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    Apparatus for gene therapy
    3.
    发明授权
    Apparatus for gene therapy 失效
    基因治疗仪

    公开(公告)号：US5702384A

    公开(公告)日：1997-12-30

    申请号：US458910

    申请日：1995-06-02

    申请人： Koichi Umeyama ,  Tadahiko Ogasawara ,  Kenji Yoshino ,  Katsushi Watanabe ,  Koji Koda

    发明人： Koichi Umeyama ,  Tadahiko Ogasawara ,  Kenji Yoshino ,  Katsushi Watanabe ,  Koji Koda

    IPC分类号： A61M37/00 ,  A61B17/00 ,  A61K48/00 ,  A61N1/32 ,  B81B7/00 ,  C12M1/00 ,  C12N15/09 ,  C12N15/88 ,  C12N15/89 ,  A61K9/22 ,  C12N15/00

    CPC分类号： A61N1/325 ,  C12N15/89 ,  A61B18/22 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M37/00 ,  A61N1/306

    摘要： There is provided an apparatus for gene therapy to transfer or introduce, in vivo, a gene for treatment into a cell located at a target portion of a patient, so that the gene can be transferred with a high probability within a short period of time. The apparatus is applicable to all cell species. In addition to simple supply of a gene to the cell of the patient, the gene is forcibly transferred to the cell without depending on natural cellular physiology. For example, catheters are mounted on a probe inserted into a body cavity, and the gene is supplied from a reservoir which stores the gene to the surface of a human living cell of the target portion in the body cavity through needle cannulas attached to the distal ends of the catheters. A pulse voltage is applied to the needle cannulas to form a pore in the surface of the human living cell upon application of the pulse voltage. The gene is transferred into the human living cell through the pore.

    摘要翻译： 提供了一种用于基因治疗的装置，用于在体内将用于治疗的基因转移或引入位于患者的目标部分的细胞，使得可以在短时间内以高概率转移基因。 该装置适用于所有细胞种类。 除了简单地向患者细胞提供基因之外，该基因被强制转移到细胞中，而不依赖于天然的细胞生理学。 例如，将导管安装在插入体腔内的探针上，并且通过连接到远端的针插管将基因从存储基因的储器供给到体腔内的目标部分的人活细胞的表面 导管的末端。 脉冲电压施加到针插管，以在施加脉冲电压时在人活细胞表面形成孔。 该基因通过孔转移到人活细胞中。

    Aqueous resin composition
    5.
    发明授权
    Aqueous resin composition 失效
    水性树脂组合物

    公开(公告)号：US4436849A

    公开(公告)日：1984-03-13

    申请号：US431080

    申请日：1982-09-30

    申请人： Tetsuo Aihara ,  Yasuharu Nakayama ,  Koichi Umeyama ,  Kozo Sawada ,  Masaaki Shinohara

    发明人： Tetsuo Aihara ,  Yasuharu Nakayama ,  Koichi Umeyama ,  Kozo Sawada ,  Masaaki Shinohara

    IPC分类号： C08F2/26 ,  C08G63/685 ,  C09D167/08 ,  C08L67/08 ,  C09D3/68

    CPC分类号： C08G63/6854 ,  C09D167/08

    摘要： An aqueous resin composition comprising a neutralization product of an isocyanurate group-containing maleinized alkyd resin having an acid value of 5 to 65 in an aqueous medium, said maleinized alkyd resin being prepared by maleinizing an alkyd resin having an acid value of not more than 10 and a hydroxyl value of not more than 10 which is the product of condensation reaction of(A) 20 to 60% by weight of at least one of drying or semi-drying oils and fatty acids,(B) 10 to 45% by weight of at least one tris(hydroxyalkyl) isocyanurate,(C) 0 to 45% by weight of at least one polyhydric alcohol other than the component (B),(D) 10 to 45% by weight of at least one polybasic acid, and(E) 0 to 15% by weight of at least one monobasic acidand an aqueous emulsion resin composition obtained by emulsion polymerization of a radical polymerizable unsaturated monomer in an aqueous medium in the presence of the aforesaid neutralization product. The above aqueous resin compositions can give a coating having excellent corrosion resistance and fast-drying property.

    摘要翻译： 一种含水树脂组合物，其包含在水性介质中含有酸值为5〜65的含异氰脲酸酯基的马来酸化醇酸树脂的中和产物，所述马来酸化的醇酸树脂通过使酸值不大于10的醇酸树脂 和（A）20至60重量％的干燥或半干性油和脂肪酸中的至少一种的缩合反应的产物的羟值为10以下，（B）10〜45重量％ 的至少一种三（羟烷基）异氰脲酸酯，（C）0至45重量％的除（B）成分以外的至少一种多元醇，（D）10至45重量％的至少一种多元酸，以及 （E）0〜15重量％的至少一种一元酸和通过自由基聚合性不饱和单体在水性介质中在上述中和产物的存在下乳液聚合得到的水性乳液树脂组合物。 上述水性树脂组合物可以得到具有优异的耐腐蚀性和快干性能的涂层。