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1.发明授权公开(公告)号：US06583154B1
公开(公告)日：2003-06-24
申请号：US09640263
申请日：2000-08-16
申请人： Mark Henry Norman , Clarence R. Hurt , Ning Chen , Christopher H. Fotsch , Nianhe Han , Tracy J. Jenkins , Longbin Liu , Ofir A. Moreno
发明人： Mark Henry Norman , Clarence R. Hurt , Ning Chen , Christopher H. Fotsch , Nianhe Han , Tracy J. Jenkins , Longbin Liu , Ofir A. Moreno
IPC分类号： A61K3144
CPC分类号： C07D491/04 , A61K31/437 , A61K31/519 , C07D471/04 , C07D487/04 , C07D495/04
摘要： There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.
摘要翻译： 提供了在调节进食行为，肥胖症，糖尿病，癌症（肿瘤），炎症性疾病，抑郁症，应激相关疾病，阿尔茨海默氏病和其他疾病状况中使用的化合物，组合物和方法。
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2.发明授权公开(公告)号：US06187777B1
公开(公告)日：2001-02-13
申请号：US09246775
申请日：1999-02-04
申请人： Mark Henry Norman , Clarence R. Hurt , Ning Chen , Christopher H. Fotsch , Nianhe Han , Tracy J. Jenkins , Longbin Liu , Ofir A. Moreno
发明人： Mark Henry Norman , Clarence R. Hurt , Ning Chen , Christopher H. Fotsch , Nianhe Han , Tracy J. Jenkins , Longbin Liu , Ofir A. Moreno
IPC分类号： A61K31519
CPC分类号： C07D491/04 , A61K31/437 , A61K31/519 , C07D471/04 , C07D487/04 , C07D495/04
摘要： There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.
摘要翻译： 提供了在调节进食行为，肥胖症，糖尿病，癌症（肿瘤），炎症性疾病，抑郁症，应激相关疾病，阿尔茨海默氏病和其他疾病状况中使用的化合物，组合物和方法。
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公开(公告)号：US20090264424A1
公开(公告)日：2009-10-22
申请号：US12492376
申请日：2009-06-26
申请人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： A61K31/536 , C07D265/36 , A61P29/00
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。
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公开(公告)号：US07579347B2
公开(公告)日：2009-08-25
申请号：US11100077
申请日：2005-04-05
申请人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , A61K31/4427 , A61K31/4523 , A61K31/47 , A61K31/497 , A61K31/5377 , A61P29/00 , A61P25/04
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。
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公开(公告)号：US07115607B2
公开(公告)日：2006-10-03
申请号：US10202823
申请日：2002-07-24
申请人： Christopher H. Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin H. Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael G. Kelly , Qingyian Liu , Mark H. Norman , Duncan M. Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu
发明人： Christopher H. Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin H. Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael G. Kelly , Qingyian Liu , Mark H. Norman , Duncan M. Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu
IPC分类号： A61K31/496 , C07D401/12 , C07D403/12
CPC分类号： C07D207/08 , A61K38/00 , C07D205/04 , C07D207/09 , C07D209/14 , C07D209/42 , C07D211/26 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/06 , C07D217/14 , C07D217/26 , C07D233/64 , C07D295/185 , C07D317/60 , C07D317/68 , C07D319/18 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07K5/06026 , C07K5/06139 , C07K5/06147 , C07K5/06191
摘要： Selected substituted piperazine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 式I的选择性取代哌嗪化合物对预防和治疗诸如肥胖症等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及黑皮质素受体活化的疾病和其它疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20120010256A1
公开(公告)日：2012-01-12
申请号：US13233699
申请日：2011-09-15
申请人： Martin HENRIKSSON , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric A. Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, JR. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
发明人： Martin HENRIKSSON , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric A. Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, JR. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
IPC分类号： A61K31/426 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/12 , A61P17/06 , A61P25/28 , A61P25/24 , A61P31/12 , A61P29/00 , A61P17/02 , C07D277/54 , A61P19/10
CPC分类号： C07D277/54 , C07D263/34 , C07D275/03 , C07D277/60 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/10
摘要： The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译： 本发明涉及具有式（I），（II），（III）或（IV）的化合物：其中R1，R2，R3，R4，R5，R6，R7，X和Z如本文所定义， 涉及包含该化合物的药物组合物，以及该化合物用于治疗与人类11-羟基类固醇脱氢酶1型酶相关的病症的用途和用于制备作用于人类11- 羟类固醇脱氢酶1型酶。
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公开(公告)号：US20090054460A1
公开(公告)日：2009-02-26
申请号：US12008696
申请日：2008-01-11
申请人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20090048224A1
公开(公告)日：2009-02-19
申请号：US12205616
申请日：2008-09-05
申请人： Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
发明人： Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
IPC分类号： A61K31/397 , A61K31/453 , C07D401/02 , C07D405/02 , A61K31/496 , A61K31/4545 , C07D407/02 , A61K31/4025 , A61K31/351 , A61P27/02 , A61P27/06 , A61P11/06 , A61P9/00 , A61P19/02 , A61P25/28 , A61K31/4375 , C07D471/04 , C07D205/04 , A61P3/10 , C07D311/02 , C07D413/02 , A61K31/5377 , A61K31/5415 , C07D279/02 , C07C311/01 , A61K31/18
CPC分类号： C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US07514566B2
公开(公告)日：2009-04-07
申请号：US11652728
申请日：2007-01-11
申请人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
发明人： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译： 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。
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公开(公告)号：US07425631B2
公开(公告)日：2008-09-16
申请号：US10823377
申请日：2004-04-12
申请人： Robert D. Groneberg , Benny C. Askew, Jr. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
发明人： Robert D. Groneberg , Benny C. Askew, Jr. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
IPC分类号： C07D215/04
CPC分类号： C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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