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    Attenuated herpesvirus, herpesvirus which include foreign DNA encoding an amino acid sequence and vaccines containing same
    1.
    发明授权
    Attenuated herpesvirus, herpesvirus which include foreign DNA encoding an amino acid sequence and vaccines containing same 失效
    减毒疱疹病毒，疱疹病毒，其包括编码氨基酸序列的外源DNA和含有其的疫苗

    公开(公告)号：US5834305A

    公开(公告)日：1998-11-10

    申请号：US334428

    申请日：1994-11-04

    申请人： Mark D. Cochran ,  William P. MacConnell ,  Richard D. MacDonald ,  David E. Junker

    发明人： Mark D. Cochran ,  William P. MacConnell ,  Richard D. MacDonald ,  David E. Junker

    IPC分类号： C12N15/86

    CPC分类号： C12N15/86

    摘要： The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence. Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpes-virus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted. Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.

    摘要翻译： 本发明提供了一种杂合非疱疹病毒，其包含DNA，其包含杂合体病毒复制所必需的序列，非疱疹病毒，其至少一部分以天然存在的非疱疹病毒的复制必需的序列存在，并且至少 一个外来DNA序列。 还提供了一种减毒的非疱疹病毒，其包含DNA，其包括对于减毒的非疱疹病毒的病毒复制所必需的序列，其至少一部分以天然存在的非疱疹病毒的复制必需的序列存在， 其中至少一部分重复序列已被删除。 还提供了包含本发明病毒的疫苗和针对各种疾病免疫动物的方法。

    Nucleic acids encoding neutralizing GDF8 epitope-based peptides and fusion proteins
    7.
    发明授权
    Nucleic acids encoding neutralizing GDF8 epitope-based peptides and fusion proteins 失效
    编码中和GDF8表位的肽和融合蛋白的核酸

    公开(公告)号：US07585648B2

    公开(公告)日：2009-09-08

    申请号：US12061012

    申请日：2008-04-02

    申请人： David E. Junker ,  Mark D. Cochran

    发明人： David E. Junker ,  Mark D. Cochran

    IPC分类号： C12N15/11 ,  C12N15/62 ,  C12N15/63 ,  C12N15/64 ,  C12N1/21 ,  C12N5/10

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K39/00

    摘要： The invention provides new, specific nucleic acids encoding antigenic peptides from the protein GDF8. The invention also provides nucleic acids encoding fusion proteins comprising the new peptides, immunogens and vaccines based on the nucleic acids encoding new peptides and/or fusion proteins, antibodies that specifically bind to the new peptides of GDF8, and methods of treating animals in order to modulate the activity of GDF8, employing vaccines or antibodies according to the invention.

    摘要翻译： 本发明提供了编码来自蛋白GDF8的抗原肽的新的特异性核酸。 本发明还提供编码融合蛋白的核酸，其包含基于编码新肽和/或融合蛋白的核酸的新肽，免疫原和疫苗，特异性结合GDF8的新肽的抗体，以及治疗动物的方法，以便 调节GDF8的活性，使用根据本发明的疫苗或抗体。