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22 条记录 (耗时 0.026 秒)

    Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein
    1.
    发明申请
    Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein 有权
    三维体外脊髓模型及其分析物质分布的方法

    公开(公告)号：US20050106545A1

    公开(公告)日：2005-05-19

    申请号：US10957359

    申请日：2004-10-01

    申请人： Kenneth Heruth ,  Mark Lent ,  Michael Hegland

    发明人： Kenneth Heruth ,  Mark Lent ,  Michael Hegland

    IPC分类号： G09B23/28 ,  G09B23/30 ,  G09B23/34

    CPC分类号： G09B23/34 ,  B33Y50/00 ,  B33Y80/00 ,  G09B23/30

    摘要： An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticum of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.

    摘要翻译： 人体脊柱体外模型装置及其中物质分布模式的检测和分析方法。 在一个实施例中，模型设备包括定义通道的柱体，该通道基本上模拟成年人脊柱的尺寸，形状和结构。 还包括可以位于和锚定在通道内的绳索结构。 帘线结构基本上模仿成年人脊髓的尺寸，形状和结构。 例如，绳索结构可以包括类似神经根，齿状韧带和人脊柱的隔膜的连接元件。 模型装置的通道可以填充有模拟脑脊液（CSF）的第一流体，并且可以将含有药物（或模拟药物）的第二流体引入通道中，之后药物在通道内的分布 可以分析。

    Porous coatings for drug release from medical devices
    3.
    发明申请
    Porous coatings for drug release from medical devices 审中-公开
    从医疗器械释放药物的多孔涂层

    公开(公告)号：US20050079199A1

    公开(公告)日：2005-04-14

    申请号：US10933734

    申请日：2004-09-03

    申请人： Kenneth Heruth ,  Edouard Koullick ,  Mark Lent

    发明人： Kenneth Heruth ,  Edouard Koullick ,  Mark Lent

    IPC分类号： A61K9/50 ,  A61M5/00 ,  A61M27/00 ,  A61M29/00

    CPC分类号： A61M27/006

    摘要： Extravascular implantable medical devices are described. The devices include a polymeric layer comprising a polymeric matrix and pores. Therapeutic agent is loaded in the matrix, in the pores, or in the matrix and the pores. The devices include a structural surface layer. Additional therapeutic agent may be loaded in or on the surface layer. The devices may also include one or more intermediate layer, into or onto which additional therapeutic agent may be loaded.

    摘要翻译： 描述了血管内可植入医疗装置。 所述装置包括聚合物层，其包含聚合物基质和孔。 治疗剂加载到基质，孔中或基质和孔中。 这些装置包括结构表面层。 另外的治疗剂可以装载在表面层中或表面层上。 装置还可以包括一个或多个中间层，可以加载另外的治疗剂。

    Drug eluting medical device
    4.
    发明申请
    Drug eluting medical device 审中-公开
    药物洗脱医疗器械

    公开(公告)号：US20060039946A1

    公开(公告)日：2006-02-23

    申请号：US10975253

    申请日：2004-10-28

    申请人： Kenneth Heruth ,  Mark Lent

    发明人： Kenneth Heruth ,  Mark Lent

    IPC分类号： A61F13/00

    CPC分类号： A61L31/10 ,  A61K9/0024 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/61 ,  A61M37/00 ,  A61M2025/0057 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0551 ,  A61N1/36071

    摘要： Medical devices configured to be implanted in two or more tissues simultaneously are discussed. A therapeutic agent is disposed on, in, or about at least a portion of an external surface of a medical device configured to be placed in one tissue, but not on, in or about a surface configured to be placed in another tissue. The therapeutic agent may be disposed on or in a polymeric material, which is disposed on or about at least a portion of an external surface of first portion the medical device. Such targeted placement of polymeric material may allow for the therapeutic agent to be eluted in an appropriate tissue and may allow for decreased undesired effects.

    摘要翻译： 讨论了被配置为同时植入在两个或更多个组织中的医疗装置。 治疗剂设置在医疗装置的外表面的至少一部分上，或者围绕被配置成放置在一个组织中但不在其上或周围的配置为放置在另一组织中的表面上。 治疗剂可以设置在聚合物材料上或聚合物材料中，聚合物材料设置在医疗装置的第一部分的外表面的至少一部分上或周围。 聚合材料的这种靶向放置可以使治疗剂在适当的组织中洗脱并且可以减少不期望的效果。

    Regional therapies for treatment of pain
    7.
    发明申请
    Regional therapies for treatment of pain 有权
    治疗疼痛的区域疗法

    公开(公告)号：US20070039625A1

    公开(公告)日：2007-02-22

    申请号：US11374793

    申请日：2006-03-14

    申请人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

    发明人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

    IPC分类号： A61B19/00

    CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

    摘要： Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz) frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.

    摘要翻译： 描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。 该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。 例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。 还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输注泵的系统。

    Method of manufacturing drug-eluting medical device
    8.
    发明申请
    Method of manufacturing drug-eluting medical device 审中-公开
    药物洗脱医疗器械的制造方法

    公开(公告)号：US20060051393A1

    公开(公告)日：2006-03-09

    申请号：US10936263

    申请日：2004-09-08

    申请人： Kenneth Heruth ,  Edouard Koullick ,  Mark Lent

    发明人： Kenneth Heruth ,  Edouard Koullick ,  Mark Lent

    IPC分类号： A61L33/00 ,  A61F2/00

    CPC分类号： A61L27/54 ,  A61L27/56 ,  A61L29/146 ,  A61L29/16 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00

    摘要： Methods for manufacturing medical devices comprising a polymeric material capable of releasing a therapeutic agent upon contact with bodily tissue or fluid are described. The method includes generating polymeric material having a matrix into or onto which a therapeutic agent is disposed and having pores. The method further includes disposing additional therapeutic agent into the pores of the polymeric material.

    摘要翻译： 描述了用于制造医疗装置的方法，其包括能够在与身体组织或液体接触时释放治疗剂的聚合物材料。 该方法包括产生具有基质的聚合材料，其中设置治疗剂并具有孔。 该方法还包括将另外的治疗剂置于聚合物材料的孔中。

    Regional therapies for treatment of pain
    10.
    发明申请
    Regional therapies for treatment of pain 有权
    治疗疼痛的区域疗法

    公开(公告)号：US20070021802A1

    公开(公告)日：2007-01-25

    申请号：US11375492

    申请日：2006-03-14

    申请人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

    发明人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

    IPC分类号： A61N1/34

    CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

    摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.

    摘要翻译： 描述了治疗疼痛的增强疗法。 这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。 所述疗法还包括相对于施用高频或低频刺激而在预定时间施用疼痛治疗剂。 描述了通过植入式输注系统递送疼痛治疗剂。 还讨论了输液装置和脉冲发生器的输出协调以提供协调治疗。