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    SUBSTANCE DETERMINING APPARATUS
    1.
    发明申请
    SUBSTANCE DETERMINING APPARATUS 审中-公开
    物质确定装置

    公开(公告)号：US20120252033A1

    公开(公告)日：2012-10-04

    申请号：US13515853

    申请日：2010-12-10

    申请人： Joannes Baptist Adrianus Dionisius Van Zon ,  Toon Hendrik Evers ,  Maatje Koets

    发明人： Joannes Baptist Adrianus Dionisius Van Zon ,  Toon Hendrik Evers ,  Maatje Koets

    IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N30/00

    CPC分类号： G01N21/552 ,  G01N33/54373

    摘要： The invention relates to a substance determining apparatus and method for determining a substance within a fluid. Particles attach to the substance and bind to a binding surface (30), wherein a particle release curve being indicative of a release of bound particles from the binding surface (30) is determined, and a part of the particle release curve caused by particles bound to the binding surface via a predefined kind of binding is determined based on the temporal behaviour of the particle release curve. The substance within the fluid is determined based on the part of the particle release curve. The substance can therefore be determined based on particles which are bound to the binding surface via a certain kind of binding, i.e. other kinds of binding substantially do not affect the determination of the substance, thereby improving the accuracy of determining the substance.

    摘要翻译： 本发明涉及一种用于确定流体内的物质的物质确定装置和方法。 颗粒附着于物质并结合至结合表面（30），其中确定指示结合颗粒从结合表面（30）释放的颗粒释放曲线，并且由颗粒结合引起的部分颗粒释放曲线 基于粒子释放曲线的时间行为来确定经由预定类型的结合的结合表面。 基于颗粒释放曲线的部分确定流体内的物质。 因此，物质可以基于通过某种结合结合到结合表面的颗粒来确定，即其它种类的结合基本上不影响物质的测定，从而提高了确定物质的准确性。

    DETECTION OF MAGNETIC PARTICLES AND THEIR CLUSTERING
    4.
    发明申请
    DETECTION OF MAGNETIC PARTICLES AND THEIR CLUSTERING 审中-公开
    检测磁性颗粒及其聚集

    公开(公告)号：US20130088221A1

    公开(公告)日：2013-04-11

    申请号：US13705000

    申请日：2010-11-30

    申请人： Joannes Baptist Adrianus Dionisius Van Zon ,  Mkhail Mikhaylovich Ovsyanko ,  Toon Hendrik Evers ,  Mara Johanna Jacoba Sijbers

    发明人： Joannes Baptist Adrianus Dionisius Van Zon ,  Mkhail Mikhaylovich Ovsyanko ,  Toon Hendrik Evers ,  Mara Johanna Jacoba Sijbers

    IPC分类号： G01N27/72

    CPC分类号： G01N27/72 ,  B01L3/502761 ,  B82Y25/00 ,  G01N15/06 ,  G01N15/0656 ,  G01N2015/0693 ,  G01R33/1276 ,  H01F1/0036

    摘要： The invention relates to a method and associated apparatuses (100) for the detection of magnetic particles (MP) in a sample chamber (111). The method comprises the determination of a “particle-parameter” that is related to the amount of magnetic particles (MP) in a first detection region (P, C), the determination of a “cluster-parameter” that is related to the degree of clustering of magnetic particles (MP) in a second detection region (P, C), and the evaluation of the particle-parameter based on the cluster-parameter. Various apparatuses are disclosed that can be applied in said method. In one apparatus (100), a magnetic field (B) is generated in the sample chamber (111) in such a way that it has different inclinations in a first and second field region (P, C) and/or that it is oblique to the binding surface (112) in at least one field region. Magnetic particles (MP) are then detected in said first and second field region and/or in said at least one field region before and after a permanent switch-off of the inclined magnetic field. The resulting detection signals are related to each other to determine a cluster-parameter. In other embodiments, a cluster-parameter may be determined from light transmission measurements during the application of a magnetic field that is switched on and off.

    摘要翻译： 本发明涉及一种用于检测样品室（111）中的磁性颗粒（MP）的方法和相关装置（100）。 该方法包括确定与第一检测区域（P，C）中的磁性粒子（MP）的量相关的粒子参数，确定与磁性聚类程度相关的聚类参数 颗粒（MP）在第二检测区域（P，C）中，以及基于聚类参数的粒子参数的评估。 公开了可以应用于所述方法的各种装置。 在一个装置（100）中，在样品室（111）中产生磁场（B），使得其在第一和第二场区域（P，C）中具有不同的倾斜度和/或倾斜 到达至少一个场区域中的结合表面（112）。 然后在永久关闭倾斜磁场之前和之后，在所述第一和第二场区和/或所述至少一个场区中检测磁性颗粒（MP）。 所得到的检测信号彼此相关，以确定簇参数。 在其他实施例中，可以在施加接通和关断的磁场期间的光透射测量来确定簇参数。