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    Protein charge regulator and protein-encapsulating polymer micelle complex
    3.
    发明授权
    Protein charge regulator and protein-encapsulating polymer micelle complex 有权
    蛋白质电荷调节剂和蛋白质包封的聚合物胶束复合物

    公开(公告)号：US09051354B2

    公开(公告)日：2015-06-09

    申请号：US13256605

    申请日：2009-09-17

    申请人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

    发明人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

    IPC分类号： A61K47/48 ,  C07K1/113 ,  C07K1/13

    CPC分类号： C07K1/13 ,  A61K47/60 ,  A61K47/645

    摘要： The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.

    摘要翻译： 本发明提供了允许有效地引入细胞（特别是细胞质）中的蛋白质递送装置（例如，聚离子络合物），在血清中是高度稳定的，并且也可广泛应用。 本发明的聚离子络合物包含具有聚阳离子部分和电荷转移蛋白质的阳离子聚合物，其电荷通过特定的电荷调节剂从碱性或中性转变为酸性。

    Method of high-speed detection for biological analyte
    4.
    发明申请
    Method of high-speed detection for biological analyte 失效
    生物分析物高速检测方法

    公开(公告)号：US20070059843A1

    公开(公告)日：2007-03-15

    申请号：US10575551

    申请日：2004-09-06

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/5432

    摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

    摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。

    PROTEIN CHARGE REGULATOR AND PROTEIN-ENCAPSULATING POLYMER MICELLE COMPLEX
    7.
    发明申请
    PROTEIN CHARGE REGULATOR AND PROTEIN-ENCAPSULATING POLYMER MICELLE COMPLEX 有权
    蛋白质电荷调节剂和蛋白质包封聚合物MICELLE复合物

    公开(公告)号：US20120046453A1

    公开(公告)日：2012-02-23

    申请号：US13256605

    申请日：2009-09-17

    申请人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

    发明人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

    IPC分类号： C07K14/00 ,  C07D307/77 ,  C07D307/89 ,  C07D307/32

    CPC分类号： C07K1/13 ,  A61K47/60 ,  A61K47/645

    摘要： The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.

    摘要翻译： 本发明提供了允许有效地引入细胞（特别是细胞质）中的蛋白质递送装置（例如，聚离子络合物），在血清中是高度稳定的，并且也可广泛应用。 本发明的聚离子络合物包含具有聚阳离子部分和电荷转移蛋白质的阳离子聚合物，其电荷通过特定的电荷调节剂从碱性或中性转变为酸性。

    SUGAR-RESPONSIVE GEL AND MEDICINE ADMINISTERING DEVICE
    10.
    发明申请
    SUGAR-RESPONSIVE GEL AND MEDICINE ADMINISTERING DEVICE 审中-公开
    糖果胶和药物管理装置

    公开(公告)号：US20130066264A1

    公开(公告)日：2013-03-14

    申请号：US13699331

    申请日：2011-05-24

    申请人： Akira Matsumoto ,  Takehiko Ishii ,  Kazunori Kataoka ,  Yuji Miyahara

    发明人： Akira Matsumoto ,  Takehiko Ishii ,  Kazunori Kataoka ,  Yuji Miyahara

    IPC分类号： A61K31/69 ,  A61M5/00 ,  C07F5/02

    CPC分类号： A61M5/1723 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0026 ,  A61K47/32 ,  C07F5/025 ,  C07K14/62 ,  Y10S514/866

    摘要： Disclosed are a sugar-responsive gel and a medicine administering device having a pKa more suitable for use in a body environment and capable of administering medicine more autonomously than before. A sugar-responsive gel and an insulin administering device having a pKa more suitable for use in a body environment and capable of administering insulin more autonomously than before, wherein under a body condition of pKa of 7.4 or less and temperature of 35° C.-40° C., when the glucose concentration increases, insulin can be released from a gel body in response thereto, and when the glucose concentration decreases, insulin release from the gel body can be suppressed.

    摘要翻译： 公开了一种糖应答凝胶和具有更适合用于身体环境并且能够比以前更自主地给予药物的pKa的给药装置。 一种糖响应性凝胶和具有更适合用于身体环境并能够比以前更自主地施用胰岛素的pKa的胰岛素给药装置，其中在pKa为7.4以下，体温35℃的身体条件下， 40℃时，当葡萄糖浓度增加时，响应于胰岛素可以从凝胶体释放，并且当葡萄糖浓度降低时，可以抑制从凝胶体释放的胰岛素。