公开(公告)号：US06856712B2

公开(公告)日：2005-02-15

申请号：US09994377

申请日：2001-11-26

申请人： Mark E. Fauver ,  Eric J. Seibel ,  Chris M. Brown ,  Per G. Reinhall ,  Quinn Y. J. Smithwick

发明人： Mark E. Fauver ,  Eric J. Seibel ,  Chris M. Brown ,  Per G. Reinhall ,  Quinn Y. J. Smithwick

IPC分类号： G02B6/26 ,  G02B6/32 ,  G02B6/35 ,  G02B26/10 ,  G02B6/00

CPC分类号： G02B6/241 ,  G02B6/245 ,  G02B6/25 ,  G02B6/262 ,  G02B6/32 ,  G02B6/3502 ,  G02B6/3586 ,  G02B26/10

摘要： Small, rugged scanners micro-fabricated from commercial optical fibers to form waveguides or other structures. The scanning waveguide has a distal portion on which is formed a non-linear taper with a diameter that decreases toward a distal end. Optionally, a hinge portion having a reduced diameter can be formed in the distal portion, improving the scanning properties of the waveguide. A micro-lens can be integrally formed at the distal tip of the waveguide with either a droplet of an optical adhesive, or by using an energy beam to melt the material of the waveguide to form a droplet. The droplet is shaped with an externally applied force. When mechanically driven in vibratory resonance, the tip of the optical waveguides moves in linear or two-dimensional scan patterns of relatively high amplitude and frequency, and large field of view. The scanner can be used either for image acquisition or image display.

摘要翻译： 小型，坚固的扫描仪，由商用光纤微型制造，形成波导或其他结构。 扫描波导具有远端部分，其上形成具有朝向远端减小的直径的非线性锥形。 可选地，可以在远端部分形成具有减小的直径的铰链部分，从而改善波导的扫描特性。 微透镜可以在波导的远端与光学粘合剂的液滴一体地形成，或者通过使用能量束来熔化波导的材料以形成液滴。 液滴以外部施加的力成形。 当以振动共振机械驱动时，光波导的尖端以相对高的振幅和频率以及较大的视场的线性或二维扫描图案移动。 扫描仪可用于图像采集或图像显示。

公开(公告)号：US07555333B2

公开(公告)日：2009-06-30

申请号：US10655482

申请日：2003-09-04

申请人： Wei-Chi Wang ,  Eric J. Seibel ,  Per G. Reinhall ,  Mark E. Fauver ,  Chris M. Brown

发明人： Wei-Chi Wang ,  Eric J. Seibel ,  Per G. Reinhall ,  Mark E. Fauver ,  Chris M. Brown

IPC分类号： A61B6/00

CPC分类号： A61B5/0062 ,  A61B1/00048 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/00183 ,  A61B1/00193 ,  A61B1/0051 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1076 ,  A61N5/0601 ,  A61N5/062 ,  G02B6/262 ,  G02B6/32 ,  G02B6/3502 ,  G02B6/3566 ,  G02B6/357 ,  G02B6/3572 ,  G02B6/3578 ,  G02B23/2484 ,  G02B26/0875 ,  G02B26/10 ,  G02B26/101

摘要： An apparatus and method for providing image acquisition and/or image display in a limited region of interest (ROI). The apparatus comprises a micro electro-mechanical system (MEMS), preferably integrating a light source, a cantilever, a lens, an actuator, a light detector, and a position sensor. The light source provides light for illuminating the ROI, displaying an image, providing a therapy, and/or performing other functions. The cantilever comprises a resin waveguide with a fixed end attached to a substrate that supports many or all other components. A free end of the cantilever is released from the substrate during fabrication and includes the lens. The actuator scans the free end in orthogonal directions to illuminate the ROI or display an image. The position sensors detect the position of the free end for control. The light detector receives light backscattered from the ROI separate from, or at the fixed end the cantilever.

摘要翻译： 一种用于在有限的感兴趣区域（ROI）中提供图像获取和/或图像显示的装置和方法。 该装置包括微机电系统（MEMS），优选地集成光源，悬臂，透镜，致动器，光检测器和位置传感器。 光源提供用于照亮ROI，显示图像，提供治疗和/或执行其他功能的光。 悬臂包括具有固定端连接到支撑多个或所有其它部件的基板的树脂波导。 在制造过程中，悬臂的自由端从基板释放并且包括透镜。 致动器沿正交方向扫描自由端以照亮ROI或显示图像。 位置传感器检测自由端的位置进行控制。 光检测器接收来自ROI的反向散射光，或者在固定端处悬臂。

公开(公告)号：US20090235396A1

公开(公告)日：2009-09-17

申请号：US12434129

申请日：2009-05-01

申请人： Wei-Chih Wang ,  Eric J. Seibel ,  Per G. Reinhall ,  Mark E. Fauver ,  Chris M. Brown

发明人： Wei-Chih Wang ,  Eric J. Seibel ,  Per G. Reinhall ,  Mark E. Fauver ,  Chris M. Brown

IPC分类号： G01N13/10

CPC分类号： A61B5/0062 ,  A61B1/00048 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/00183 ,  A61B1/00193 ,  A61B1/0051 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1076 ,  A61N5/0601 ,  A61N5/062 ,  G02B6/262 ,  G02B6/32 ,  G02B6/3502 ,  G02B6/3566 ,  G02B6/357 ,  G02B6/3572 ,  G02B6/3578 ,  G02B23/2484 ,  G02B26/0875 ,  G02B26/10 ,  G02B26/101

摘要： An apparatus and method for providing image acquisition and/or image display in a limited region of interest (ROI). The apparatus comprises a micro-electro-mechanical system (MEMS), preferably integrating a light source, a cantilever, a lens, an actuator, a light detector, and a position sensor. The light source provides light for illuminating the ROI, displaying an image, providing a therapy, and/or performing other functions. The cantilever comprises a resin waveguide with a fixed end attached to a substrate that supports many or all other components. A free end of the cantilever is released from the substrate during fabrication and includes the lens. The actuator scans the free end in orthogonal directions to illuminate the ROI or display an image. The position sensors detect the position of the free end for control. The light detector receives light backscattered from the ROI separate from, or at the fixed end of the cantilever.

摘要翻译： 一种用于在有限的感兴趣区域（ROI）中提供图像获取和/或图像显示的装置和方法。 该装置包括微机电系统（MEMS），优选地集成光源，悬臂，透镜，致动器，光检测器和位置传感器。 光源提供用于照亮ROI，显示图像，提供治疗和/或执行其他功能的光。 悬臂包括具有固定端连接到支撑多个或所有其它部件的基板的树脂波导。 在制造过程中，悬臂的自由端从基板释放并且包括透镜。 致动器沿正交方向扫描自由端以照亮ROI或显示图像。 位置传感器检测自由端的位置进行控制。 光检测器从与悬臂的固定端分离或在悬臂的固定端接收来自ROI的反向散射光。

公开(公告)号：US20120196320A1

公开(公告)日：2012-08-02

申请号：US13091088

申请日：2011-04-20

申请人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall ,  Duane W. Storti

发明人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall ,  Duane W. Storti

IPC分类号： G01N1/30 ,  H04N13/02 ,  G01N1/31 ,  H04N7/18

CPC分类号： G01N1/30

摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.

摘要翻译： 声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。 一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。 计算机捕获图像并生成3D合成图像。 还要求的是用于制备用于光学显微镜的样品的系统和方法。 一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。

公开(公告)号：US08867803B2

公开(公告)日：2014-10-21

申请号：US13091088

申请日：2011-04-20

申请人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall

发明人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall

IPC分类号： G06K9/00

CPC分类号： G01N1/30

摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.

摘要翻译： 声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。 一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。 计算机捕获图像并生成3D合成图像。 还要求的是用于制备用于光学显微镜的样品的系统和方法。 一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。

公开(公告)号：US20080147000A1

公开(公告)日：2008-06-19

申请号：US11610084

申请日：2006-12-13

申请人： Eric J. Seibel ,  Per G. Reinhall

发明人： Eric J. Seibel ,  Per G. Reinhall

IPC分类号： A61M25/01

CPC分类号： A61M25/0158 ,  A61M25/0141 ,  A61M25/0155 ,  A61M2025/0058

摘要： A distal end of a flexible catheter can be selectively deflected in a desired direction by actuating one or more actuators that extend outwardly of an exterior surface of the catheter. Each actuator can be a balloon disposed within a non-extendible balloon or sheath. Inflation of one (or both) of the balloon and the non-extendible balloon with a pressurized fluid can deflect the distal tip of the catheter. Another actuator embodiment comprises a strip of a bimorph material that bends outwardly when actuated, e.g., by heat, applying a force against adjacent tissue to deflect the distal tip. Yet another embodiment includes a strip of material that shortens when heated and can be coupled to a balloon that is inflated outwardly to increase a radial moment arm of the force applied thereby, relative to a neutral axis of the catheter, to more readily deflect the distal tip.

摘要翻译： 柔性导管的远端可以通过致动一个或多个从导管的外表面向外延伸的致动器而在期望的方向上选择性地偏转。 每个致动器可以是设置在不可扩展的气球或护套内的球囊。 一个（或两个）球囊和不可延伸球囊与加压流体的充气可偏转导管的远端。 另一致动器实施例包括双压电晶片材料的条带，当致动例如通过加热时向外弯曲，向相邻组织施加力以偏转远侧末端。 另一个实施例包括材料条，其在加热时缩短并且可以联接到向外膨胀的球囊，以相对于导管的中性轴线增加由其施加的力的径向力矩臂，以更容易地偏转远端 小费。

公开(公告)号：US10557778B2

公开(公告)日：2020-02-11

申请号：US14453938

申请日：2014-08-07

申请人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall

发明人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall

IPC分类号： G01N1/30

摘要： An imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images is disclosed. One embodiment includes a light source and an imaging system having an adjustable focal position, which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also disclosed is a system and method for preparing a specimen for optical microscopy. One embodiment includes fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.

公开(公告)号：US20140342395A1

公开(公告)日：2014-11-20

申请号：US14453938

申请日：2014-08-07

申请人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall

发明人： Eric J. Seibel ,  Qin Miao ,  Ryan Lee Coe ,  Per G. Reinhall

IPC分类号： G01N1/30

CPC分类号： G01N1/30

摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.

摘要翻译： 声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。 一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。 计算机捕获图像并生成3D合成图像。 还要求的是用于制备用于光学显微镜的样品的系统和方法。 一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。

公开(公告)号：US07295724B2

公开(公告)日：2007-11-13

申请号：US11068938

申请日：2005-02-28

申请人： Wei-Chih Wang ,  Per G. Reinhall

发明人： Wei-Chih Wang ,  Per G. Reinhall

IPC分类号： G02B6/00

CPC分类号： A61B5/6892 ,  A61B5/1036 ,  A61B2562/0266 ,  G01D5/35303 ,  G01L1/246 ,  G02B6/12007 ,  G02B6/132 ,  G02B2006/12107 ,  G02B2006/12176

摘要： According to embodiments of the present invention, a distributed pressure and shear stress sensor includes a flexible substrate, such as PDMS, with a waveguide formed thereon. Along the waveguide path are several Bragg gratings. Each Bragg grating has a characteristic Bragg wavelength that shifts in response to an applied load due to elongation/compression of the grating. The wavelength shifts are monitored using a single input and a single output for the waveguide to determine the amount of applied pressure on the gratings. To measure shear stress, two flexible substrates with the waveguide and Bragg gratings are placed on top of each other such that the waveguides and gratings are perpendicular to each other. To fabricate the distributive pressure and shear sensor, a unique micro-molding technique is used wherein gratings are stamped into PDMS, for example.

摘要翻译： 根据本发明的实施例，分布式压力和剪切应力传感器包括柔性基板，例如PDMS，其上形成有波导。 沿着波导路径是几个布拉格光栅。 每个布拉格光栅具有由于光栅的伸长/压缩而响应于施加的负载而偏移的特征布拉格波长。 使用波导的单个输入和单个输出监测波长偏移，以确定光栅上施加的压力的量。 为了测量剪切应力，将具有波导和布拉格光栅的两个柔性基板放置在彼此的顶部上，使得波导和光栅彼此垂直。 为了制造分布式压力和剪切传感器，使用独特的微型成型技术，其中例如将光栅冲压成PDMS。

公开(公告)号：US09345424B2

公开(公告)日：2016-05-24

申请号：US13058523

申请日：2009-04-03

申请人： Wei-Chih Wang ,  David J. Nuckley ,  Per G. Reinhall ,  David Linders

发明人： Wei-Chih Wang ,  David J. Nuckley ,  Per G. Reinhall ,  David Linders

IPC分类号： A61B5/103 ,  A61B5/00 ,  A61B5/02

CPC分类号： A61B5/103 ,  A61B5/02 ,  A61B5/4528 ,  A61B5/6806 ,  A61B5/7207 ,  A61B5/7257 ,  A61B2562/0247 ,  A61B2562/0266 ,  A61B2562/043

摘要： A clinical sensing glove system to quantify force, shear, hardness, etc., measured in manual therapies is disclosed. A sensor is disposed in a clinical glove. The sensor undergoes micro-bending, macro-bending, evanescent coupling, a change in resonance, a change in polarization, a change in phase modulation, in response to pressure/force applied. The amount of micro-bending, macro-bending, evanescent coupling, change in resonance, change in polarization, and/or change in phase modulation is proportional to the intensity of the pressure/force. A clinician can quantitatively determine the amount of pressure, force, shear, hardness, rotation, etc., applied.

摘要翻译： 公开了用于量化在手动治疗中测量的力，剪切，硬度等的临床感测手套系统。 传感器设置在临床手套中。 响应于施加的压力/力，传感器经历微弯曲，宏弯曲，ev逝耦合，共振变化，极化的变化，相位调制的变化。 微弯曲，宏弯曲，ev逝耦合，谐振变化，极化变化和/或相位调制变化的量与压力/力的强度成比例。 临床医生可以定量测定施加的压力，力，剪切力，硬度，旋转等量。