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公开(公告)号：US09827332B2
公开(公告)日：2017-11-28
申请号：US14940512
申请日：2015-11-13
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Jeff Lynn Ellsworth , Kenechi Ejebe , Justin Guild , Matthias John , Paul Hatala , Atanu Roy , Jason P. Schrum , Susan Whoriskey , Kristy M. Wood
IPC: C12N15/85 , A61K47/48 , A61K48/00 , A61K31/7115 , A61K9/127 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , C07K14/47 , A61K38/17 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/87 , C12P13/04 , C12P21/00 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/525 , C07K14/56 , A61K9/14 , A61K31/7088 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20150315541A1
公开(公告)日：2015-11-05
申请号：US14651305
申请日：2013-12-12
Applicant: MODERNA THERAPEUTICS, INC.
Inventor： Stephane Bancel , Antonin de Fougerolles , Susan Whoriskey , Tirtha Chakraborty , Eric Yi-Chun Huang
IPC: C12N5/071 , C12N9/02 , C07K14/535 , C12P21/00
CPC classification number: C12N5/0602 , C07K14/535 , C12N9/0069 , C12N15/67 , C12N2500/40 , C12P21/00 , C12Y113/12
Abstract: The present invention relates to compositions, methods and kits using cell phenotype altering polynucleotides, cell phenotype altering primary transcripts and cell phenotype altering mmRNA molecules.
Abstract translation: 本发明涉及使用细胞表型改变多核苷酸的组合物，方法和试剂盒，改变初级转录物的细胞表型和改变mmRNA分子的细胞表型。
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公开(公告)号：US20150246139A1
公开(公告)日：2015-09-03
申请号：US14694357
申请日：2015-04-23
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: A61K48/00 , A61K38/48 , A61K38/18 , A61K38/19 , A61K39/395
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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公开(公告)号：US20150211039A1
公开(公告)日：2015-07-30
申请号：US14421291
申请日：2013-08-13
Applicant: Moderna Therapeutics, Inc.
Inventor： Yuxun Wang , Divakar Ramakrishnan , Antonin de Fougerolles , Susan Whoriskey
CPC classification number: C12P19/34 , C12N9/1241 , C12N9/1247 , C12N9/1252 , C12Y207/07006 , C12Y207/07007 , C12Y207/0705
Abstract: The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及用于与多核苷酸，初级转录物和mmRNA分子一起使用的酶的设计，进化，制备和/或制备的组合物和方法。
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5.发明申请MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS 有权用于生产CYPOPLASMIC和CYTOSKELETET蛋白质的改性多核苷酸公开(公告)号：US20150086614A1
公开(公告)日：2015-03-26
申请号：US14390098
申请日：2013-03-09
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: C07K14/535 , C07K14/505 , C07K14/475 , A61K47/34
CPC classification number: C07K14/535 , A61K47/34 , A61K48/005 , C07K14/475 , C07K14/505 , C12N15/67 , C12N15/85 , C12N2840/85
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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Patent Agency Ranking
6.发明申请MODIFIED POLYNUCLEOTIDES FOR TREATING CARBOXYPEPTIDASE N, POLYPEPTIDE 1 PROTEIN DEFICIENCY 审中-公开用于治疗羧基肽N，多肽1蛋白质缺陷的改性多核苷酸公开(公告)号：US20140200264A1
公开(公告)日：2014-07-17
申请号：US14171242
申请日：2014-02-03
Applicant: MODERNA THERAPEUTICS, INC.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey
IPC: C12N15/52
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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7.发明申请MODIFIED POLYNUCLEOTIDES ENCODING V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG 审中-公开编码V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG的修饰多核苷酸公开(公告)号：US20140193482A1
公开(公告)日：2014-07-10
申请号：US14104585
申请日：2013-12-12
Applicant: MODERNA THERAPEUTICS, INC.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss
IPC: C07K14/005
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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8.发明授权Modified polynucleotides for the production of oncology-related proteins and peptides 有权用于产生肿瘤学相关蛋白和肽的修饰多核苷酸公开(公告)号：US09587003B2
公开(公告)日：2017-03-07
申请号：US15015684
申请日：2016-02-04
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: C07K14/535 , C07K14/505
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
Abstract translation: 本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。
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9.发明授权Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins 有权用于产生细胞质和细胞骨架蛋白的修饰多核苷酸公开(公告)号：US09572897B2
公开(公告)日：2017-02-21
申请号：US15042173
申请日：2016-02-12
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: A61K48/00 , A61K31/7115 , A61K9/127 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , C07K14/47 , A61K38/17 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , A61K47/48 , C07K14/525 , C07K14/56 , A61K9/14 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/0019 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/48046 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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公开(公告)号：US09504734B2
公开(公告)日：2016-11-29
申请号：US14975141
申请日：2015-12-18
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild , Ron Weiss
IPC: C12N15/85 , A61K38/48 , A61K48/00 , C12N15/88 , A61K9/127 , A61K9/50 , A61K31/7088 , A61K47/48 , C07K19/00 , A61K38/18 , A61K38/19 , C07K14/47 , A61K9/00
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Abstract translation: 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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