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    Methods and Systems for Detecting Nucleic Acids
    1.
    发明申请
    Methods and Systems for Detecting Nucleic Acids 审中-公开
    检测核酸的方法和系统

    公开(公告)号：US20110014617A1

    公开(公告)日：2011-01-20

    申请号：US12816006

    申请日：2010-06-15

    申请人： Kristian Scaboo ,  Vissarion Aivazachvili ,  Timothy Liu ,  Robert Eason ,  Konrad Faulstich

    发明人： Kristian Scaboo ,  Vissarion Aivazachvili ,  Timothy Liu ,  Robert Eason ,  Konrad Faulstich

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6834 ,  C12Q1/6823 ,  C12Q1/6825 ,  C12Q2531/113 ,  C12Q2521/307 ,  C12Q2525/204 ,  C12Q2565/607 ,  C12Q2561/109 ,  C12Q2565/519

    摘要： Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising nuclease activity that can cleave the hybridized hybridization probe to thereby release a labeled probe fragment. In some embodiments, the sample can then be contacted with a solid support comprising surface bound capture probes which can hybridize to the labeled probe fragment(s). These capture probes more readily bind to the probe fragment(s) than to the intact hybridization probe. The label can then be detected on the support surface. In this manner, improved discrimination between the probe fragments and the intact hybridization probes can be achieved.

    摘要翻译： 描述了用于检测样品中靶核酸的方法和试剂盒。 在一些实施方案中，待分析的样品包括与靶核酸的至少一部分杂交的引物，具有与靶核酸的至少一部分杂交的第一区的探针和具有可检测的第二区 标记，扩增杂交引物的聚合酶和包含核酸酶活性的酶，其可以切割杂交的杂交探针，从而释放标记的探针片段。 在一些实施方案中，然后可以将样品与包含可以与标记的探针片段杂交的表面结合捕获探针的固体支持物接触。 这些捕获探针比完整的杂交探针更容易与探针片段结合。 然后可以在支撑表面上检测标签。 以这种方式，可以实现探针片段与完整杂交探针之间的改善的区别。

    METHODS AND SYSTEMS FOR DETECTING NUCLEIC ACIDS
    2.
    发明申请
    METHODS AND SYSTEMS FOR DETECTING NUCLEIC ACIDS 审中-公开
    检测核酸的方法和系统

    公开(公告)号：US20080241838A1

    公开(公告)日：2008-10-02

    申请号：US11965837

    申请日：2007-12-28

    申请人： Kristian Scaboo ,  Vissarion Aivazachvili ,  Timothy Liu ,  Robert Eason ,  Konrad Faulstich

    发明人： Kristian Scaboo ,  Vissarion Aivazachvili ,  Timothy Liu ,  Robert Eason ,  Konrad Faulstich

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6834 ,  C12Q1/6823 ,  C12Q1/6825 ,  C12Q2531/113 ,  C12Q2521/307 ,  C12Q2525/204 ,  C12Q2565/607 ,  C12Q2561/109 ,  C12Q2565/519

    摘要： Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising nuclease activity that can cleave the hybridized hybridization probe to thereby release a labeled probe fragment. In some embodiments, the sample can then be contacted with a solid support comprising surface bound capture probes which can hybridize to the labeled probe fragment(s). These capture probes more readily bind to the probe fragment(s) than to the intact hybridization probe. The label can then be detected on the support surface. In this manner, improved discrimination between the probe fragments and the intact hybridization probes can be achieved.

    摘要翻译： 描述了用于检测样品中靶核酸的方法和试剂盒。 在一些实施方案中，待分析的样品包括与靶核酸的至少一部分杂交的引物，具有与靶核酸的至少一部分杂交的第一区的探针和具有可检测的第二区 标记，扩增杂交引物的聚合酶和包含核酸酶活性的酶，其可以切割杂交的杂交探针，从而释放标记的探针片段。 在一些实施方案中，然后可以将样品与包含可以与标记的探针片段杂交的表面结合捕获探针的固体支持物接触。 这些捕获探针比完整的杂交探针更容易与探针片段结合。 然后可以在支撑表面上检测标签。 以这种方式，可以实现探针片段与完整杂交探针之间的改善的区别。

    DECONVOLUTION OF DIGITAL IMAGES
    4.
    发明申请
    DECONVOLUTION OF DIGITAL IMAGES 有权
    数字图像的解构

    公开(公告)号：US20120087551A1

    公开(公告)日：2012-04-12

    申请号：US12903072

    申请日：2010-10-12

    申请人： Varun Bhagwan ,  Timothy Liu ,  Justin Ormont ,  Heather Underwood

    发明人： Varun Bhagwan ,  Timothy Liu ,  Justin Ormont ,  Heather Underwood

    IPC分类号： G06K9/00 ,  G06K9/40 ,  G06K9/68

    CPC分类号： G06K7/146 ,  G06K9/00255 ,  G06K9/36 ,  G06K9/46 ,  G06K2009/363 ,  G06K2209/01 ,  G06T3/0056 ,  G06T3/0068 ,  G06T5/003 ,  G06T2207/10004 ,  G06T2207/10024

    摘要： A method for deconvolution of digital images includes obtaining a degraded image from a digital sensor, a processor accepting output from the digital sensor and recognizing a distorted element within the image. The distorted element is compared with a true shape of the element to produce a degrading function. The degrading function is deconvolved from at least a portion of the image to improve image quality of the image. A method of indirectly decoding a barcode includes obtaining an image of a barcode using an optical sensor in a mobile computing device, the image comprising barcode marks and a textual character. The textual character is optically recognized and an image degrading characteristic is identified from the textual character. Compensating for the image degrading characteristic renders previously undecodable barcode marks decodable. A system for deconvolution of digital images is also included.

    摘要翻译： 数字图像的去卷积的方法包括从数字传感器获得退化图像，处理器接受来自数字传感器的输出并识别图像内的失真元件。 将失真元件与元件的真实形状进行比较以产生降级功能。 降解功能从图像的至少一部分去卷积，以提高图像的图像质量。 间接解码条形码的方法包括：在移动计算装置中使用光学传感器获得条形码的图像，该图像包括条形码标记和文本字符。 文本字符被光学识别，并且从文本字符识别图像降级特征。 补偿图像降级特征使得先前不可解码的条形码标记可解码。 还包括数字图像的去卷积系统。

    Dual electrode injection of analyte into a capillary electrophoretic device
    5.
    发明申请
    Dual electrode injection of analyte into a capillary electrophoretic device 审中-公开
    分析物双电极注入毛细管电泳装置

    公开(公告)号：US20070045115A1

    公开(公告)日：2007-03-01

    申请号：US11590461

    申请日：2006-10-31

    申请人： Charles Vann ,  Timothy Liu

    发明人： Charles Vann ,  Timothy Liu

    IPC分类号： C07K1/26

    CPC分类号： G01N27/44743 ,  G01N2001/4038

    摘要： An injection system including a first electrical circuit for concentration of an analyte and a second electrical circuit for injection of the concentrated analyte into an electrophoretic device is described, as well as methods of using the injection system.

    摘要翻译： 描述了包括用于浓缩分析物的第一电路和用于将浓缩分析物注入电泳装置的第二电路的注射系统，以及使用注射系统的方法。

    Network defense system utilizing endpoint health indicators and user identity
    7.
    发明授权
    Network defense system utilizing endpoint health indicators and user identity 有权
    网络防御系统利用端点健康指标和用户身份

    公开(公告)号：US08001610B1

    公开(公告)日：2011-08-16

    申请号：US11236987

    申请日：2005-09-28

    申请人： Roger Chickering ,  Sampath Srinivas ,  Timothy Liu

    发明人： Roger Chickering ,  Sampath Srinivas ,  Timothy Liu

    IPC分类号： G06F7/04

    CPC分类号： H04L67/125 ,  G06F21/00 ,  H04L29/06 ,  H04L63/105 ,  H04L63/20

    摘要： An endpoint defense system uses endpoint health indicators and user identity information to provide fine-grain access control over network resources. For example, the endpoint defense system may include a controller, a set of protection devices, and a set of agents. The agents are software applications installed on a set of endpoints to gather the health information that represents security states of the endpoint devices. The agents send updated health information to the controller. In response to a login attempt, the controller processes the health indicators and identity information through a set of administrator-defined policies to generate a set of access rights. The controller transfers the set of access rights to the protection devices. The protection devices then control user access to network resources according to the set of access rights. The controller sends updated sets of access rights to the protection devices whenever the access rights change.

    摘要翻译： 端点防御系统使用端点健康指标和用户身份信息来提供对网络资源的细粒度访问控制。 例如，端点防御系统可以包括控制器，一组保护装置和一组代理。 这些代理是安装在一组端点上的软件应用程序，用于收集表示端点设备安全状态的运行状况信息。 代理将更新的健康信息发送给控制器。 响应于登录尝试，控制器通过一组管理员定义的策略处理健康指示符和身份信息，以生成一组访问权限。 控制器将一组访问权限传递给保护设备。 然后，保护设备根据一组访问权限控制用户对网络资源的访问。 只要访问权限发生变化，控制器就会向保护设备发送更新的访问权限集。

    Deconvolution of digital images
    10.
    发明授权
    Deconvolution of digital images 有权
    数字图像的去卷积

    公开(公告)号：US08792748B2

    公开(公告)日：2014-07-29

    申请号：US12903072

    申请日：2010-10-12

    申请人： Varun Bhagwan ,  Timothy Liu ,  Justin Ormont ,  Heather Underwood

    发明人： Varun Bhagwan ,  Timothy Liu ,  Justin Ormont ,  Heather Underwood

    IPC分类号： G06K9/40

    CPC分类号： G06K7/146 ,  G06K9/00255 ,  G06K9/36 ,  G06K9/46 ,  G06K2009/363 ,  G06K2209/01 ,  G06T3/0056 ,  G06T3/0068 ,  G06T5/003 ,  G06T2207/10004 ,  G06T2207/10024

    摘要： A method for deconvolution of digital images includes obtaining a degraded image from a digital sensor, a processor accepting output from the digital sensor and recognizing a distorted element within the image. The distorted element is compared with a true shape of the element to produce a degrading function. The degrading function is deconvolved from at least a portion of the image to improve image quality of the image. A method of indirectly decoding a barcode includes obtaining an image of a barcode using an optical sensor in a mobile computing device, the image comprising barcode marks and a textual character. The textual character is optically recognized and an image degrading characteristic is identified from the textual character. Compensating for the image degrading characteristic renders previously undecodable barcode marks decodable. A system for deconvolution of digital images is also included.

    摘要翻译： 数字图像的去卷积的方法包括从数字传感器获得退化图像，处理器接受来自数字传感器的输出并识别图像内的失真元件。 将失真元件与元件的真实形状进行比较以产生降级功能。 降解功能从图像的至少一部分去卷积，以提高图像的图像质量。 间接解码条形码的方法包括：在移动计算装置中使用光学传感器获得条形码的图像，该图像包括条形码标记和文本字符。 文本字符被光学识别，并且从文本字符识别图像降级特征。 补偿图像降级特征使得先前不可解码的条形码标记可解码。 还包括数字图像的去卷积系统。