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    NUCLEIC ACID PROBE-IMMOBILIZED SUBSTRATE AND METHOD OF DETECTING THE PRESENCE OF TARGET NUCLEIC ACID BY USING THE SAME
    1.
    发明申请
    NUCLEIC ACID PROBE-IMMOBILIZED SUBSTRATE AND METHOD OF DETECTING THE PRESENCE OF TARGET NUCLEIC ACID BY USING THE SAME 审中-公开
    核酸探针固定基质及其检测目标核酸存在的方法

    公开(公告)号：US20090075275A1

    公开(公告)日：2009-03-19

    申请号：US12142230

    申请日：2008-06-19

    申请人： Masayoshi Takahashi ,  Jun Okada ,  Koji Hashimoto

    发明人： Masayoshi Takahashi ,  Jun Okada ,  Koji Hashimoto

    IPC分类号： C12Q1/68 ,  G01N33/50

    CPC分类号： C12Q1/6837 ,  Y10T436/143333 ,  C12Q2525/197 ,  C12Q2525/161 ,  C12Q2563/107 ,  C12Q2563/113

    摘要： The invention provides a nucleic acid probe-immobilized substrate comprising a substrate and a nucleic acid probe containing a nucleotide sequence complementary to a target sequence and immobilized via a spacer onto the substrate, wherein upon hybridization, with the nucleic acid probe, of a target nucleic acid partially containing the target sequence, the spacer satisfies the relationship: X≧Y wherein X is the length of the spacer and Y is the length of the target nucleic acid ranging from the end of the hybridized site at the side of the substrate to the end of the target nucleic acid at the side of the substrate.

    摘要翻译： 本发明提供了一种固定有核酸探针的底物，其包含底物和含有与靶序列互补的核苷酸序列并通过间隔基固定在底物上的核酸探针，其中在与核酸探针杂交时，靶核酸 部分含有目标序列的酸，间隔物满足以下关系：<？in-line-formula description =“In-line formula”end =“lead”？> X> = Y <？in-line-formula description =“In 线式“end =”tail“？>其中X是间隔物的长度，Y是靶核酸的范围从底物侧面的杂交位点到靶核酸末端的长度 酸在基材的一侧。

    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method
    2.
    发明申请
    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method 有权
    碱基序列检测电极，碱基序列检测装置和碱基序列检测方法

    公开(公告)号：US20070007148A1

    公开(公告)日：2007-01-11

    申请号：US11452370

    申请日：2006-06-14

    申请人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    发明人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    IPC分类号： G01N27/26

    CPC分类号： C12Q1/6825 ,  C12Q2563/173 ,  C12Q2549/125

    摘要： A conductive detecting electrode (2), first blocking molecules (21) formed so as to cover a surface of the detecting electrode (2), the first blocking molecules decreasing adsorption of an intercalating agent to the surface of the detecting electrode (2), a target-complementary probe (23) immobilized to the detecting electrode (2) via a spacer member (22) comprising straight chain organic molecules, the target-complementary probe including a base sequence complementary to a target base sequence which is an object of detection, a conductive comparison electrode (3), and second blocking molecules (31) formed so as to cover a surface of the comparison electrode (3), the second blocking molecules decreasing adsorption of an intercalating agent to the surface of the comparison electrode (3), are provided.

    摘要翻译： 导电检测电极（2），形成为覆盖检测电极（2）的表面的第一阻挡分子（21），第一阻挡分子减少插入剂吸附到检测电极（2）的表面， 通过包含直链有机分子的间隔构件（22）固定在检测电极（2）上的目标互补探针（23），靶互补探针包括与作为检测对象的目标碱基序列互补的碱基序列 ，导电比较电极（3）和形成为覆盖比较电极（3）的表面的第二阻挡分子（31），第二阻断分子减少插入剂吸附到比较电极（3）的表面 ）。

    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method
    3.
    发明授权
    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method 有权
    碱基序列检测电极，碱基序列检测装置和碱基序列检测方法

    公开(公告)号：US07718048B2

    公开(公告)日：2010-05-18

    申请号：US11452370

    申请日：2006-06-14

    申请人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    发明人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    IPC分类号： G01N27/327

    CPC分类号： C12Q1/6825 ,  C12Q2563/173 ,  C12Q2549/125

    摘要： A conductive detecting electrode (2), first blocking molecules (21) formed so as to cover a surface of the detecting electrode (2), the first blocking molecules decreasing adsorption of an intercalating agent to the surface of the detecting electrode (2), a target-complementary probe (23) immobilized to the detecting electrode (2) via a spacer member (22) comprising straight chain organic molecules, the target-complementary probe including a base sequence complementary to a target base sequence which is an object of detection, a conductive comparison electrode (3), and second blocking molecules (31) formed so as to cover a surface of the comparison electrode (3), the second blocking molecules decreasing adsorption of an intercalating agent to the surface of the comparison electrode (3), are provided.

    摘要翻译： 导电检测电极（2），形成为覆盖检测电极（2）的表面的第一阻挡分子（21），第一阻挡分子减少插入剂吸附到检测电极（2）的表面， 通过包含直链有机分子的间隔构件（22）固定在检测电极（2）上的目标互补探针（23），靶互补探针包括与作为检测对象的目标碱基序列互补的碱基序列 ，导电比较电极（3）和形成为覆盖比较电极（3）的表面的第二阻挡分子（31），第二阻断分子减少插入剂吸附到比较电极（3）的表面 ）。

    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method
    4.
    发明授权
    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method 有权
    碱基序列检测电极，碱基序列检测装置和碱基序列检测方法

    公开(公告)号：US07097751B2

    公开(公告)日：2006-08-29

    申请号：US10239175

    申请日：2002-08-28

    申请人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    发明人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    IPC分类号： G01N27/327 ,  C12Q1/68

    CPC分类号： C12Q1/6825 ,  C12Q2563/173 ,  C12Q2549/125

    摘要： A conductive detecting electrode (2), first blocking molecules (21) formed so as to cover a surface of the detecting electrode (2), the first blocking molecules decreasing adsorption of an intercalating agent to the surface of the detecting electrode (2), a target-complementary probe (23) immobilized to the detecting electrode (2) via a spacer member (22) comprising straight chain organic molecules, the target-complementary probe including a base sequence complementary to a target base sequence which is an object of detection, a conductive comparison electrode (3), and second blocking molecules (31) formed so as to cover a surface of the comparison electrode (3), the second blocking molecules decreasing adsorption of an intercalating agent to the surface of the comparison electrode (3), are provided.

    摘要翻译： 导电检测电极（2），形成为覆盖检测电极（2）的表面的第一阻挡分子（21），第一阻挡分子减少插入剂吸附到检测电极（2）的表面， 通过包含直链有机分子的间隔构件（22）固定在检测电极（2）上的目标互补探针（23），靶互补探针包括与作为检测对象的目标碱基序列互补的碱基序列 ，导电比较电极（3）和形成为覆盖比较电极（3）的表面的第二阻挡分子（31），第二阻断分子减少插入剂吸附到比较电极（3）的表面 ）。

    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method
    6.
    发明申请
    Base sequence detecting electrode, base sequence detecting device and base sequence detecting method 有权
    碱基序列检测电极，碱基序列检测装置和碱基序列检测方法

    公开(公告)号：US20050089447A1

    公开(公告)日：2005-04-28

    申请号：US10239175

    申请日：2002-08-28

    申请人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    发明人： Jun Okada ,  Koji Hashimoto ,  Masayoshi Takahashi

    IPC分类号： G01N33/483 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/327 ,  G01N27/416 ,  G01N33/53 ,  G01N37/00 ,  G01N27/00

    CPC分类号： C12Q1/6825 ,  C12Q2563/173 ,  C12Q2549/125

    摘要： A conductive detecting electrode (2), first blocking molecules (21) formed so as to cover a surface of the detecting electrode (2), the first blocking molecules decreasing adsorption of an intercalating agent to the surface of the detecting electrode (2), a target-complementary probe (23) immobilized to the detecting electrode (2) via a spacer member (22) comprising straight chain organic molecules, the target-complementary probe including a base sequence complementary to a target base sequence which is an object of detection, a conductive comparison electrode (3), and second blocking molecules (31) formed so as to cover a surface of the comparison electrode (3), the second blocking molecules decreasing adsorption of an intercalating agent to the surface of the comparison electrode (3), are provided.

    摘要翻译： 导电检测电极（2），形成为覆盖检测电极（2）的表面的第一阻挡分子（21），第一阻挡分子减少插入剂吸附到检测电极（2）的表面， 通过包含直链有机分子的间隔构件（22）固定在检测电极（2）上的目标互补探针（23），靶互补探针包括与作为检测对象的目标碱基序列互补的碱基序列 ，导电比较电极（3）和形成为覆盖比较电极（3）的表面的第二阻挡分子（31），第二阻断分子减少插入剂吸附到比较电极（3）的表面 ）。