公开(公告)号：US4158545A

公开(公告)日：1979-06-19

申请号：US834902

申请日：1977-09-20

申请人： Katsuji Yamashita ,  Hiroshi Umetsu ,  Kazuyoshi Heguri ,  Kasumi Yoshida

发明人： Katsuji Yamashita ,  Hiroshi Umetsu ,  Kazuyoshi Heguri ,  Kasumi Yoshida

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N35/02 ,  G01N1/14 ,  G01N1/18

CPC分类号： G01N35/021 ,  Y10T436/113332 ,  Y10T436/115831

摘要： In an automatic chemical analyzing method and apparatus in which a plurality of samples each added with a reagent are discretely transported through a reaction line and subjected to a reaction during the transportation for optical measurement to generate measured signals and to process them, the samples to be analyzed are grouped into a plurality of sample groups each including a plurality of samples which are to be measured with respect to the same test items, which are previously stored for each sample group in a memory of a central control unit. The samples are divided by a number corresponding to the number of test items and successively fed to the reaction line one by one in sample groups, and, at the time of change of the sample group receiving the analysis, test items corresponding to a new sample group are read from the memory to carry out a chemical analysis for the samples in each sample group according to the read test items.

摘要翻译： 在自动化学分析方法和装置中，每个加入试剂的多个样品离散地通过反应管线输送并在光学测量运输期间进行反应以产生测量信号并进行处理，样品为 分析被分组成多个采样组，每个样本组包括相对于中央控制单元的存储器中的每个样本组预先存储的相同测试项目要测量的多个样本。 将样品除以与测试项目数相对应的数字，并在样品组中逐个进料到反应线，并且在接收分析的样品组的变化时，对应于新样品的测试项目 从存储器读取组，根据读取的测试项目对每个样品组中的样品进行化学分析。

公开(公告)号：US4291986A

公开(公告)日：1981-09-29

申请号：US62115

申请日：1979-07-30

申请人： Takehide Satou ,  Kasumi Yoshida ,  Hisayuki Sagusa ,  Osamu Ohno ,  Tetuaki Abe

发明人： Takehide Satou ,  Kasumi Yoshida ,  Hisayuki Sagusa ,  Osamu Ohno ,  Tetuaki Abe

IPC分类号： G01N21/11 ,  G01N21/25 ,  G01N21/75 ,  G01N35/00 ,  G01N35/02 ,  G01N35/08 ,  G01N35/10 ,  G01N21/85

CPC分类号： G01N21/253 ,  G01N35/021 ,  G01N2035/00435 ,  G01N35/1079

摘要： A serum and a reagent are supplied into a reaction tube to prepare a reactive solution or a sample solution which is sucked up at a predetermined position into one of a plurality of flow cells. The flow cells are mounted on a thermostatic block to be heated to a predetermined temperature and alternatively supplied with the sample solution. After a sample solution has been introduced from a specified reaction tube into one of the flow cells and heated to the predetermined temperature, the sample solution in the one flow cell is irradiated with light to measure changes in absorbance of the sample solution for a predetermined time. During a period when the absorbance changes of the sample solution in one flow cell is measured, another sample solution is introduced from another reaction tube into another flow cell and heated to the predetermined temperature. Immediately after the measurement of the absorbance changes of the sample solution in the one flow cell has been completed, the other flow cell is irradiated with light to measure the changes in absorbance of the sample solution in the other flow cell. Thereafter, one and the other flow cells are alternately supplied with a sample solution to successively measure the absorbance changes. Thus, a waiting time for stabilizing the temperature of the sample solution introduced into the flow cell can be actually dispensed with, and therefore effective measurement can be made.

摘要翻译： 将血清和试剂供给到反应管中以制备在预定位置吸入多个流动池中的一个流动池中的反应性溶液或样品溶液。 将流动池安装在恒温块上以加热到预定温度，并交替地供应样品溶液。 在将样品溶液从指定的反应管引入其中一个流通池中并加热到预定温度后，用一定流量池中的样品溶液照射样品溶液的吸光度变化达预定时间 。 在测量一个流动池中的样品溶液的吸光度变化的期间，将另一个样品溶液从另一个反应管引入另一个流通池并加热至预定温度。 在一个流通池中的样品溶液的吸光度变化的测量完成之后，立即用光照射另一个流动池，以测量另一个流动池中的样品溶液的吸光度变化。 此后，将一个和另一个流动池交替地供应样品溶液以连续测量吸光度变化。 因此，实际上可以省去用于稳定引入流通池的样品溶液的温度的等待时间，因此可以进行有效的测量。

公开(公告)号：US4260580A

公开(公告)日：1981-04-07

申请号：US942142

申请日：1978-09-14

申请人： Isao Sindo ,  Yoshio Matsuoka ,  Kasumi Yoshida

发明人： Isao Sindo ,  Yoshio Matsuoka ,  Kasumi Yoshida

IPC分类号： G01N27/416 ,  G01N35/00 ,  G01N35/02 ,  G01N1/14

CPC分类号： G01N35/0095 ,  G01N35/021

摘要： Sample cups containing serum are removably loaded in a plurality of annular holders flexibly connected to make up a slidable chain which is moved through a limited path and passes a sampling position. Ion-selecting electrodes and a reference electrode are slightly spaced from the sampling position. A predetermined amount of serum in the sample cup that has arrived at the sampling position is distributed to a measurement tank. The electromotive force based on the ion to be measured is detected, and the ion concentration is printed out on a printer on the basis of the detection result. Normally, samples sequentially arriving at the sampling position are distributed to the measurement tank for continual analysis. Upon receipt of an emergency sample, an interruption switch on the operation panel is depressed for transmitting an interruption measurement command to a control section. After completion of the ongoing measurement of an ordinary sample, the chain motion is stopped with the particular sample kept at the sampling position, which sample is replaced manually by the emergency sample. A wide open sapce is provided around the sampling position to facilitate sample cup removal from and insertion into the holder. Depressing the start switch with the emergency sample at the sampling position, only the emergency sample is analyzed, after which the analyzer is stopped again. The interruption measurement command is cancelled by the interruption switch and the start switch is turned on, thus restarting continual measurement of ordinary samples.

摘要翻译： 含有血清的样品杯可移除地装载在多个环形夹持器中，所述多个环形夹持器柔性地连接以构成滑动链条，该链条通过有限的路径移动并通过取样位置。 离子选择电极和参比电极与采样位置稍微间隔开。 已经到达采样位置的样品杯中的预定量的血清被分配到测量罐。 检测基于待测离子的电动势，并且根据检测结果将离子浓度打印在打印机上。 通常，连续到达采样位置的样品被分配到测量槽以进行连续分析。 在接收到紧急样品时，操作面板上的中断开关被按下以将中断测量命令发送到控制部分。 在完成普通样品的持续测量之后，链条运动停止，特定样品保持在采样位置，该样品由紧急样品手动替换。 在采样位置周围提供宽敞的开口，以方便样品杯从支架中移出并插入支架。 在采样位置用紧急样品按下启动开关，仅分析紧急样品，然后再次停止分析仪。 通过中断开关取消中断测量命令，启动开关打开，重新开始普通样品的连续测量。

公开(公告)号：US5460968A

公开(公告)日：1995-10-24

申请号：US348210

申请日：1994-11-28

申请人： Kasumi Yoshida ,  Isao Shindo ,  Susumu Kai ,  Yutaka Kimura

发明人： Kasumi Yoshida ,  Isao Shindo ,  Susumu Kai ,  Yutaka Kimura

IPC分类号： G01N1/10 ,  G01N21/78 ,  G01N33/52 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/00029 ,  G01N2035/00108 ,  G01N2035/0441 ,  G01N2035/1025 ,  G01N2201/04 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165

摘要： A sample container containing a urine sample is transferred by a sample positioning device to a liquid level sensing position. At this sensing position, the liquid level in the sample container is detected by a level sensor, followed by transfer of the sample container to a dipping position. A liquid level rising member is then inserted into the sample container. While being held by a handling device, a test strip is dipped into the sample in the sample container with the liquid level raised. Thereafter, the test strip is lifted out of the sample container and transferred to a measuring device. Color development in reagent sections on the test strip is measured by a photometer in terms of the reflected light strength. With the present invention, analysis using test strips can be implemented even when the sample volume into the sample container is small.

摘要翻译： 容纳尿样的样品容器通过样品定位装置转移到液位检测位置。 在该检测位置，通过液位传感器检测样品容器中的液位，随后将样品容器转移到浸渍位置。 然后将液位升高构件插入样品容器中。 在被处理装置保持的同时，将测试条浸入样品容器中，液面升高。 此后，将测试条从样品容器中提出并转移到测量装置。 根据反射光强度，通过光度计测定试片上试剂部分的显色性。 通过本发明，即使在样品容器中的样品体积小的情况下也可以实施使用测试条的分析。

公开(公告)号：US5378630A

公开(公告)日：1995-01-03

申请号：US974273

申请日：1992-11-10

申请人： Susumu Kai ,  Isao Shindo ,  Shigeo Mutoh ,  Kasumi Yoshida

发明人： Susumu Kai ,  Isao Shindo ,  Shigeo Mutoh ,  Kasumi Yoshida

IPC分类号： G01N21/78 ,  B65G47/14 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  B65H3/00

CPC分类号： B65G47/1428 ,  G01N35/00029 ,  G01N2035/00455 ,  Y10T436/11

摘要： A test strip automatic supply device has: a cylindrical container 11 provided with a slit 15 which is formed in a side wall thereof so as to contain an elongate test strip; a container-supporting table having, in an upper portion thereof, a semi-cylindrical concave surface provided with an opening 20 which is formed in a middle portion of the concave surface so as to allow a test strip fitted in the slit of the container 11 to fall through and be taken out; and a carrying stage 31 which receives and transports a test strip falling from the slit 15. While the transporting stage 31 is transporting a test strip, an optical detector finds whether the test strip is faced up or down. The device has such a function that a side-reversing mechanism flips it over during transportation if it is face down. An operator only has to put test strips in the container. The tests strips are automatically let out of the container one at a time.

摘要翻译： 试条自动供给装置具有：圆筒形容器11，其设置有狭缝15，狭缝15形成在其侧壁中，以容纳细长的测试条; 容器支撑台在其上部具有设置有开口20的半圆柱形凹面，所述开口20形成在所述凹面的中间部分中，以允许安装在容器11的狭缝中的测试条 通过并被取出; 以及承载台31，其接收并输送从狭缝15落下的试纸。当传送台31运送测试条时，光学检测器检测出试纸是否面朝上或者向下。 该装置具有这样的功能，即如果侧面反转机构面朝下，则在运输期间翻转它。 操作人员必须将测试条放在容器中。 测试条一次自动从容器中排出。

公开(公告)号：US4520108A

公开(公告)日：1985-05-28

申请号：US442671

申请日：1982-11-18

申请人： Kasumi Yoshida ,  Hideo Uchiki ,  Tadafumi Kuroishi

发明人： Kasumi Yoshida ,  Hideo Uchiki ,  Tadafumi Kuroishi

IPC分类号： G01N21/75 ,  G01N35/08 ,  G01N1/18 ,  G01N35/00

CPC分类号： G01N35/085 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

摘要： A continuous flow analyzer of the type which introduces continuously a carrier liquid into a single tubular conduit to form a stable main carrier stream and injects predetermined volumes of reagent liquid and sample liquid in series into the main carrier stream. The analyzer reduces the consumption of the reagent and can form a stable continuous flow.

摘要翻译： 一种连续流量分析仪，其将载体液体连续引入单个管状导管中以形成稳定的主载流，并将预定体积的试剂液体和样品液体串联注入主载流中。 分析仪降低了试剂的消耗，并可形成稳定的连续流。

公开(公告)号：US5804142A

公开(公告)日：1998-09-08

申请号：US756430

申请日：1996-11-26

申请人： Masahito Ito ,  Junkichi Miura ,  Yoshio Fujii ,  Hiroshi Satake ,  Kasumi Yoshida

发明人： Masahito Ito ,  Junkichi Miura ,  Yoshio Fujii ,  Hiroshi Satake ,  Kasumi Yoshida

IPC分类号： G01N30/86 ,  G01N30/62 ,  G01N30/88 ,  G01N30/02

CPC分类号： G01N30/88 ,  G01N2030/626 ,  G01N2030/8804

摘要： A reference sample having a known concentration is injected into a chromatograph system before an unknown sample is analyzed. This is for the purpose of checking the deterioration of system performance or in other words for the purpose of checking system suitability. In the present invention, the chromatographic characteristic of the check sample at the time of deterioration of the system suitability is expected and stored in a memory in advance to be related to factors of deterioration of system suitability. A factor of deterioration is deduced by comparison between the actually analyzed chromatographic characteristic of the check sample and the relational data stored in the memory. A guidance required for removing the factor is displayed. Disclosed are preferred embodiments of a chromatograph system suitable for analyzing catecholamine or glycated hemoglobin.

摘要翻译： 在分析未知样品之前，将具有已知浓度的参考样品注入色谱系统中。 这是为了检查系统性能的恶化，换句话说是为了检查系统适用性。 在本发明中，期望在系统适用性恶化时检查样品的色谱特性，并预先存储在存储器中，以与系统适用性的劣化因素相关。 通过比较检查样品的实际分析色谱特征和存储在存储器中的关系数据，推导出劣化因素。 显示删除因子所需的指导。 公开了适用于分析儿茶酚胺或糖化血红蛋白的色谱系统的优选实施方案。

公开(公告)号：US4827966A

公开(公告)日：1989-05-09

申请号：US151484

申请日：1988-02-02

申请人： Nobuyoshi Takano ,  Yoshio Watanabe ,  Yoshio Taichi ,  Norimi Akimori ,  Kasumi Yoshida

发明人： Nobuyoshi Takano ,  Yoshio Watanabe ,  Yoshio Taichi ,  Norimi Akimori ,  Kasumi Yoshida

IPC分类号： G01N33/49 ,  A61B5/145 ,  F16K17/00 ,  G05D11/00 ,  G05D16/00

CPC分类号： G05D11/003 ,  Y10T137/2521 ,  Y10T137/263

摘要： A pressure equilibrator has a slider received slidably in a pressure accumulation chamber and partitioning the chamber into two opposing sections, and a relief port formed in the inner side surface of the chamber. The slider is inserted into the pressure accumulation chamber with a minute gap left around the slider. Two gases are respectively introduced into the sections of the pressure accumulation chamber to be equilibrated in pressure. The gap provides passageways for connecting the respective sections of the pressure accumulation chamber with the relief port so as to discharge parts of the gases. When the pressures of the two gases are unbalanced, the slider moves in accordance with a difference in the urging forces applied thereto by the gases, causing changes in the flow resistance of the passageways between the respective sections of the pressure accumulation chamber and the relief port, whereby the amounts of the parts of the gases discharged are adjusted so that the urging forces applied to the slider become equal to each other, thereby recovering equilibrium between the pressures of the gases. The pressure equilibrator may be incorporated in a gas mixing apparatus having flow rate resistors, for ensuring the stability of a ratio at which the gases are mixed to form a mixture.

摘要翻译： 压力平衡器具有可滑动地容纳在压力积聚室中并将腔室分隔成两个相对部分的滑块和形成在腔室的内侧表面中的释放口。 滑块被插入到压力积聚室中，在滑块周围留有微小的间隙。 分别将两种气体引入压力积聚室的部分，以在压力下平衡。 间隙提供用于将压力积聚室的各个部分与释放口连接以便排出部分气体的通道。 当两种气体的压力不平衡时，滑块根据由气体施加到其上的推动力的差异而移动，导致压力积聚室的各个部分和排泄口之间的通道的流动阻力的变化 ，由此调节排出的气体的部分量，使得施加到滑块的施加力变得彼此相等，从而恢复气体的压力之间的平衡。 压力平衡器可以结合在具有流量电阻器的气体混合装置中，以确保混合气体以形成混合物的比例的稳定性。

公开(公告)号：US4645647A

公开(公告)日：1987-02-24

申请号：US715261

申请日：1985-03-25

申请人： Kasumi Yoshida ,  Hideo Uchiki ,  Tadafumi Kuroishi

发明人： Kasumi Yoshida ,  Hideo Uchiki ,  Tadafumi Kuroishi

IPC分类号： G01N21/75 ,  G01N35/08

CPC分类号： G01N35/085 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

摘要： A continuous flow analyzer of the type which introduces continuously a carrier liquid into a single tubular conduit to form a stable main carrier stream and injects predetermined volumes of reagent liquid and sample liquid in series into the main carrier stream. The analyzer reduces the consumption of the reagent and can form a stable continuous flow.

公开(公告)号：US5783450A

公开(公告)日：1998-07-21

申请号：US440359

申请日：1995-05-12

申请人： Kasumi Yoshida ,  Junkichi Miura ,  Yoshio Fujii ,  Hiroshi Satake ,  Masahito Ito ,  Masao Kamahori

发明人： Kasumi Yoshida ,  Junkichi Miura ,  Yoshio Fujii ,  Hiroshi Satake ,  Masahito Ito ,  Masao Kamahori

IPC分类号： G01N30/06 ,  G01N21/64 ,  G01N30/08 ,  G01N30/74 ,  G01N30/88 ,  G01N33/88 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G01N30/02

CPC分类号： G01N35/0092 ,  G01N30/88 ,  G01N2030/067 ,  G01N2030/8804 ,  G01N2030/8813 ,  G01N2035/00356 ,  G01N2035/0093 ,  G01N2035/106 ,  G01N21/64 ,  G01N30/06 ,  G01N35/028 ,  G01N35/109 ,  Y10T436/142222 ,  Y10T436/173845 ,  Y10T436/25375

摘要： A method and an instrument for separating and analyzing a very small quantity of constituents to be inspected contained in an analyte such as a class of catecholamines by liquid chromatography after labeling. The entire processes of analytical operations include principally three processes, a preparing process, an impurity elimination process and a separation process. When one sample is perceived, the sample is processed in these three processes. In this case, while one sample is being processed in an impurity elimination process, a sample preceeding the one sample is processed in a separation process, and a succeeding sample is processed in a preparing process. In other words, these three processes are performed essentially in parallel. With this, it is possible to remarkably reduce analysis time as compared with individual single sample analysis.

摘要翻译： 一种方法和仪器，用于通过液相色谱法在标记后通过液相色谱法分离和分析非常少量待检查的成分，包含在分析物如一类儿茶酚胺中。 分析操作的整个过程主要包括三个过程，制备过程，杂质消除过程和分离过程。 当一个样品被感知时，样品在这三个过程中被处理。 在这种情况下，当在杂质消除过程中处理一个样品时，在分离过程中处理先于一个样品的样品，并在制备过程中处理后续样品。 换句话说，这三个过程基本上是并行执行的。 与单个样品分析相比，可以显着减少分析时间。