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公开(公告)号：US20050004041A1
公开(公告)日：2005-01-06
申请号：US10496200
申请日：2002-11-21
申请人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
发明人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
CPC分类号： C07K14/4732 , A61K38/00 , C07K5/081
摘要： A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs.
摘要翻译： 用酪蛋白水解化学合成获得的肽Met-Lys-Pro作为血管紧张素转换酶抑制剂或降血压药物的有效成分。
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公开(公告)号：US07022676B2
公开(公告)日：2006-04-04
申请号：US10496200
申请日：2002-11-21
申请人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
发明人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
IPC分类号： A61K38/00
CPC分类号： C07K14/4732 , A61K38/00 , C07K5/081
摘要： A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs.
摘要翻译： 用酪蛋白水解化学合成获得的肽Met-Lys-Pro作为血管紧张素转换酶抑制剂或降血压药物的有效成分。
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公开(公告)号：US06395508B1
公开(公告)日：2002-05-28
申请号：US09316957
申请日：1999-05-24
申请人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
发明人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
IPC分类号： A23C2102
CPC分类号： A61K38/018 , A23J3/08 , A23J3/343 , A23L33/18 , A61K38/01 , Y10S530/833
摘要： A method for producing a peptide mixture from a starting protein by (1) adding at least one protease to an aqueous solution of at least one starting protein to hydrolyse the starting protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the starting protein, (3) calculating the amount of the free amino acid with respect to the total amount of amino acid contained in the starting protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the starting protein falls within a predetermined range. The inventive method provides a starting protein hydrolysate of uniform and consistent quality.
摘要翻译： （1）在至少一种起始蛋白质的水溶液中加入至少一种蛋白酶以水解起始蛋白质的方法，从起始蛋白质制备肽混合物的方法，（2）测量游离氨基酸的量 在起始蛋白水解期间产生的赖氨酸，苯丙氨酸，亮氨酸和精氨酸组成的组，（3）计算游离氨基酸相对于起始蛋白质中所含氨基酸总量的量，以及（4）终止 当游离氨基酸的计算量相对于起始蛋白质中含有的氨基酸总量的计算量落在预定范围内时，水解。 本发明的方法提供均匀且一致质量的起始蛋白质水解产物。
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公开(公告)号：US5952193A
公开(公告)日：1999-09-14
申请号：US817095
申请日：1997-04-14
申请人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
发明人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
CPC分类号： A61K38/018 , A23J3/08 , A23J3/343 , A23L33/18 , A61K38/01 , Y10S530/833
摘要： A method for producing a peptide mixture from whey protein by (1) adding at least one protease to an aqueous solution of at least one whey protein to hydrolyze the whey protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the whey protein, (3) calculating the amount of the free amino acid with respect to the total amount of the amino acid contained in the whey protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the whey protein falls within a predetermined range. The inventive method provides a whey protein hydrolysate of consistent quality.
摘要翻译： PCT No.PCT / JP95 / 02109 Sec。 371日期1997年04月14日 102（e）1997年4月14日PCT 1995年10月13日PCT PCT。 公开号WO96 / 11584 日期：1996年04月25日（一）通过（1）向至少一种乳清蛋白的水溶液中加入至少一种蛋白酶以水解乳清蛋白，从乳清蛋白制备肽混合物的方法，（2）测量游离氨基 选自在乳清蛋白水解期间产生的赖氨酸，苯丙氨酸，亮氨酸和精氨酸的酸，（3）计算游离氨基酸相对于乳清蛋白中所含氨基酸总量的量， 和（4）当游离氨基酸的计算量相对于乳清蛋白中所含氨基酸总量的计算量落在预定范围内时，终止水解。 本发明的方法提供了质量一致的乳清蛋白水解产物。
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公开(公告)号：US20070031506A1
公开(公告)日：2007-02-08
申请号：US11580173
申请日：2006-10-12
申请人： Hirotoshi Hayasawa , Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Tetsuya Kuhara , Hiroshi Ochi
发明人： Hirotoshi Hayasawa , Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Tetsuya Kuhara , Hiroshi Ochi
CPC分类号： A61K38/018
摘要： Whey protein is hydrolyzed with hydrolase so that a rate of hydrolysis is preferably 20 to 30%. A fraction, which has molecular weights above 10,000 daltons, is removed from a resultant hydrolysate by means of an ultrafiltration method to obtain a whey protein hydrolysate which is used as an active ingredient of an interleukin-18 inducer.
摘要翻译： 乳清蛋白用水解酶水解，水解速率优选为20〜30％。 通过超滤方法从所得水解产物中除去分子量高于10,000道尔顿的级分，得到用作白细胞介素-18诱导剂活性成分的乳清蛋白水解产物。
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6.发明授权
公开(公告)号：US5744179A
公开(公告)日：1998-04-28
申请号：US428129
申请日：1995-09-06
申请人： Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Yasushi Kawaguchi , Yoko Nagasako , Hiroshi Ochi
发明人： Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Yasushi Kawaguchi , Yoko Nagasako , Hiroshi Ochi
CPC分类号： C12Y304/00 , A23J1/205 , A23J3/343 , A23V2002/00
摘要： A whey protein having a phosphorus content reduced to below 0.15 mg per gram of protein, a manufacturing method thereof, a low-phosphorus hydrolysate highly purified having a low phosphorus content. The method comprises the steps of adjusting pH of the solution containing the whey protein to below 4, and contacting the solution with a cation exchange resin, sequentially contacting the solution with an anion exchange resin, thereby reducing the phosphorus content to below 0.15 mg per gram of protein, and the highly purified low-phosphorus whey protein hydrolysate of the present invention is available by hydrolyzing the above-mentioned low-phosphorus whey protein with proteases.
摘要翻译： PCT No.PCT / JP93 / 01729 Sec。 371日期：1995年9月6日 102（e）日期1995年9月6日PCT提交1993年11月26日PCT公布。 公开号WO94 / 12053 日期：1995年6月9日具有磷含量降低至低于0.15mg /克蛋白质的乳清蛋白，其制造方法，具有低磷含量的高度纯化的低磷水解产物。 该方法包括以下步骤：将含有乳清蛋白的溶液的pH调节至4以下，并使该溶液与阳离子交换树脂接触，依次使该溶液与阴离子交换树脂接触，从而将磷含量降低至低于0.15mg /克 的蛋白质，通过用蛋白酶水解上述低磷乳清蛋白，可获得本发明的高纯度低磷乳清蛋白水解产物。
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7.发明授权Protein hydrolyzates, process for producing the same and drinks and foods containing the protein hydrolyzates 失效蛋白质水解物，其制备方法以及含有蛋白质水解产物的饮料和食品公开(公告)号：US06908633B2
公开(公告)日：2005-06-21
申请号：US10148274
申请日：2001-03-12
申请人： Hirotoshi Hayasawa , Yoshitaka Tamura , Hiroshi Miyakawa , Toshikazu Shichino , Yasushi Kawaguchi , Hirokatsu Kanehara
发明人： Hirotoshi Hayasawa , Yoshitaka Tamura , Hiroshi Miyakawa , Toshikazu Shichino , Yasushi Kawaguchi , Hirokatsu Kanehara
IPC分类号： A23C9/152 , A23C11/04 , A23J3/30 , A23J3/34 , A23L1/305 , C07K1/12 , C07K1/20 , A23C9/12 , A23J1/00
CPC分类号： C07K1/20 , A23C9/1526 , A23C11/04 , A23J3/30 , A23J3/343 , A23J3/344 , A23L33/18 , A23L33/19 , A23V2002/00 , C07K1/12 , A23V2300/30
摘要： A protein hydrolysate comprising at least two types of peptides, characterized in that the rate of hydrolysis of protein is from 30 to 45%, the number average molecular weight is 300 or less, and the ratio of a weight average molecular weight to the number average molecular weight is greater than 1 and 2 or less, has excellent emulsifiability, and antigenicity thereof is low enough to be used for people who has predisposition to allergic diseases. This protein hydrolysate is obtained by hydrolysis of a protein starting material to a rate of hydrolysis in the range of 30 to 45%, and then bringing it into contact simultaneously or separately with two types of porous synthetic adsorbent respectively having an average pore radius of 2 to 8 nm and an average pore radius of 20 to 30 nm, the total surface area of the two porous synthetic adsorbents being in a range of 300 to 3000 m2 per 1 g (protein equivalent) of the obtained protein hydrolysate, and recovering the non-adsorbed component.
摘要翻译： 一种蛋白质水解物，其包含至少两种类型的肽，其特征在于蛋白质的水解速率为30〜45％，数均分子量为300以下，重均分子量与数均分子量的比例 分子量大于1和2以下，具有优异的乳化性，其抗原性低到足以用于具有过敏性疾病倾向的人。 该蛋白质水解物是通过将蛋白原料水解至30〜45％范围内的水解速率而获得的，然后使其与平均孔半径为2的两种类型的多孔合成吸附剂同时或分开地接触 至8nm，平均孔半径为20至30nm，两个多孔合成吸附剂的总表面积在每1000克（蛋白质当量）的300至3000微米2范围内 得到的蛋白质水解物，回收未吸附成分。
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8.发明授权Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效乳铁蛋白水解物用作抗菌剂和酪氨酸酶抑制剂
公开(公告)号：US5389611A
公开(公告)日：1995-02-14
申请号：US803955
申请日：1991-12-09
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02 , C07K3/10 , C07K1/12
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
摘要翻译： 乳铁蛋白水解物，通过甲酸滴定测定的分解率为6％-20％，用作抗菌剂，并且具有比未水解的乳铁蛋白显着更强的活性; 和通过甲酸滴定测定的分解率为4-50％的乳铁蛋白水解物，用作酪氨酸酶抑制剂，可通过用酸或酶水解的常规方法获得，并且对加热稳定。
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9.发明授权Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效用作抗菌剂和作为酪氨酸酶抑制剂的LACTOFERRIN水解产物
公开(公告)号：US5214028A
公开(公告)日：1993-05-25
申请号：US634763
申请日：1990-12-27
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
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10.发明授权Method for heat treatment of lactoferrin without losing physiological activities thereof 失效乳铁蛋白的热处理方法，而不会失去其生理活性
公开(公告)号：US5340924A
公开(公告)日：1994-08-23
申请号：US860224
申请日：1992-03-27
申请人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
发明人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
CPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , Y10S530/832
摘要： A method for treatment of a matter which contains moisturized or liquified lactoferrin which has been isolated from mammalian milk, processed mammalian milk and by-products in mammalian milk-processing, without losing the physiological activities of lactoferrin, which comprises adjusting pH of said moisturized or liquefied lactoferrin contained in said matter within an acidic range between 2.0 and 6.0 both inclusive by adding acid or aqueous solution of acid when the pH of said moisturized or liquefied lactoferrin is out of said pH range, and heating said matter in the range from 60.degree. C. to 130.degree. C. for a span of time which may assure 60% or more of undenaturization rate of lactoferrin.
摘要翻译： 一种处理含有保湿或液化的乳铁蛋白的物质的方法，其已从哺乳动物乳，加工的哺乳动物乳和哺乳动物乳加工中的副产物中分离出来，而不损失乳铁蛋白的生理活性，其包括调节所述保湿或 当所述保湿或液化的乳铁蛋白的pH在所述pH范围之外时，通过加入酸或酸的水溶液，在所述物质中含有的液化乳铁蛋白在2.0至6.0之间的酸性范围内，并且将所述物质加热到60℃ 在130℃下，可以确保乳铁蛋白的未饱和化率达到60％以上。
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