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    Device, measuring instrument and process for taking-up and studying or manipulating a sample liquid in a microfluidic platform
    1.
    发明申请
    Device, measuring instrument and process for taking-up and studying or manipulating a sample liquid in a microfluidic platform 有权
    用于在微流体平台中吸收和研究或操纵样品液体的装置，测量仪器和方法

    公开(公告)号：US20060078469A1

    公开(公告)日：2006-04-13

    申请号：US11247584

    申请日：2005-10-12

    申请人： Christian Dechant ,  Klaus Kadel ,  Gert Blankenstein

    发明人： Christian Dechant ,  Klaus Kadel ,  Gert Blankenstein

    IPC分类号： B01L3/00

    CPC分类号： G01N33/48764

    摘要： A device and a plurality of microfluidic platforms for taking up and especially studying or manipulating a sample liquid, a measuring instrument for use with the device and platforms, and a process for performing the studying or manipulating of the sample liquid. Very simple, hygienic and user-friendly handling is enabled in that the platforms which are connected to one another in a sealed state and can each be individually separated and individually, preferably simultaneously, opened for taking up of a sample, such as blood, for, e.g., performing a glucose determination.

    摘要翻译： 用于吸收和特别研究或操纵样品液体的装置和多个微流体平台，与装置和平台一起使用的测量仪器以及用于执行对样品液体的研究或操纵的过程。 能够进行非常简单，卫生和用户友好的处理，因为在密封状态下彼此连接的平台可以单独分离并且单独地，优选地同时打开以吸收诸如血液的样品， ，例如进行葡萄糖测定。

    Device for taking-up and studying or manipulating a sample liquid in a microfluidic platform
    4.
    发明授权
    Device for taking-up and studying or manipulating a sample liquid in a microfluidic platform 有权
    用于在微流体平台中摄取和研究或操纵样品液体的装置

    公开(公告)号：US07815857B2

    公开(公告)日：2010-10-19

    申请号：US11247584

    申请日：2005-10-12

    申请人： Christian Dechant ,  Klaus Kadel ,  Gert Blankenstein

    发明人： Christian Dechant ,  Klaus Kadel ,  Gert Blankenstein

    IPC分类号： B01L3/00

    CPC分类号： G01N33/48764

    摘要： A device and a plurality of microfluidic platforms for taking up and especially studying or manipulating a sample liquid, a measuring instrument for use with the device and platforms, and a process for performing the studying or manipulating of the sample liquid. Very simple, hygienic and user-friendly handling is enabled in that the platforms which are connected to one another in a sealed state and can each be individually separated and individually, preferably simultaneously, opened for taking up of a sample, such as blood, for, e.g., performing a glucose determination.

    摘要翻译： 用于吸收和特别研究或操纵样品液体的装置和多个微流体平台，与装置和平台一起使用的测量仪器以及用于执行对样品液体的研究或操纵的过程。 能够进行非常简单，卫生和用户友好的处理，因为在密封状态下彼此连接的平台可以单独分离并且单独地，优选地同时打开以吸收诸如血液的样品， ，例如进行葡萄糖测定。

    METHODS AND SYSTEMS FOR POINT-OF-CARE COAGULATION ASSAYS BY OPTICAL DETECTION
    6.
    发明申请
    METHODS AND SYSTEMS FOR POINT-OF-CARE COAGULATION ASSAYS BY OPTICAL DETECTION 审中-公开
    通过光学检测进行点状凝集测定的方法和系统

    公开(公告)号：US20150316533A1

    公开(公告)日：2015-11-05

    申请号：US14696756

    申请日：2015-04-27

    申请人： Josef Kerimo ,  Hansong Zeng ,  Ron Scharlack ,  Gert Blankenstein

    发明人： Josef Kerimo ,  Hansong Zeng ,  Ron Scharlack ,  Gert Blankenstein

    IPC分类号： G01N33/49 ,  G01N21/65 ,  G01N21/64

    CPC分类号： G01N21/534 ,  G01N21/59 ,  G01N21/6408 ,  G01N21/6486 ,  G01N21/65 ,  G01N33/4905 ,  G01N2201/062 ,  G01N2201/0636

    摘要： This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.

    摘要翻译： 本发明涉及一种用于进行浊度测定的光学系统和方法，例如， 血液或血浆的凝结，包括标准光学参考，样品处理结构，光源和光学检测单元。 诸如荧光团掺杂玻璃的标准光学参考在受控的光学条件下提供恒定的光学信号。 样品处理结构，如具有反应室的微流体系统，可放置在标准光学参考下方或上方。 在操作过程中，凝固血浆/血液会改变其光吸收和反射特性，导致到达光学读取单元的光信号的变化。 光信号的变化，例如荧光信号表示浊度变化过程的动力学，例如血浆/血液凝固过程。 本发明用于光学系统进行浊度测定，包括光度测定系统，荧光系统，拉曼光谱系统等。

    BIOASSAY SYSTEM AND METHOD FOR DETECTING ANALYTES IN BODY FLUIDS
    7.
    发明申请
    BIOASSAY SYSTEM AND METHOD FOR DETECTING ANALYTES IN BODY FLUIDS 审中-公开
    生物体系和检测体液中分析物的方法

    公开(公告)号：US20150268237A1

    公开(公告)日：2015-09-24

    申请号：US14663560

    申请日：2015-03-20

    申请人： Josef Kerimo ,  Hansong Zeng ,  Ron Scharlack ,  Gert Blankenstein

    发明人： Josef Kerimo ,  Hansong Zeng ,  Ron Scharlack ,  Gert Blankenstein

    IPC分类号： G01N33/543 ,  G01N21/41

    CPC分类号： G01N33/54373 ,  G01N21/658 ,  G01N21/7743 ,  G01N33/54346 ,  G01N33/588

    摘要： A bioserisor platform is configured with upconverting nanoparticles on the surface of a resonant grating structure with enhanced sensitivity. The grating structure is illuminated with a light beam at one of its resonance modes to form a strong evanescent field at the surface and used for high sensitivity assays. The strong evanescent field triggers the upconverting nanoparticles to generate enhanced and localized emission on the grating surface, with lower background and lower auto-fluorescence from the grating substrate. This leads to improved performance in detecting analytes in bioassays.

    摘要翻译： 生物传感器平台配置为在谐振光栅结构的表面上上变换纳米颗粒，具有增强的灵敏度。 光栅结构以其共振模式之一的光束照射，以在表面形成强烈的消逝场，并用于高灵敏度测定。 强衰减场触发上变换纳米粒子，以在光栅表面产生增强和局部发射，具有较低的背景和较低的光栅衬底的自发荧光。 这导致在生物测定中检测分析物方面的改进性能。

    Microfluidic Platform
    8.
    发明申请
    Microfluidic Platform 审中-公开
    微流控平台

    公开(公告)号：US20140166108A1

    公开(公告)日：2014-06-19

    申请号：US13877720

    申请日：2011-10-04

    申请人： Tobias Rodenfels ,  Thanh Tu Hellmich-Duong ,  Gert Blankenstein

    发明人： Tobias Rodenfels ,  Thanh Tu Hellmich-Duong ,  Gert Blankenstein

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50273 ,  B01L2300/045 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2400/0481 ,  B01L2400/0655 ,  Y10T137/0318

    摘要： The invention relates to a microfluidic platform (1) having at least one means (12) for initiating a movement of a liquid (P), in particular a sample liquid, between at least two locations (100, 101) of the microfluidic platform (1).It is proposed according to the invention that the means (12) is embodied as an element of changeable volume and/or shape and is mounted on a cover-like component (11) that is movably connected to the microfluidic platform (1). By moving of the component (11) the element (12) can be brought into a position such that, by changing its volume and/or shape, it causes the liquid (P) situated at the location (100) to be moved at least partly from this location (100) to the other location (101).In this way a sample liquid (P) can be transferred from a sample application point (100) to a sample utilisation area (101) in a very simple and reliable manner.The invention further proposes a method by which a movement of a liquid between two locations can be initiated, while this can be done in particular using a microfluidic platform (1) according to the invention.

    摘要翻译： 本发明涉及一种微流体平台（1），其具有至少一个装置（12），用于在微流体平台的至少两个位置（100,101）之间启动液体（P），特别是样品液体的运动 1）。 根据本发明提出，装置（12）被实施为可变容积和/或形状的元件，并且安装在可移动地连接到微流体平台（1）的盖状部件（11）上。 通过移动部件（11），元件（12）可以进入这样的位置，使得通过改变其体积和/或形状，使得位于位置（100）处的液体（P）至少移动 部分地从该位置（100）到另一位置（101）。 以这种方式，样品液体（P）可以以非常简单和可靠的方式从样品施加点（100）转移到样品利用区域（101）。 本发明还提出了一种可以启动两个位置之间的液体的运动的方法，而这可以特别地使用根据本发明的微流体平台（1）进行。

    MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS
    9.
    发明申请
    MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS 有权
    用于测量流体的微流体结构

    公开(公告)号：US20110135546A1

    公开(公告)日：2011-06-09

    申请号：US12995550

    申请日：2009-06-02

    申请人： Dirk Kurowski ,  Mario Hempel ,  Gert Blankenstein ,  Tobias Rodenfels

    发明人： Dirk Kurowski ,  Mario Hempel ,  Gert Blankenstein ,  Tobias Rodenfels

    IPC分类号： B01L3/00 ,  B32B37/00

    CPC分类号： F16K99/0001 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0689 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0638 ,  B01L2400/0688 ,  B01L2400/082 ,  B29C65/18 ,  B29C66/1122 ,  B29C66/328 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/723 ,  B29C66/81419 ,  B29C66/81422 ,  B29C66/8181 ,  B29C66/8322 ,  B29L2031/756 ,  F04B43/043 ,  B29K2021/003 ,  B29K2023/00 ,  B29K2023/06 ,  B29K2023/08 ,  B29K2023/083 ,  B29K2023/12 ,  B29K2023/14 ,  B29K2023/16 ,  B29K2027/18 ,  B29K2033/08 ,  B29K2077/00

    摘要： The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.

    摘要翻译： 本发明涉及用于将液体计量到微流控网络中的微流体装置。 微流体通道或室至少部分地通过将合适的结构引入到衬底载体上方的膜中而形成，使得通过网络的流体中的至少一些流动发生在衬底的平面之上。 为了在膜中形成稳定的通道结构或腔室结构，设想在未连接和附接部分之间的边缘区域中，当膜粘合到膜材料上时，由材料的粘性流形成楔形材料 衬底，该楔形件形成在室壁和衬底之间的过渡部分，并且使腔壁在衬底的平面上方升高。 在制造成品微流体结构的一种方法中，将平坦的平面薄膜层压在平板状基片上。 在层压期间，具有至少一个凹部或开口的掩模在压力和/或受热的作用下被压在膜上和衬底上。 因此，膜被带到膜和/或基底介质粘性流入凹部或开口的区域的温度，使得形成楔形材料，并且膜在凹部的区域中凸起 形成一个房间。 本发明还涉及在微流体网络中计量至少一种液体的方法，其中通过致动膜来克服毛细管塞，当毛细管停止被去除时，膜被润湿。

    APPARATUS FOR THE SEPARATION OF PLASMA
    10.
    发明申请
    APPARATUS FOR THE SEPARATION OF PLASMA 有权
    用于分离等离子体的装置

    公开(公告)号：US20110011781A1

    公开(公告)日：2011-01-20

    申请号：US12867335

    申请日：2009-02-26

    申请人： Gert Blankenstein ,  Holger Bartos ,  Ralf-Peter Peters ,  Christian Schoen

    发明人： Gert Blankenstein ,  Holger Bartos ,  Ralf-Peter Peters ,  Christian Schoen

    IPC分类号： B01D63/00 ,  B01D35/00 ,  B01D35/02

    CPC分类号： B01L3/502753 ,  B01D29/014 ,  B01D29/05 ,  B01D61/18 ,  B01D63/08 ,  B01D63/087 ,  B01D63/088 ,  B01D2201/0415 ,  B01D2201/44 ,  B01L3/502715 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2400/0406 ,  G01N33/491

    摘要： The invention relates to an apparatus for separating blood, more particularly an apparatus (1) for absorbing blood (19) and separating blood components, e.g. blood plasma, as a sample liquid (2). Said apparatus (1) comprises a feeding device (13) for absorbing the blood (2), a device (15) for separating blood components as a sample liquid (2), a duct which preferably absorbs the sample liquid (2) exclusively by means of capillary forces, and a device for filling the duct (3) with sample liquid (2) in an inlet or feeding zone (18) of the duct (3). The separating device (15), in particular a membrane, is curved, especially convexly shaped, and the apex of said curved, especially convex shape projects into the filling device.

    摘要翻译： 本发明涉及一种用于分离血液的装置，更具体地说，涉及用于吸收血液（19）并分离血液成分的装置（1）。 血浆，作为样品液体（2）。 所述装置（1）包括用于吸收血液（2）的供给装置（13），用于分离作为样品液体（2）的血液成分的装置（15），优选地通过以下方式吸收样品液体 以及用于在管道（3）的入口或进料区（18）中用样品液体（2）填充管道（3）的装置。 分离装置（15），特别是膜是弯曲的，特别是凸形的，并且所述弯曲的，特别是凸形的顶点突出到填充装置中。