一离合器回路包括从手动阀延伸到离合器的施加线,设置在施加线中的止回球可操作以在上游流体压力下移出施加线,并且 排气管线从检查球下游的施加管线延伸到排气阀。 当驾驶员用驾驶员换档杆选择驾驶并且当驾驶员离开驱动器时打开排气阀从而释放离合器,驾驶员触发阀致动装置用于关闭排气门。
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