VACCINE
    7.
    发明申请
    VACCINE 审中-公开
    疫苗

    公开(公告)号:US20090191234A1

    公开(公告)日:2009-07-30

    申请号:US12343145

    申请日:2008-12-23

    摘要: This invention relates to three newly-identified, distinct groups of antigenic peptides [LB1(f) peptides] from the same region of the P5-like fimbrin protein discovered using sequence data from the fimbrin protein of many Haemophilus influenzae strains. The invention additionally provides chimeric polypeptides that carry one or more representatives of such peptides from different groups and which induce an immunogenic response in animals to Haemophilus influenzae. The peptides and polypeptides of the invention will be useful in vaccine compositions which provide protection against a wide range of H. influenzae strains.

    摘要翻译: 本发明涉及使用来自许多流感嗜血杆菌菌株的fimbrin蛋白的序列数据发现的来自P5样fimbrin蛋白的相同区域的三种新鉴定的不同组的抗原肽[LB1(f)肽]。 本发明另外提供了携带来自不同群体的这种肽的一种或多种代表并且在动物中对流感嗜血杆菌诱导免疫原性应答的嵌合多肽。 本发明的肽和多肽可用于提供针对广泛的流感嗜血杆菌菌株的保护的疫苗组合物中。

    Novel method for preventing or treating M tuberculosis infection
    10.
    发明申请
    Novel method for preventing or treating M tuberculosis infection 有权
    用于预防或治疗结核分枝杆菌感染的新方法

    公开(公告)号:US20090123491A1

    公开(公告)日:2009-05-14

    申请号:US11912730

    申请日:2006-04-27

    摘要: The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.

    摘要翻译: 本发明涉及通过施用包含编码Mtb72f融合蛋白或Mtb72f融合蛋白或其免疫原性片段的核酸的药物组合物,例如与佐剂一起施用来防止活性和潜伏性结核分枝杆菌感染的再活化的方法 。 Mtb72f核酸或融合蛋白可以与一种或多种对结核分枝杆菌感染有效的化学治疗剂一起施用。 所述方法还提供了缩短化疗方案针对结核分枝杆菌感染的时间过程。