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公开(公告)号：US08389960B2
公开(公告)日：2013-03-05
申请号：US13295028
申请日：2011-11-11
Applicant: Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
Inventor： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC: G01N21/64
CPC classification number: G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造产率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。
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公开(公告)号：US20090305908A1
公开(公告)日：2009-12-10
申请号：US12482767
申请日：2009-06-11
Applicant: Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
Inventor： Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
CPC classification number: C12Q1/6874 , C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N21/6486 , G01N2021/6441 , C12Q2563/107
Abstract: A method for preferentially localizing desired molecules within an optical confinement disposed upon a substrate is disclosed. The desired molecules are deposited over the surface of the substrate. The desired molecules that are not within the optical confinement are selectively removed from the surface of the substrate.
Abstract translation: 公开了一种用于在设置在基板上的光限制内优先定位所需分子的方法。 期望的分子沉积在衬底的表面上。 不在光学限制范围内的期望分子被选择性地从衬底的表面去除。
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3.发明申请Thermal Cycler for Automatic Performance of the Polymerase Chain Reaction with Close Temperature Control 失效热循环仪用于自动性能的聚合酶链反应与温度控制公开(公告)号：US20080138887A2
公开(公告)日：2008-06-12
申请号：US11433872
申请日：2006-05-12
Applicant: John Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
Inventor： John Atwood , Albert Mossa , Lisa Goven , Fenton Williams , Timothy Woudenberg , Marcel Margulies , Robert Ragusa , Richard Leath , Clive Miles
IPC: C12M1/38
CPC classification number: B01L3/50851 , B01L3/50853 , B01L7/00 , B01L7/52 , B01L2200/147 , B01L2300/042 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G05D23/1917 , Y10S435/809
Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.
Abstract translation: 提供了用于自动执行聚合酶链式反应的热循环仪。 热循环仪包括提供对反应的温度控制的加热器控制。
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公开(公告)号：US20070154921A1
公开(公告)日：2007-07-05
申请号：US11611339
申请日：2006-12-15
Applicant: Timothy Woudenberg , Meng Taing
Inventor： Timothy Woudenberg , Meng Taing
CPC classification number: G01N21/6445 , C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6432 , C12Q2527/113 , C12Q2525/186 , C12Q2523/319
Abstract: System and methods according to exemplary embodiments of the present disclosure utilize a sample holder configured to hold at least one confined single-molecule analyte in a solution of labeled nucleotide bases. Each single-molecule analyte has a single template nucleic acid molecule, an oligonucleotide primer, and/or a single nucleic acid polymerizing enzyme. A least one light source is used to illuminate a detection volume around each confined analyte, and a pulsed source sends a pulsed radiation to the at least one detection volume. The timing of incorporation events at the analytes are controlled by the pulsed radiation, and when multiple analytes are provided on the sample holder, the incorporation events at the analytes can be phase locked and synchronized using the pulsed radiation.
Abstract translation: 根据本公开的示例性实施方案的系统和方法使用样品保持器，其被配置为将至少一个限制的单分子分析物保持在标记的核苷酸碱基的溶液中。 每个单分子分析物具有单个模板核酸分子，寡核苷酸引物和/或单个核酸聚合酶。 至少一个光源用于照亮围绕每个受限分析物的检测体积，并且脉冲源将脉冲辐射发送到至少一个检测体积。 分析物上的掺入事件的时间由脉冲辐射控制，当样品架上提供多个分析物时，分析物上的结合事件可以使用脉冲辐射进行锁相和同步。
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公开(公告)号：US20060127939A1
公开(公告)日：2006-06-15
申请号：US11341732
申请日：2006-01-27
Applicant: Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Raqusa , Emily Winn-Deen
Inventor： Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Raqusa , Emily Winn-Deen
CPC classification number: C12Q1/6816 , B01J2219/00317 , B01J2219/00599 , B01J2219/00722 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/049 , C12Q1/08 , C40B40/06 , C40B50/08 , C40B60/14 , G01N21/6452 , G01N2035/00148 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , C12Q2565/631
Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
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Patent Agency Ranking
公开(公告)号：US20050074774A1
公开(公告)日：2005-04-07
申请号：US10652430
申请日：2003-08-29
Applicant: Timothy Woudenberg , Dar Bahatt , Muhammad Sharaf , Timothy Liu , Serguei Ermakov , Charles Connell , Jens Hyldig-Nielsen
Inventor： Timothy Woudenberg , Dar Bahatt , Muhammad Sharaf , Timothy Liu , Serguei Ermakov , Charles Connell , Jens Hyldig-Nielsen
CPC classification number: C12Q1/6827 , C12Q1/6858 , C12Q2565/1025 , C12Q2563/185 , C12Q2535/131 , C12Q2563/107
Abstract: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in a sample, the methods employing employ single molecule detection techniques to individually detect at least one molecular complex or at least part of a molecular complex.
Abstract translation: 本发明一般涉及检测分析物，特别是样品中的生物分子。 本发明还涉及通常以多重检测形式检测分析物的存在的组合物，方法和试剂盒。 本发明还涉及用于确定样品中至少一种分析物的存在的方法，采用单分子检测技术单独检测至少一种分子复合物或至少部分分子复合物的方法。
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公开(公告)号：US08058630B2
公开(公告)日：2011-11-15
申请号：US12688462
申请日：2010-01-15
Applicant: Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
Inventor： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC: G01N21/64
CPC classification number: G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造产率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。
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公开(公告)号：US07888108B2
公开(公告)日：2011-02-15
申请号：US11811501
申请日：2007-06-11
Applicant: Timothy Woudenberg , Michael Albin , Reid B. Kowallis , Yefim Raysberg , Robert P. Ragusa , Emily S. Winn-Deen
Inventor： Timothy Woudenberg , Michael Albin , Reid B. Kowallis , Yefim Raysberg , Robert P. Ragusa , Emily S. Winn-Deen
CPC classification number: C12Q1/6816 , B01J2219/00317 , B01J2219/00599 , B01J2219/00722 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/049 , C12Q1/08 , C40B40/06 , C40B50/08 , C40B60/14 , G01N21/6452 , G01N2035/00148 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , C12Q2565/631
Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, presence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
Abstract translation: 本发明涉及用于同时测试样品中多种所选分析物中一种或多种的存在，存在和/或量的方法和装置。 本发明在一个方面包括用于检测或定量液体样品中的多种不同分析物的装置。 每个室可以包括有效地与可能存在于样品中的选定分析物反应的分析物特异性试剂和用于检测信号的检测装置。 还公开了利用该装置的方法。
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公开(公告)号：US20070111299A1
公开(公告)日：2007-05-17
申请号：US11651318
申请日：2007-01-09
Applicant: Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Ragusa , Emily Winn-Deen
Inventor： Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Ragusa , Emily Winn-Deen
IPC: C12M1/34
CPC classification number: C12Q1/6816 , B01J2219/00317 , B01J2219/00599 , B01J2219/00722 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/049 , C12Q1/08 , C40B40/06 , C40B50/08 , C40B60/14 , G01N21/6452 , G01N2035/00148 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , C12Q2565/631
Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
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10.发明申请Compositions and methods for clonal amplification and analysis of polynucleotides 审中-公开用于克隆扩增和分析多核苷酸的组合物和方法公开(公告)号：US20060269934A1
公开(公告)日：2006-11-30
申请号：US11377763
申请日：2006-03-16
Applicant: Timothy Woudenberg , Cheryl Heiner , Eric Nordman
Inventor： Timothy Woudenberg , Cheryl Heiner , Eric Nordman
CPC classification number: C12Q1/6846 , C12Q1/6844 , C12Q2565/501 , C12Q2537/143 , C12Q2527/125
Abstract: Compositions and methods of use are disclosed for clonally amplifying and analyzing one or more polynucleotides.
Abstract translation: 公开了用于克隆扩增和分析一种或多种多核苷酸的组合物和使用方法。
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