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47 条记录 (耗时 0.05 秒)

    Reversibly cross-linked hydrogels
    1.
    发明授权
    Reversibly cross-linked hydrogels 失效
    可逆交联水凝胶

    公开(公告)号：US06790840B1

    公开(公告)日：2004-09-14

    申请号：US09722010

    申请日：2000-11-27

    申请人： Kuen Yong Lee ,  David J. Mooney

    发明人： Kuen Yong Lee ,  David J. Mooney

    IPC分类号： A61K31734

    CPC分类号： C08L5/04 ,  A61L27/20 ,  C08B37/0084 ,  Y10S524/916

    摘要： A hydrogel composition and methods of preparing and using the same are disclosed. The hydrogel composition comprises an oxidized polysaccharide, and a cross-linker having at least two functional cross-linking groups. The cross-linker reversibly cross-links the polysaccharide and is provided in an amount to provide dangling cross-linkers. The method of preparing a hydrogel comprises the steps of providing an oxidized polysaccharide, and providing a cross-linker having at least two functional cross-linking groups. The cross-linker is mixed with the polysaccharide at a concentration of the cross-linker sufficient to form a hydrogel wherein the cross-linker reversibly cross-links the polysaccharide and has dangling cross-linkers. The hydrogels are useful, for example, for tissue engineering, cell transplantation and drug delivery applications.

    摘要翻译： 公开了一种水凝胶组合物及其制备和使用方法。 水凝胶组合物包含氧化多糖和具有至少两个功能性交联基团的交联剂。 交联剂可逆地交联多糖并提供一定量的悬浮交联剂。 制备水凝胶的方法包括提供氧化多糖的步骤，提供具有至少两个功能性交联基团的交联剂。 将交联剂与交联剂的浓度与多糖混合，足以形成水凝胶，其中交联剂可逆地交联多糖并具有悬挂的交联剂。 水凝胶可用于例如组织工程，细胞移植和药物递送应用。

    Drug release from polymer matrices through mechanical stimulation
    2.
    发明授权
    Drug release from polymer matrices through mechanical stimulation 失效
    通过机械刺激从聚合物基质释放药物

    公开(公告)号：US06748954B2

    公开(公告)日：2004-06-15

    申请号：US09983320

    申请日：2001-10-24

    申请人： Kuen Yong Lee ,  David J. Mooney

    发明人： Kuen Yong Lee ,  David J. Mooney

    IPC分类号： A61B1900

    CPC分类号： A61K9/0024 ,  A61K9/205 ,  Y10S128/12

    摘要： A method for drug delivery and polymer matrix suited to the method are disclosed. The polymer matrix has reversibly bound thereto a drug or combination of drugs, and is capable of releasing the drug or combination of drugs in response to mechanical stimulation of the polymer matrix. According to the method of this invention, such a polymer matrix is delivered to an in vivo locus, for example the site of a wound, trauma, etc., and mechanical stimulation of said polymer matrix is effected in vivo, thereby releasing the drug or combination of drugs in the area of the in vivo locus.

    摘要翻译： 公开了适用于该方法的药物递送方法和聚合物基质。 聚合物基质可逆地结合药物或药物组合，并且能够响应于聚合物基质的机械刺激而释放药物或药物组合。 根据本发明的方法，这种聚合物基质被递送到体内基因座，例如伤口，创伤等位点，并且所述聚合物基质的机械刺激在体内进行，从而释放药物或 药物在体内基因组区域的组合。

    Cold drink vending mechanism
    6.
    发明授权
    Cold drink vending mechanism 失效
    冷饮自动售货机制

    公开(公告)号：US5335818A

    公开(公告)日：1994-08-09

    申请号：US71641

    申请日：1993-06-03

    申请人： Algert J. Maldanis ,  Robert I. Courts ,  Dennis Dutkevitch ,  David J. Mooney

    发明人： Algert J. Maldanis ,  Robert I. Courts ,  Dennis Dutkevitch ,  David J. Mooney

    IPC分类号： G07F11/24 ,  G07F11/34 ,  G07F13/06 ,  G07T11/00 ,  B65G59/00

    CPC分类号： G07F11/34 ,  G07F11/24 ,  G07F13/065

    摘要： A vending mechanism for a cylindrical article dispenser of a type having a column of stacked cylindrical articles moved along a dispensing pathway by a force, such as by the force of gravity, is disclosed, which has an escapement mechanism which is attachable in operative alignment with a vending pathway of a column of stacked cylindrical articles. An upstream arm is pivotably attached in the escapement mechanism, having a first position blocking a portion of the vending pathway and having a second position retracted from the vending pathway to allow cylindrical articles to move past the upstream arm. A downstream arm is pivotably attached in the escapement mechanism, having a first position blocking a portion of the vending pathway and having a second position retracted from the vending pathway to allow cylindrical articles to move past the downstream arm. A first rotary cam is rotatably attached in the escapement mechanism and has a profile shape for moving the upstream arm between its first and second positions. A second rotary cam is coaxially rotatable with the first cam and has a profile shape for moving the downstream arm between its second position and its first position. The first and second rotatable cams have their profile shapes offset with respect to each other so that the upstream arm is moved into its blocking position only when the downstream arm is also in its blocking position, and so that the downstream arm is moved into or out of its blocking position only when the upstream arm is in its blocking position, such that co-rotation of the cams does not act to raise either the upstream or the downstream arm against the force which causes the column to move along the dispensing pathway.

    摘要翻译： 公开了一种用于圆柱形物品分配器的销售机构，其具有通过诸如通过重力的力沿着分配路径移动的堆叠的圆柱形物品的列的类型的销售机构，其具有擒纵机构，其可附接到与 一列堆叠的圆柱形物品的自动售货路径。 上游臂可枢转地附接在擒纵机构中，具有阻挡销售路径的一部分的第一位置，并且具有从自动销售路径缩回的第二位置，以允许圆柱形物品移动经过上游臂。 下游臂可枢转地附接在擒纵机构中，具有阻挡自动售货路径的一部分的第一位置，并且具有从自动售货路径缩回的第二位置，以允许圆柱形物品移动经过下游臂。 第一旋转凸轮可旋转地安装在擒纵机构中，并且具有用于在其第一和第二位置之间移动上游臂的轮廓形状。 第二旋转凸轮与第一凸轮同轴旋转，并且具有用于在其第二位置和其第一位置之间移动下游臂的轮廓形状。 第一和第二可旋转凸轮具有相对于彼此偏移的轮廓形状，使得仅当下游臂也处于其阻挡位置时，上游臂移动到其阻挡位置，并且使得下游臂被移入或移出 其阻塞位置仅在上游臂处于其阻挡位置时，使得凸轮的共同旋转不起作用以使上游臂或下游臂抵抗导致柱沿着分配路径移动的力。